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Myocardial dysfunction in malnourished children

Yıl 2010, Cilt: 2 Sayı: 2, 0 - , 22.05.2010

Öz

Background: Malnourished children suffer several alterations in body composition that could produce cardiac abnormalities. Measurement of cardiac troponin T (cTnT) in blood is considered one of the gold standers for detecting heart damage and not only used as an indicator of myocardial damage but also for prognostic information.
The aim of this study was to detect the frequency of myocardial damage as shown by echocardiography and cTnT level in malnourished children.
Patients and methods: The current study included 45 malnourished infants and young children (25 male and 20 female) with a mean age 11.24 ± 7.88 months, as well as 25 apparently healthy age and sex matched children (11 male and 13 female) with a mean age 10.78± 6.29 months as a control group. Complete blood picture, serum albumin, liver and kidney function tests, serum sodium, potassium and calcium level, cardiac troponin T and echocardiographic evaluation were done for cases and controls.
Results: The results of the present study revealed a significantly lower left ventricular (LV) mass in patients than the control group, and the left ventricular mass index (LVMI) was correlated positively with the body mass index (BMI). In patients with third degree marasmus (M III), kwashiorkor (KWO) marasmic-kwashiorkor (M-KWO) the LV systolic functions were significantly impaired in comparison to controls. cTnT levels were higher than the upper reference limits in 11 (24.44 %) of the studied children with PEM, all of them had severe degree of malnutrition, 6 (54.5%) of them had marasmus third degree, 2 (18%) of them had kwashiorkor (KWO) and 3 (27.7%) had marasmic-kwashiorkor (M-KWO). cTnT level was significantly higher in patients with anemia, sepsis, electrolyte deficiency and it correlated negatively to LVEF. Six (54.5%) of studied children with high cTnT levels died within 21 days of treatment compared to one (2.9%) of those with baseline levels.
Conclusion: LV mass are reduced in malnourished children in proportion to the decrease in body size. Children with M III, KWO and M-KWO not only have cardiac muscle wasting, but also have a significant decrease in LV systolic functions. Elevated cardiac troponin level in malnourished children has both diagnostic and prognostic significance for cardiomyocyte damage.

Yıl 2010, Cilt: 2 Sayı: 2, 0 - , 22.05.2010

Öz

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Ayrıntılar

Birincil Dil İngilizce
Bölüm Original Articles
Yazarlar

Nagla Abufaddan

Khalid El Sayh Bu kişi benim

Hamdy Shams Bu kişi benim

Hosni Badrawy Bu kişi benim

Yayımlanma Tarihi 22 Mayıs 2010
Yayımlandığı Sayı Yıl 2010 Cilt: 2 Sayı: 2

Kaynak Göster

APA Abufaddan, N., El Sayh, K., Shams, H., Badrawy, H. (2010). Myocardial dysfunction in malnourished children. Journal of Pediatric Sciences, 2(2). https://doi.org/10.17334/jps.26615
AMA Abufaddan N, El Sayh K, Shams H, Badrawy H. Myocardial dysfunction in malnourished children. Journal of Pediatric Sciences. Mayıs 2010;2(2). doi:10.17334/jps.26615
Chicago Abufaddan, Nagla, Khalid El Sayh, Hamdy Shams, ve Hosni Badrawy. “Myocardial Dysfunction in Malnourished Children”. Journal of Pediatric Sciences 2, sy. 2 (Mayıs 2010). https://doi.org/10.17334/jps.26615.
EndNote Abufaddan N, El Sayh K, Shams H, Badrawy H (01 Mayıs 2010) Myocardial dysfunction in malnourished children. Journal of Pediatric Sciences 2 2
IEEE N. Abufaddan, K. El Sayh, H. Shams, ve H. Badrawy, “Myocardial dysfunction in malnourished children”, Journal of Pediatric Sciences, c. 2, sy. 2, 2010, doi: 10.17334/jps.26615.
ISNAD Abufaddan, Nagla vd. “Myocardial Dysfunction in Malnourished Children”. Journal of Pediatric Sciences 2/2 (Mayıs 2010). https://doi.org/10.17334/jps.26615.
JAMA Abufaddan N, El Sayh K, Shams H, Badrawy H. Myocardial dysfunction in malnourished children. Journal of Pediatric Sciences. 2010;2. doi:10.17334/jps.26615.
MLA Abufaddan, Nagla vd. “Myocardial Dysfunction in Malnourished Children”. Journal of Pediatric Sciences, c. 2, sy. 2, 2010, doi:10.17334/jps.26615.
Vancouver Abufaddan N, El Sayh K, Shams H, Badrawy H. Myocardial dysfunction in malnourished children. Journal of Pediatric Sciences. 2010;2(2).