Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodically pretreated boron-doped diamond electrode

Abstract

This paper examined for the first time the possibilities of the usage of the cathodically pretreated borondoped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using squarewave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 μg mL-1 (1.73x10-5 -3.47x10-4 M). A detection limit of 1.21 μg mL-1 (5.06x10-6 M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations.

Keywords

• Salbutamol
• boron-doped diamond electrode
• square-wave adsorptive stripping voltammetry
• pharmaceutical formulations

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