Yıl 2021, Cilt 8 , Sayı 1, Sayfalar 321 - 328 2021-02-28

Antimicrobial Activity Evaluation of Newly Synthesized N,N-Disubstituted Taurinamidobenzenesulfonamide Derivatives

Özlem AKGÜL [1] , Ayşegül ATEŞ [2] , Şafak ERMERTCAN [3]


Herein we synthesized 6 new N,N-disubstituted taurinamidobenzensulfonamide derivatives and characterized their structures by means of 1H and 13C NMR, HR-MS analysis. In addition, their in vitro antibacterial and antifungal activities were tested against two gram-positive, two gram-negative bacteria, and two fungal strains by using broth microdilution method. Compounds 1 (methoxy substitution) and 2 (methyl substitution) displayed the best antibacterial activity against Escherichia coli and Staphylococcus aureus, respectively. E. faecalis was affected by compounds 1, 2, 4, and 6, becoming the most susceptible pathogen compared to other tested bacterial and fungal strains. Interestingly, changing fluoro atom in compound 6 with the chloro atom, as in compound 5, deteriorated the antibacterial activity against all bacterial strains. As a result, these results provide us to investigate the relationship between structural changes and antibacterial/antifungal activity, which can be further used to develop more effective taurine derivatives.
Taurine, taurinamidobenzensulfonamide, antibacterial, antifungal, microdilution
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Birincil Dil en
Konular Kimya, Organik, Biyokimya ve Moleküler Biyoloji
Bölüm Makaleler
Yazarlar

Orcid: 0000-0002-0011-7888
Yazar: Özlem AKGÜL (Sorumlu Yazar)
Kurum: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University
Ülke: Turkey


Orcid: 0000-0001-6891-6662
Yazar: Ayşegül ATEŞ
Kurum: Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ege University
Ülke: Turkey


Orcid: 0000-0001-6686-6892
Yazar: Şafak ERMERTCAN
Kurum: Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ege University
Ülke: Turkey


Destekleyen Kurum The Scientific and Technological Research Council of Turkey [TUBITAK; Project number: SBAG- 117S516] and Ege University Scientific Research Projects Coordination Unit [Project number: 16-ECZ-012].
Proje Numarası SBAG- 117S516, 16-ECZ-012.
Tarihler

Başvuru Tarihi : 1 Aralık 2020
Kabul Tarihi : 12 Ocak 2021
Yayımlanma Tarihi : 28 Şubat 2021

Vancouver Akgül Ö , Ateş A , Ermertcan Ş . Antimicrobial Activity Evaluation of Newly Synthesized N,N-Disubstituted Taurinamidobenzenesulfonamide Derivatives. Journal of the Turkish Chemical Society Section A: Chemistry. 2021; 8(1): 321-328.