Probiotic use as capable preventive and therapeutic strategy in different diseases varying from allergic to autoimmune disease has recently been reported. Three interacting factors including an aberrant intestinal microbiota, a 'leaky' intestinal mucosal barrier, and altered intestinal immune responsiveness have been suggested to be able to create a ''perfect environment'' for autoimmune disease development. Regulation of intestinal microflora composition by probiotics offers the possibility to influence the development of mucosal/systemic immunity besides autoimmune diseases. Although there is a large amount of conflicting data on the preventive/therapeutic effects of probiotics in ADs; there is fairly promising evidence to recommend as well. Thus, probiotic use cannot be generally recommended for primary prevention and therapy of ADs for now.
Birincil Dil | İngilizce |
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Bölüm | Reviews |
Yazarlar | |
Yayımlanma Tarihi | 15 Aralık 2012 |
Yayımlandığı Sayı | Yıl 2012 Cilt: 4 Sayı: 4 |