Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios

Abdulloh Suyuti; Esti Hendradi; Tutiek Purwanti

Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios

Abstract

Nanostructured Lipid Carriers (NLC) could be a good choice for dermal or transdermal delivery. It could dissolve lipophilic drugs, solve the problem of low skin permeation, and also be photoprotective. The composition of constituent materials and the ratio between solid lipid and liquid lipid influence the characteristics and stability of NLC. Compritol 888 ATO and Miglyol 812 have been widely studied for the development of dermal or transdermal preparation, but this combination has not been studied for use in Coenzyme Q10 loaded NLC systems. This study is to determine the effect of different lipid ratios of Compritol 888 ATO as solid lipid and Miglyol 812 as liquid lipid on the physicochemical characteristics, entrapment efficiency, and stability of NLC loaded Coenzyme Q10 using the High Shear Homogenization method. Three different lipid ratios were used in the NLC formulation, in which the ratio of Compritol 888 ATO : Miglyol 812 were 70:30, 80:20, and 90:10, respectively. NLC was characterized for FTIR spectra, differential scanning calorimetry, organoleptic, particle size, polydispersity index, zeta potential, pH, viscosity, entrapment efficiency, and evaluated for stability using the real-time method for 1 month. The result showed that the polydispersity index, zeta potential, and pH value were not significantly impacted by the various ratios of lipid. On the other hand, it had a considerable impact on three different formulas for particle size, viscosity, and entrapment efficiency. There were produced NLC with small particle size, low crystallinity, and high Coenzyme Q10 entrapment efficiency.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Delivery Technologies

Journal Section

Research Article

Authors

Abdulloh Suyuti This is me
0000-0002-4782-9030
Indonesia

Esti Hendradi ^*
0000-0002-8216-8549
Indonesia

Tutiek Purwanti This is me
Indonesia

Publication Date

June 28, 2025

Submission Date

October 31, 2022

Acceptance Date

January 10, 2023

Published in Issue

Year 2023 Volume: 27 Number: 3

IZ

https://izlik.org/JA73JB99KG

Cite

RIS / Bibtex

APA

Suyuti, A., Hendradi, E., & Purwanti, T. (2025). Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios. Journal of Research in Pharmacy, 27(3), 1134-1142. https://izlik.org/JA73JB99KG

AMA

1.Suyuti A, Hendradi E, Purwanti T. Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios. J. Res. Pharm. 2025;27(3):1134-1142. https://izlik.org/JA73JB99KG

Chicago

Suyuti, Abdulloh, Esti Hendradi, and Tutiek Purwanti. 2025. “Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 With Different Lipid Ratios”. Journal of Research in Pharmacy 27 (3): 1134-42. https://izlik.org/JA73JB99KG.

EndNote

Suyuti A, Hendradi E, Purwanti T (June 1, 2025) Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios. Journal of Research in Pharmacy 27 3 1134–1142.

IEEE

[1]A. Suyuti, E. Hendradi, and T. Purwanti, “Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios”, J. Res. Pharm., vol. 27, no. 3, pp. 1134–1142, June 2025, [Online]. Available: https://izlik.org/JA73JB99KG

ISNAD

Suyuti, Abdulloh - Hendradi, Esti - Purwanti, Tutiek. “Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 With Different Lipid Ratios”. Journal of Research in Pharmacy 27/3 (June 1, 2025): 1134-1142. https://izlik.org/JA73JB99KG.

JAMA

1.Suyuti A, Hendradi E, Purwanti T. Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios. J. Res. Pharm. 2025;27:1134–1142.

MLA

Suyuti, Abdulloh, et al. “Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 With Different Lipid Ratios”. Journal of Research in Pharmacy, vol. 27, no. 3, June 2025, pp. 1134-42, https://izlik.org/JA73JB99KG.

Vancouver

1.Abdulloh Suyuti, Esti Hendradi, Tutiek Purwanti. Physicochemical Characteristics, Entrapment Efficiency, and Stability of Nanostructured Lipid Carriers Loaded Coenzyme Q10 with Different Lipid Ratios. J. Res. Pharm. [Internet]. 2025 Jun. 1;27(3):1134-42. Available from: https://izlik.org/JA73JB99KG