O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies.

A. Levent Alparslan; Ercüment Karasulu; Gülbeyaz Yıldız Türkyılmaz; Doğan Üvey

O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies.

Abstract

Microemulsions are ideal carriers for poorly soluble substances. They increase the absorption of drugs with low bioavailability. Methotrexate (MTX), which is used internally in cancer and psoriasis and has many side effects and it is less soluble in water and its passage through the skin is problematic due to its high molecular weight. An O/W microemulsion formulation containing MTX has been developed in order to reduce the side effects of the drug, not to have a first pass effect on the liver, to increase its bioavailability in topical use and to provide ease of use to patients. The releasing profiles of the gel formulation, prepared by reducing the fluidity of these formulations by polymers, were investigated through the nylon membrane. Mostly W/O microemulsion systems are available due to design of preparations but in this study O/W microemulsions and gel forms containing MTX were designed for topical use. Innovation side of trials will inspire in vivo studies and clinical studies that may cause less harm to patients dermatologically and provide optimal effect.

Keywords

References

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Türk Farmakopesi(2017) Vol.VI p:4505

Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology

Journal Section

Research Article

Authors

A. Levent Alparslan ^*
Türkiye

Ercüment Karasulu
0000-0002-3992-6201
Türkiye

Gülbeyaz Yıldız Türkyılmaz
0000-0002-8601-0263
Türkiye

Doğan Üvey This is me
0000-0002-4928-6498
Türkiye

Publication Date

June 27, 2025

Submission Date

June 21, 2022

Acceptance Date

November 28, 2022

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA99ME34SA

Cite

RIS / Bibtex

APA

Alparslan, A. L., Karasulu, E., Yıldız Türkyılmaz, G., & Üvey, D. (2025). O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies. Journal of Research in Pharmacy, 27(2), 873-882. https://izlik.org/JA99ME34SA

AMA

1.Alparslan AL, Karasulu E, Yıldız Türkyılmaz G, Üvey D. O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies. J. Res. Pharm. 2025;27(2):873-882. https://izlik.org/JA99ME34SA

Chicago

Alparslan, A. Levent, Ercüment Karasulu, Gülbeyaz Yıldız Türkyılmaz, and Doğan Üvey. 2025. “O/W/Microemulsion/and/Hydrogel/Formulation/of/Methotrexate/and/Comparison/of/Releasing/Studies”. Journal of Research in Pharmacy 27 (2): 873-82. https://izlik.org/JA99ME34SA.

EndNote

Alparslan AL, Karasulu E, Yıldız Türkyılmaz G, Üvey D (June 1, 2025) O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies. Journal of Research in Pharmacy 27 2 873–882.

IEEE

[1]A. L. Alparslan, E. Karasulu, G. Yıldız Türkyılmaz, and D. Üvey, “O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies”., J. Res. Pharm., vol. 27, no. 2, pp. 873–882, June 2025, [Online]. Available: https://izlik.org/JA99ME34SA

ISNAD

Alparslan, A. Levent - Karasulu, Ercüment - Yıldız Türkyılmaz, Gülbeyaz - Üvey, Doğan. “O/W/Microemulsion/and/Hydrogel/Formulation/of/Methotrexate/and/Comparison/of/Releasing/Studies”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 873-882. https://izlik.org/JA99ME34SA.

JAMA

1.Alparslan AL, Karasulu E, Yıldız Türkyılmaz G, Üvey D. O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies. J. Res. Pharm. 2025;27:873–882.

MLA

Alparslan, A. Levent, et al. “O/W/Microemulsion/and/Hydrogel/Formulation/of/Methotrexate/and/Comparison/of/Releasing/Studies”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 873-82, https://izlik.org/JA99ME34SA.

Vancouver

1.A. Levent Alparslan, Ercüment Karasulu, Gülbeyaz Yıldız Türkyılmaz, Doğan Üvey. O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):873-82. Available from: https://izlik.org/JA99ME34SA