MİKROAKIŞKAN CİHAZ KULLANARAK POLİMERİK MİKROBALONCUK/NANOPARTİKÜLLERİN ÜRETİM VE KARAKTERİZASYONU

Abstract

Son yıllarda, biyomedikal uygulamalarda farklı morfolojilere sahip polimerik mikro/nano partiküller kontrollü ilaç salımı gibi birçok uygulamadaki potansiyelleri nedeniyle ilgi görmektedir. Bu çalışmada, polimer kaplı mikrobaloncuklardan nanopartiküller üretmek için T-bağlantılı mikroakışkan cihaz kullanılmıştır. Mikrobaloncukların ve nanopartiküllerin morfolojisi ve yapısı optik mikroskop, taramalı elektron mikroskobu (SEM) ve Fourier Dönüşümlü Kızıl Ötesi Spektrometresi (FT-IR) kullanılarak üretim işleminden sonra incelendi. Elde edilen mikrobaloncukların ve nanopartiküllerin çapı sırasıyla 104 ± 91 μm ve 116 ± 13 nm idi. Solüsyonun akış hızının nanopartiküllerin çapı üzerinde önemli bir etkiye sahip olduğu görülmüştür. Ortaya çıkan bu sonuçlar, biyomedikal tedavide hücre nakli, ileri terapötik uygulamalar ve gıda endüstrisi gibi birçok uygulama için çok yararlı olacaktır.

Keywords

• Mikrobaloncuk
• Polimerik nanopartikül
• Mikroakışkan cihaz
• Polivinil alkol

Production and Characterization of Polymeric Microbubble / Nanoparticles Using a Microfluidic Device

Abstract

In recent years, polymeric micro/nanoparticles with different morphologies in biomedical applications have gained attention due to their potential in many applications such as controlled drug release. In this study, a T-junction microfluidic device was used to produce nanoparticles from polymer- coated microbubbles. The morphology and structure of microbubbles and nanoparticles were performed after the production process using optical microscopy, scanning electron microscopy (SEM), and Fourier- transform infrared spectroscopy (FT-IR). The diameter of the produced microbubbles and nanoparticles was 104 ± 91 μm and 116 ± 13 nm, respectively. The flow rate of the solution was found to have a significant effect on the diameter of the nanoparticles. These results can be very useful for many applications such as advanced therapeutic applications, cell transplantation in biomedical therapy, and the food industry.

Keywords

• Microbubble
• Polymeric nanoparticle
• Microfluidic device
• Polyvinyl alcohol

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