MANUSCRIPT PREPARATION

Authors must use our manuscript template which is accessible at our website and article submission system (https://www.jrespharm.com/static.php?id=7). This will facilitate manuscript preparation and may prevent delays due to returning of your article at technical check stage. Manuscripts should contain the following elements in the following order:
Title
Author names, affiliations
Abstract
Keywords
Introduction
Results
Discussion
Conclusion
Materials and Methods
Acknowledgements
Authorship statement
Conflict of interest statement
References

Tables and figures should be placed where they are related, not in a separate section at the end of the article.

5.1. TITLE

Title should be concise and informative. Titles are often used in information-retrieval systems. Avoid abbreviations and formulae, where possible. Titles are of great importance for current awareness and for information retrieval. The wording of titles should be chosen carefully to provide information on the contents and to function as "points of entry" for information retrieval. Symbols, formulas, or arbitrary abbreviations should not be included in the title, except chemical symbols to indicate the structure of isotopically labeled compounds. Full title must be in sentence case. The title of the manuscript must be written in lower case except for the first word and proper nouns.


5.2. AUTHOR NAMES AND AFFILIATIONS

Author names must be given in full, with surnames (family names) all in capitals.
Where names may be ambiguous (e.g., a double name, or possible confusion about first/last names), please indicate this clearly. Present the authors' affiliation addresses (where the actual work was done) below the names. Indicate all affiliations with a lowercase superscript number immediately after the author's name and in front of the appropriate address. Author addresses must be given in English in the following order: Department, Faculty, University, City, Country, with numbers in superscript after each author name to indicate his/her address. Provide the full postal address of each affiliation, including the country name for each author.


5.2.1. Present/permanent address

If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.

5.2.2. Corresponding Author

You should designate one author to act as corresponding author. Note that this is the person who will receive correspondence from Journal of Research in Pharmacy editorial office and needs to be the person who will appear as corresponding author on the paper if accepted.
The manuscript has to be submitted online by the person who is in charge of correspondence at all stages of the editorial process, production, and post-publication. Ensure that phone/fax numbers with country and area codes) are provided, in addition to the e-mail address (preferably an institutional e-mail address) and the complete postal address. Contact details of the other authors must be kept up to date by the corresponding author.

5.3. ABSTRACT

A concise and factual abstract, which is unstructured, is required. The abstract is limited to 250 words or less for research and review articles and, 200 words or less for commentaries. The abstract should state briefly the purpose of the research, experimental approach, the principal results and major conclusions. An abstract is often presented separately from the article, so the text should be comprehensible when read alone. For this reason, references should be avoided.
The use of numbers in the abstract identifying compounds, formulas, tables or references and non-standard or uncommon abbreviations should be avoided. However, if essential, they must be defined at their first mention in the abstract.


5.4. KEY WORDS

Each submission must be accompanied by a minimum of four to a eight keywords that reflect the scientific content of your manuscript for subject indexing at the end of the abstract. The keywords should be listed in full without abbreviations. Be sparing with abbreviations: only abbreviations firmly established in the field may be eligible.


5.5. INTRODUCTION

In this section, the authors should state the objectives of the work, define the scope of your paper, summarize relevant work to the study being reported and provide an adequate background. A detailed literature survey or a summary of the results should be avoided. It should not be a review of the subject area, but should finish with a clear statement of the question being addressed. The introduction must be designed to inform the reader of the rationale and significance of the study.


5.6. RESULTS AND DISCUSSION 5.6.1.

Results

Results should be clear and concise. Text, tables and figures must show minimal overlap, and must be internally consistent. Tables and figures should be designed to maximize the presentation and comprehension of the experimental data. Attention should be paid to the matter of significant figures (usually, no more than three). The same data should not be presented in more than one figure or in both a figure and a table. As a rule, interpretation of the results should be reserved for the discussion section of a Research Article, but under some circumstances it may be desirable to combine results and discussion in a single section.

5.6.2. Discussion

The Results and Discussion sections may be combined. Avoid extensive citations and discussion of published literature. The purpose of the discussion is to interpret significance of the results and to relate them to existing knowledge in the field in as clear and brief a fashion as possible. Information given elsewhere in the manuscript should not be repeated in the discussion. Extensive reviews of the literature should be avoided.


5.7. CONCLUSIONS

The main conclusions of the study should be presented in a short Conclusions section, which stands alone. You should explain whether your findings supported your hypothesis. Avoid using references in conclusion section.


5.8. MATERIALS AND METHODS

Methods already published should be indicated by a reference: only relevant modifications should be described.
The experimental procedures should be described in sufficient detail to enable others to repeat the experiments. Names of products and manufacturers (with locations) should be supplied for all mentioned equipment, instruments, chemicals, etc. Brand names may be used only once in the manuscript. For subsequent designation, use "formulation A", product B", etc. Novel experimental procedures should be described in detail, but published procedures should merely be referred to by literature citation of both the original and any published modifications. The purity of key compounds and descriptions(s) of the method(s) used to determine purity should be included in this section. For buffers, use terminology such as "20 mM potassium phosphate buffer (pH 7.7) containing...". Also, state w/v or v/v when appropriate. Identification of and precautions for handling hazardous chemicals and dangerous procedures should be placed at the beginning of the section. An example would be " Caution: The following chemicals are hazardous and should be handled carefully; (list of chemicals and handling procedures or references) ". Manuscripts containing data generated from animal and/or human studies must specify the committee and the institution that approved the experimental protocols used to generate these data.

5.8.1. Characterization of the synthesized compounds

Sufficient experimental information should be given by the authors. A melting point range should be reported for every crystalline solid product, together with the solvent from which it was recrystallized, and a description of the material e.g. “yellow needles, mp 123-124 ºC (from ethanol)”. For all synthesized compounds (new or previously reported), evidence to confirm both identity and purity have to be provided. Evidence for the identity of new compounds should include both elemental analysis and 1H NMR data. 13C NMR data of at least some key structures should be present. Evidence for the identity of new compounds should include, 1H NMR data and either HRMS (resolution 0.001 m/z unit or better) or elemental analysis data to support the molecular formula assignment. In case HRMS is preferred to elementel analysis, HPLC chromatograms should be provided as supplementary material.
To facilitate reviewing process, the authors are encouraged to submit a list of compounds as a separate file. In this list, previously reported and new compounds should be classified. Chemical structures and SMILES codes of all compounds should be supplied, together with the names of the characterization techniques used for each compound. This form should be uploaded as Supplementary material (for reviewing purposes only).


5.9. ACKNOWLEDGEMENTS

Collate acknowledgements in a separate section at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or otherwise. This section should acknowledge financial support, help from a lab technician or statistician, advice from colleagues, gifts, etc. Permission must be received from persons whose contribution to the work is acknowledged in the manuscript.


5.10. AUTHORSHIP STATEMENT

Author contributions should be written right before conflict of interest statement, in accordance with JRP – Copyright Transfer Agreement signed by the authors. Please use initials instead of full names. It should appear as follows :
Author contributions: Concept – İ.K., E.T.; Design – İ.K., E.T.; Supervision – E.T.; Resource – İ.K.; Materials – N.K., A.D.; Data Collection &/or Processing - N.K., A.D.; Analysis &/or Interpretation - N.K., A.D.; Literature Search – İ.K., E.T., N.K., A.D.; Writing – E.T., İ.K.; Critical Reviews – İ.K., E.T., N.K., A.D.


5.11. CONFLICT OF INTEREST STATEMENT

Journal of Research in Pharmacy requires and encourages the authors and the reviewers involved in the evaluation process of submitted manuscripts to disclose any existing or potential conflicts of interests, including financial, consultant, and institutional, that might lead to potential bias or a conflict of interest. Any financial grants or other support received for a submitted study from individuals or institutions should be disclosed to the Editorial Board.
If there is no conflict of interest to be declared by any of the authors, write “The authors declared no conflict of interest” in the manuscript.


5.12. REFERENCES 5.12.1. Citation in text

While citing publications, preference should be given to the latest, most up-to-date publications. References should conform to Vancouver style and be numbered consecutively in the order in which they are cited in the text. Cite in the text by the appropriate Arabic numeral enclosed in square brackets, e.g., [1], [2-5], etc. Authors are responsible for the accuracy of references. All references cited in the manuscript must appear in the list of references at the end and all references listed in the reference list must be cited in the manuscript. Do not include personal communications, unpublished data, or other unpublished materials as references. In the case of cited publications in languages other than English, the published English title should be provided if one exists, with an annotation such as “(article in Turkish with an abstract in English)”. If the publication was not published with an English title, provide the original title only; do not provide a self-translation.

5.12.2. Web references

Although web references is not recommended by Journal of Research in Pharmacy, some circumstances might be considered as exceptional cases. These are: Websites of governmental organizations (ie. ministries of health, FDA), international organizations (ie. WHO, EMA, ICH, EFMC), online calculation tools (ie. Molinspiration, VCCLAB).


5.12.3. Formatting

Journal titles should be abbreviated in accordance with the journal abbreviations in Thomson Reuters Web of Science, Index Medicus/ MEDLINE/PubMed. For all journal articles (including articles in press) in the reference list, the DOI numbers should be provided (ie. http://dx.doi.org/10.1016/j.ejmech.2016.05.017). The reference styles for different types of publications are presented in the following examples.


5.12.4. Examples

Reference to a journal publication:

[1] Tatar E, Küçükgüzel İ, Daelemans D, Talele TT, Kaushik-Basu N, De Clercq E, Pannecouque C. Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1. Arch Pharm (Weinheim). 2013; 346(2): 140-153. http://dx.doi.org/10.1002/ardp.201200311.

[2] Tatar E, Karakuş S, Küçükgüzel ŞG, Öktem Okullu S, Ünübol N, Kocagöz T, De Clercq E, Andrei G, Snoeck R, Pannecouque C, Kalaycı S, Şahin F, Sriram D, Yogeeswari P, Küçükgüzel İ. Design, synthesis, and molecular docking studies of a conjugated thiadiazole-thiourea scaffold as antituberculosis agents. Biol Pharm Bull. 2016; 39(4): 502-515. http://dx.doi.org/10.1248/bpb.b15-00698.

[3] Kulabaş N, Bingöl Özakpınar Ö, Özsavcı D, Leyssen P, Neyts J, Küçükgüzel İ. Synthesis, characterization and biological evaluation of thioureas, acylthioureas and 4-thiazolidinones as anticancer and antiviral agents. J Res Pharm. 2017; 21(2): 371-384. http://dx.doi.org/10.12991/marupj.300913.

Reference to a book:

2. Silverman RB, The Organic Chemistry of Drug Design and Drug Action, third ed., Elsever, Burlington, MA, USA 2014.

Reference to a chapter in an edited book:

3. Şener G, Sakarcan A, Yeğen B. Melatonin as a radioprotective agent. In: Montilla P, Túnez I. (Eds). Melatonin: Present and Future. Nova Science Publishers, Inc., New York, 2008, pp.127-142.


Theses

4. Tatar E. PhD Thesis. Synthesis and characterization of novel 1,3-thiazolidine-4-ones derived from 2-(aroylamino)-3-methyl butyric acid hydrazide. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Haydarpaşa, İstanbul, Turkey, 2009.

Reference to a website:

5. VCCLAB, Virtual Computational Chemistry Laboratory. http://www.vcclab.org (accessed March 18, 2017).

6. PASS (Prediction of Activity Spectra for Substances) program. http://www.way2drug.com/passonline(accessed July 18, 2015).

7. WHO Global tuberculosis report 2013. http://apps.who.int/iris/bitstream/10665/91355/1/9789241564656_eng.pdf?ua=1, (accessed July 18, 2015).

5.13. TABLES

Please submit tables as editable text and not as images. Tables should be placed next to the relevant text in the article. They should not be given on separate page(s) after the references. Number tables consecutively in accordance with their appearance in the text and place any table footnotes below the table body. Table headings should be given above the table and written in sentence case. Be sparing in the use of tables and ensure that the data presented in them do not duplicate results described elsewhere in the article. Please avoid using vertical rules.


5.14. FIGURES

All artworks, figures, images, illustrations, graphics, photos, pictures, plots and schemes should be labeled as Figures. Figures must be submitted both in the manuscript and as separate files. Inclusion of the figures in the manuscript should be done using add pictures command under insert tab – do NOT use copy and paste function. All tables and figures must have a caption and/or legend and be numbered (e.g., Table 1, Figure 2), unless there is only one table or figure, in which case it should be labelled “Table” or “Figure” with no numbering. Captions must be written in sentence case (e.g., Physical and spectral data of the synthesized compounds.). The font used in the figures should be Times New Roman. A caption should comprise a brief title (not on the figure itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.

All tables and figures must be numbered consecutively as they are referred to in the text. Please refer to tables and figures with capitalisation and unabbreviated (e.g., “As shown in Figure 2…”, and not “Fig. 2” or “figure 2”). The tables and figures themselves should be given in the running text. They should not be given at the end of the text only, after the references.
To ensure the highest print quality, your figures should be submitted in either TIFF or JPEG format at the highest possible resolution (300 dpi or higher). The authors should obtain written permission from the respective publishers to reproduce any images from other sources, even if they are quoted from their previous papers.


5.14.1. Image manipulation

Whilst it is accepted that authors sometimes need to manipulate images for clarity, manipulation for purposes of deception or fraud will be seen as scientific ethical abuse and will be dealt with accordingly. For graphical images, this journal is applying the following policy: no specific feature within an image may be enhanced, obscured, moved, removed, or introduced. Adjustments of brightness, contrast, or color balance are acceptable if and as long as they do not obscure or eliminate any information present in the original. Nonlinear adjustments (e.g. changes to gamma settings) must be disclosed in the figure legend.

Please do not:

Supply files that are optimized for screen use (e.g., GIF, BMP, PICT, WPG); these typically have a low number of pixels and limited set of colors;
Supply files that are too low in resolution;
Submit graphics that are disproportionately large for the content.

Table 1. Limitations of JRP for each manuscript type.



Word limit
(main text only)

Word limit (Abstract)

Reference limit

Table limit

Figure limit

Keyword limit

Research Article

max. 5500

300

Max. 80

Max. 8

Max. 8

4-8

Review Article

No limits

250

Min. 50

No limits

No limits

4-8

Commentary

max. 2500

200

Max. 30

Max. 4

Max. 4

Max. 6

Letter to Editor

max. 1000

No abstract

Max. 10

No tables

No figures

No keywords