Development and validation of an electroanalytical method for the quantification of antiviral molnupiravir and its application to the pharmaceutical sample

Year 2025, Volume: 29 Issue: 4, 1746 - 1752, 05.07.2025

Ali Kemal Ateş

https://doi.org/10.12991/jrespharm.1734697

Abstract

In this study, a sensitive, fast, economical, and practical voltammetric method was developed for analysing molnupiravir (MLP), an antiviral drug extensively used during the COVID-19 pandemic, without the need for modifying the glassy carbon (GC) electrode surface. During the electroanalysis, an oxidation peak for MLP was detected at 0.72555 V on the GC electrode. The method exhibited linearity across a concentration range of 1 - 250 µM for MLP with 0.33 µM of detection limit. Furthermore, with a 99.81% recovery from its pharmaceutical form, the method's effectiveness was validated. These results strongly indicate that this method is suitable for routine quality control of molnupiravir and may serve as a model for analysing other antiviral drugs.

Keywords

Antiviral agent , molnupiravir , electroanalytical chemistry , differential pulse voltammetry

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