Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration

Gülşah Gedik

Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration

Abstract

This study relates to the Alteromonas ferment extract, a by-product of a marine bacteria, Alteromonas macleodii, is used in anti-aging cream formulation. Alteromonas ferment extract is an innovative anti-pollution ingredient that chelates heavy metals and has non-toxic anionic polysaccharides, which are used as thickening or structuring agent in tissue engineering, wound management or drug delivery applications. Aging is a physiological process, it is undesirable especially on the skin. Aging leads to weakening of facial muscles and loss of subcutaneous fat and skin laxity, along with wrinkles, prominent lines and sagging skin. Changes in collagen play an important role in reducing skin elasticity. In this case, fibroblast decreases, matrix metalloproteinase increases (responsible for collagen breakdown), and glycosaminoglycans decrease. The objective of the study was to evaluate effects of the anti-aging cosmetic face cream including Alteromonas ferment extract on human dermal fibroblast cells. The outcomes of the characterization analysis have indicated the development of a successful cream formulation with optimum characteristics. No microbial growth was observed. Given the results obtained in the tested conditions, the anti- aging cream is not cytotoxic against fibroblasts 0.5% or less concentration. The dilutions of 0.1% and 0.2% were chosen for evaluation of collagen concentration, because they were the most appropriate concentrations in terms of solubility and lack of cytotoxicity. The treatment with anti-aging cream formulation at 0.1% and 0.2% increased collagen synthesis 57% and 67%, respectively in cell culture.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biotechnology

Journal Section

Research Article

Authors

Gülşah Gedik ^*
0000-0003-4147-6729
Türkiye

Publication Date

June 27, 2025

Submission Date

February 21, 2023

Acceptance Date

March 2, 2023

Published in Issue

Year 2023 Volume: 27 Number: 2

IZ

https://izlik.org/JA25KJ48JB

Cite

RIS / Bibtex

APA

Gedik, G. (2025). Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration. Journal of Research in Pharmacy, 27(2), 903-912. https://izlik.org/JA25KJ48JB

AMA

1.Gedik G. Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration. J. Res. Pharm. 2025;27(2):903-912. https://izlik.org/JA25KJ48JB

Chicago

Gedik, Gülşah. 2025. “Formulation of an Anti-Aging Cream Containing Alteromonas Ferment Extract and Evaluation of the Effect on Collagen Concentration”. Journal of Research in Pharmacy 27 (2): 903-12. https://izlik.org/JA25KJ48JB.

EndNote

Gedik G (June 1, 2025) Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration. Journal of Research in Pharmacy 27 2 903–912.

IEEE

[1]G. Gedik, “Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration”, J. Res. Pharm., vol. 27, no. 2, pp. 903–912, June 2025, [Online]. Available: https://izlik.org/JA25KJ48JB

ISNAD

Gedik, Gülşah. “Formulation of an Anti-Aging Cream Containing Alteromonas Ferment Extract and Evaluation of the Effect on Collagen Concentration”. Journal of Research in Pharmacy 27/2 (June 1, 2025): 903-912. https://izlik.org/JA25KJ48JB.

JAMA

1.Gedik G. Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration. J. Res. Pharm. 2025;27:903–912.

MLA

Gedik, Gülşah. “Formulation of an Anti-Aging Cream Containing Alteromonas Ferment Extract and Evaluation of the Effect on Collagen Concentration”. Journal of Research in Pharmacy, vol. 27, no. 2, June 2025, pp. 903-12, https://izlik.org/JA25KJ48JB.

Vancouver

1.Gülşah Gedik. Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(2):903-12. Available from: https://izlik.org/JA25KJ48JB