Research Article

Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination

Volume: 28 Number: 6 June 28, 2025
EN

Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination

Abstract

Facial masks are often used for the prevention of skin damage, such as skin aging due to free radical activity. The peel-off gel mask is convenient because it can be easily removed after drying without rinsing. Free radical activity can be inhibited by using antioxidants. One of the antioxidants can be derived from natural materials such as binahong. This study aimed to optimize the peel-off gel mask formula containing binahong leaf extract and evaluate the antioxidant activity of the gel mask formula during the storage period. Peel-off gel masks were prepared by combining PVA, CMC-Na, and sodium alginate as gelling agents. A simplex lattice design (SLD) method was used to optimize the peel-off gel mask formula. The optimum formulation was obtained using a combination of 3.5 g PVA, 1.5 g sodium alginate, 5 g propylene glycol, and 0.1 g potassium sorbate. The optimum formulation has an average spreading capacity of 9.2 ± 0.21 cm, adhesion capacity of 1.09 ± 0.33 seconds, viscosity level of 1491.67 ± 10.78 cP, pH of 7.21 ± 0.02, a drying time of 68 ± 6.24 min, tensile strength of 1.792 ± 0.25 MPa, elongation of 68.077% ± 1.14, and antioxidant capacity with inhibition percentage of 55.087% ± 2.87. The peel-off gel mask containing binahong leaf extract meets the good criteria as the peel-off gel mask. Moreover, the characteristics of the optimal formula peel-off gel mask did not change significantly for 4 weeks of storage at 40oC ± 2oC/75%RH ± 5%RH.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Publication Date

June 28, 2025

Submission Date

November 10, 2023

Acceptance Date

February 26, 2024

Published in Issue

Year 2024 Volume: 28 Number: 6

APA
Winingrum, L. A., & Zai, K. (2025). Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. Journal of Research in Pharmacy, 28(6), 1953-1962. https://doi.org/10.29228/jrp.868
AMA
1.Winingrum LA, Zai K. Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. J. Res. Pharm. 2025;28(6):1953-1962. doi:10.29228/jrp.868
Chicago
Winingrum, Listia Ayu, and Khadijah Zai. 2025. “Optimization of Peel-off Gel Mask Formula Containing Binahong (Anredera Cordifolia) Leaf Extract Based PVA CMC- Alginate Combination”. Journal of Research in Pharmacy 28 (6): 1953-62. https://doi.org/10.29228/jrp.868.
EndNote
Winingrum LA, Zai K (July 1, 2025) Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. Journal of Research in Pharmacy 28 6 1953–1962.
IEEE
[1]L. A. Winingrum and K. Zai, “Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination”, J. Res. Pharm., vol. 28, no. 6, pp. 1953–1962, July 2025, doi: 10.29228/jrp.868.
ISNAD
Winingrum, Listia Ayu - Zai, Khadijah. “Optimization of Peel-off Gel Mask Formula Containing Binahong (Anredera Cordifolia) Leaf Extract Based PVA CMC- Alginate Combination”. Journal of Research in Pharmacy 28/6 (July 1, 2025): 1953-1962. https://doi.org/10.29228/jrp.868.
JAMA
1.Winingrum LA, Zai K. Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. J. Res. Pharm. 2025;28:1953–1962.
MLA
Winingrum, Listia Ayu, and Khadijah Zai. “Optimization of Peel-off Gel Mask Formula Containing Binahong (Anredera Cordifolia) Leaf Extract Based PVA CMC- Alginate Combination”. Journal of Research in Pharmacy, vol. 28, no. 6, July 2025, pp. 1953-62, doi:10.29228/jrp.868.
Vancouver
1.Listia Ayu Winingrum, Khadijah Zai. Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVA CMC- alginate combination. J. Res. Pharm. 2025 Jul. 1;28(6):1953-62. doi:10.29228/jrp.868

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