Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey

Nagehan Saltan; Yavuz Bülent Köse; Fatih Göger; Gökalp İşcan

Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey

Abstract

The study aimed to determine the total phenol content of the extracts prepared with different solvents (70%methanol, ethyl acetate, 5% infusion) from the aerial parts of the I. oculus-christi, as well as to evaluate the antioxidant capacity and antimicrobial activity of the plant and to determine the main components responsible for the effect. The total phenolic content of the extracts prepared from the aerial parts of I. oculus-christi was calculated in gallic acid equivalents and the total phenolic content of the species was found to be in the range of 23.8-75.3 mg GAE/g. The highest total phenol content calculated as gallic acid equivalent was detected in the 5% infusion sample. The antioxidant activity of I. oculus-christi was also tested using DPPHˈ free radical scavenging in vitro assay (IC50: 0.092-1.03 mg/mL). The 5% infusion of the plant was shown to be the most effective extract in the antioxidant activity test performed using the DPPHˈ technique. The findings revealed that there is a correlation between total phenol content and antioxidant activity, as numerous research as suggested. By using the microdilution method, extracts from the aerial parts of I. oculus-christi were tested against Candida strains, and the MIC value for C. utilis was found to be 0.03 mg/mL in 5% infusion and ethyl acetate extracts. In terms of evaluating the biological effects obtained, the chemical composition of extracts was analyzed by HPLC-MS/MS, and the main components (5-caffeoylquinic acid, 1,5-dicaffeoylquinic acid, luteolin/kaempferol, apigenin, and rutin) were determined.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Botany

Journal Section

Research Article

Authors

Nagehan Saltan ^*
0000-0002-1207-909X
Türkiye

Yavuz Bülent Köse
0000-0002-3060-7271
Türkiye

Fatih Göger
0000-0002-9665-0256
Türkiye

Gökalp İşcan
0000-0003-1210-0490
Türkiye

Publication Date

June 28, 2025

Submission Date

February 21, 2022

Acceptance Date

April 23, 2022

Published in Issue

Year 2022 Volume: 26 Number: 4

IZ

https://izlik.org/JA59MA62TD

Cite

RIS / Bibtex

APA

Saltan, N., Köse, Y. B., Göger, F., & İşcan, G. (2025). Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey. Journal of Research in Pharmacy, 26(4), 799-808. https://izlik.org/JA59MA62TD

AMA

1.Saltan N, Köse YB, Göger F, İşcan G. Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey. J. Res. Pharm. 2025;26(4):799-808. https://izlik.org/JA59MA62TD

Chicago

Saltan, Nagehan, Yavuz Bülent Köse, Fatih Göger, and Gökalp İşcan. 2025. “Phenolic Profile, Antioxidant and Anticandidal Activities of Inula Oculus-Christi L. From Turkey”. Journal of Research in Pharmacy 26 (4): 799-808. https://izlik.org/JA59MA62TD.

EndNote

Saltan N, Köse YB, Göger F, İşcan G (June 1, 2025) Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey. Journal of Research in Pharmacy 26 4 799–808.

IEEE

[1]N. Saltan, Y. B. Köse, F. Göger, and G. İşcan, “Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey”, J. Res. Pharm., vol. 26, no. 4, pp. 799–808, June 2025, [Online]. Available: https://izlik.org/JA59MA62TD

ISNAD

Saltan, Nagehan - Köse, Yavuz Bülent - Göger, Fatih - İşcan, Gökalp. “Phenolic Profile, Antioxidant and Anticandidal Activities of Inula Oculus-Christi L. From Turkey”. Journal of Research in Pharmacy 26/4 (June 1, 2025): 799-808. https://izlik.org/JA59MA62TD.

JAMA

1.Saltan N, Köse YB, Göger F, İşcan G. Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey. J. Res. Pharm. 2025;26:799–808.

MLA

Saltan, Nagehan, et al. “Phenolic Profile, Antioxidant and Anticandidal Activities of Inula Oculus-Christi L. From Turkey”. Journal of Research in Pharmacy, vol. 26, no. 4, June 2025, pp. 799-08, https://izlik.org/JA59MA62TD.

Vancouver

1.Nagehan Saltan, Yavuz Bülent Köse, Fatih Göger, Gökalp İşcan. Phenolic profile, antioxidant and anticandidal activities of Inula oculus-christi L. from Turkey. J. Res. Pharm. [Internet]. 2025 Jun. 1;26(4):799-808. Available from: https://izlik.org/JA59MA62TD