Spectroscopic and Photonic Properties of Dexamethasone used in the Treatment of COVID-19 Patients

Yıl 2023, , 132 - 137, 18.12.2023

Bayram Gündüz , Kenan Buldurun

https://doi.org/10.54565/jphcfum.1402365

Öz

Dexamethasone is a synthetic adrenal corticosteroid with potent anti-inflammatory properties. Dexamethasone (MK-125) is a position 9 fluorinated corticosteroid used to treat endocrine, rheumatic, collagen, dermatological, allergic, ophthalmic, gastrointestinal, respiratory, hematological, neoplastic, edematous, and other conditions. On June 16, 2020, a press release for the Randomized Evaluation of COVID-19 Treatment (RECOVERY) trial recommended the use of dexamethasone in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one-third in ventilated patients and one-fifth in patients requiring oxygen. Therefore, Dexamethasone is used in the treatment of COVID-19 patients in some countries. In this study, we researched the spectroscopic and photonic properties of Dexamethasone. We have extensively studied the absorption spectra at different concentrations and their response to light. This study shows the absorbance spectra of the Dexamethasone for various concentrations. On the other hand, we continue to work intensively on some herbal suggestions that can be considered equivalent to Dexamethasone.

Anahtar Kelimeler

Covid-19, Dexamethasone, absorbance, photonic properties, different concentrations

Kaynakça

• https://pubchem.ncbi.nlm.nih.gov/compound/Dexamethasone.
• Bunim, J.J., Black, R.L., Lutwak, L., Peterson, R.E. and Whedon, G.D. (1958), Studies on dexamethasone, a new synthetic steroid, in rheumatoid arthritis—a preliminary report. Arthritis & Rheumatism, 1: 313-331.
• The American Society of Health-System Pharmacists. Archived from the original on 31 August 2017. Retrieved 29 July 2015 (https://en.wikipedia.org/wiki/Dexamethasone#cite_note-AHFS2015-10).
• George, P. M., Wells, A. U. & Jenkins, R. G. Lancet Respir. Med. https://doi.org/10.1016/S2213-2600(20)30225-3 (2020).
• Lammers, T., Sofias, A.M., Van der Meel, R., Schiffelers, R., Storm, G., Tacke, F., Koschmieder, S., Brümmendorf, T.H., Kiessling, F., Metselaar, J. (2020). Dexamethasone nanomedicines for COVID-19. Nat. Nanotechnol. 15, 622–624. https://doi.org/10.1038/s41565-020-0752-z
• Ahmed, M.H., Hassan, A. (2020) Dexamethasone for the Treatment of Coronavirus Disease (COVID-19): a Review. SN Compr. Clin. Med. 2, 2637–2646. https://doi.org/10.1007/s42399-020-00610-8.
• Águas, R., Mahdi, A., Shretta, R., Horby, P., Landray, M., White L., Consortium, T. C.M. (2021). Potential health and economic impacts of dexamethasone treatment for patients with COVID-19. Nat Commun 12, 915. https://doi.org/10.1038/s41467-021-21134-2.
• Tomazini, B.M., Maia, I.S., Cavalcanti, A.B., et al. Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial. JAMA. 2020;324(13):1307–1316. doi:10.1001/jama.2020.17021.
• https://pubchem.ncbi.nlm.nih.gov/compound/Dexamethasone#section=2D-Structure
• https://www.hindawi.com/journals/jchem/2022/4912143/fig1/ https://pubchem.ncbi.nlm.nih.gov/compound/Dexamethasone#section=Crystal-Structures
• Partheniadis, I., Karakasidou, P., Vergkizi, S., & Nikolakakis, I. (2017). Spectroscopic examination and release of microencapsulated oregano essential oil. ADMET and DMPK, 5(4), 224–233.
• Gündüz, B. (2013). Effects of molarity and solvents on the optical properties of the solutions of tris [4-(5-dicyanomethylidenemethyl-2-thienyl) phenyl] amine (TDCV-TPA) and structural properties of its film. Opt. Mater., 36(2), 425-436. https://doi.org/10.1016/j.optmat.2013.10.005 J. Tauc, A. Menth, States in the gap, Journal of Non-Crystalline Solids, 8-10 (1972) 569-585.
• Buldurun, K., Gündüz, B., Turan, N., Çolak N. (2019). Synthesis, Characterization, Optical Transition and Dielectric Properties of the Schiff Base Ligand and Its Cobalt(II) and Palladium(II) Complexes. J. Electron. Mater. 48, 7131–7138. https://doi.org/10.1007/s11664-019-07525-8.
• Turan, N., Buldurun, K., Gündüz, B., Çolak, N. (2017). Synthesis and Structures of Fe(II), Zn(II) and Pd(II) Complexes with a Schiff Base Derived from Methyl 2-Amino-6-Methyl-4,5,6,7-Tetrahydrothieno[2,3-c] Pyridine-3-Carboxylate and Comparison of Their Optical Constants for Different Solvents and Molarities, J. Nanoelectron. Optoelectron., 12, 1028-1040. https://doi.org/10.1007/s12221-012-0415-2.
• Kurt, A., Gündüz, B., Koca, M. (2019). A detailed study on the optical properties of 3-benzoyl-7-hydroxy coumarin compound in different solvents and concentrations. Maced. J. Chem. Chem. Eng., 38(2), 227–236. https://doi.org/10.20450/mjcce.2019.140.
• Abeles F (1972) Optical properties of solids. North-Holland Publishing Company, London, Amsterdam.