Akciğer Kanserli Hastalarda Serum ve Bronkoalveolar Lavaj Sıvısında Vasohibin-1 Düzeylerinin Belirlenmesi

Abstract

Amaç:Akciğer kanseri tüm dünyada kanser olgularının %17’sinden, kanser ölümlerinin ise %23’ünden sorumludur. Vasohibin 1 (VASH-1) endotel hücreleri tarafından sentezlenen bir anjiyogenez inhibe edici faktördür. Bu çalışmada akciğer kanserli hastalarda, bronkoalveolar lavaj (BAL) ve serum VASH-1 düzeylerinin incelenmesi amaçlandı. Gereç ve Yöntem: Bu çalışmaya toplam 82 hasta katıldı. Bunlardan 39'u benign akciğer hastalığı ve 43'ü malign akciğer kanserine sahipti. Serum ve BAL VASH-1 düzeyleri, enzim bağlı immünosorbent analizi (ELISA) kullanılarak ölçüldü. Bulgular: Akciğer kanseri grubunda, BAL VASH1 düzeyleri, benign akciğer hastalığı olan gruptan anlamlı derecede düşüktü (p=0,032). Ancak serum VASH-1 düzeyleri açısından her iki grup arasında anlamlı bir fark yoktu (p=0,206). Malign ve benign vakalarda serum VASH-1 ile BAL VASH-1 düzeyleri arasında istatistiksel olarak anlamlı, orta dereceli, pozitif bir korelasyon vardı (benign r= r=0.442, p=0.005; malign r=0.364, p=0.016). Akciğer kanserli hastalar patolojik ‘stage’ lerine ve histolojik tiplerine göre ayrıldığında, evreler ve histolojik tipler arasında serum ve BAL sıvısı VASH1 konsantrasyonları bakımından anlamlı bir farklılık yoktu. Sonuç: BAL VASH-1 konsantrasyonları, akciğer kanseri hastalarında benign akciğer hastalığı olan bireylere kıyasla azaldı. Elde edilen sonuçlar ışığında, BAL VASH-1 konsantrasyonlarının benign ve malign akciğer hastalıklarını ayırt etmede faydalı olabileceği düşünülmüştür.

Keywords

• Akciğer kanseri
• Anjiogenez
• Bronkoalveolar lavaj sıvısı
• Metastaz
• Vazohibin-1

Project Number

PRJ2014/13

Determining the Vasohibin-1 Levels of the Serum and Broncoalveolar Lavage Fluid in the Patients with Lung Cancer”

Abstract

Objective: Lung cancer constitutes 17% of all cancer cases and accounts for 23% of the deaths caused by cancer all over the world. Vasohibin-1 (VASH-1) is an angiogenesis-inhibiting factor synthesized by endothelial cells (ECs). This study aimed to examine the VASH-1 levels of the bronchoalveolar lavage (BAL) and serum in the patients with lung cancer. Material and Method: A total of 82 patients participated in this study. 39 and 43 of them had a benign lung disease and lung cancer, respectively. The VASH-1 levels of serum and BAL were measured using the Enzyme-Linked Immunosorbent Assay (ELISA). Results: The BAL VASH-1 levels of the patients in the lung cancer group were found to be statistically significantly lower than those of the patients in the benign lung disease group (p=0.032). No statistically significant difference was found between the individuals with lung cancer and benign lung disease in terms of the serum VASH-1 concentration (p=0.206). A statistically significantly moderate positive correlation was found between the serum and BAL VASH-1 levels in the benign and malignant cases (benign r=0.442, p=0.005; malignant r=0.364, p=0.016). When the lung cancer patients were categorized into pathological stages and histological types, no significant difference was found between the stages and histological types in terms of the serum and BAL fluid VASH-1 concentrations. Conclusions: BAL VASH-1 concentrations decreased in the lung cancer patients compared to the individuals having a benign lung disease. Considering the results reached in this study, it was thought that the BAL VASH-1 concentrations might be beneficial in distinguishing between the benign and malignant lung diseases.

Keywords

• Angiogenesis
• broncoalveolar lavage fluid
• lung cancer
• metastasis
• vasohibin-1.

Supporting Institution

Scientific Research Project of Ataturk University

Project Number

PRJ2014/13

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