COVID-19 hastalarında D vitamini düzeyinin klinik durumla olan ilişkisi

Abstract

Amaç: Vitamin D, mukozal bariyerlerin bütünlüğünün korunmasında, doğal ve kazanılmış bağışıklıkta önemli rol oynar. COVID-19 pandemisinde, virüsün varyantları olsa veya aşılanmış olsanız bile, hastalığın ağırlaşmasında veya hafifletilmesinde kişisel bağışıklığın gücü çok önemlidir. Gereç ve Yöntem: Bu çalışmada hastanemize COVID-19 nedeniyle başvuran ayaktan ve yatarak tedavi gören hastaların klinik seyri ile D vitamini düzeyleri arasındaki ilişkiyi araştırdık. 47 ayaktan ve 47 yatan hasta olmak üzere toplam 94 hasta çalışmaya dahil edildi. Bulgular: Her iki grubun ortalama yaş ve cinsiyet dağılımları benzerdi. Hastanemizde COVID-19 nedeniyle takip edilen 94 hastanın sadece 7'sinde D vitamini seviyeleri normal bulundu. D vitamini düzeyi ≥30 olan hastalar, "<10" ve "10-29.9" olanlardan anlamlı derecede düşüktü (her biri için p<0.01). D vitamini düzeyi <10 olan hastanede yatan hastalar (%71), D vitamini düzeyi ≥30 olanlardan (%0) anlamlı olarak daha yüksekti. Ek olarak, D vitamini düzeyi <10 olan ayaktan hastalar (%29), D vitamini düzeyi ≥30 olanlardan (%100) anlamlı olarak daha düşüktü. Sonuç: D vitamini eksikliğinin komorbiditesi olmayan hastalarda bile COVID-19'un şiddetli klinik seyri ile ilişkili olabileceğini ve ayrıca COVID-19'da ölümle sonuçlanan predispozan faktörlerden biri olabileceğini gösterdik. Veriler, COVID-19 salgını sırasında D vitamini takviyelerine devam etmenin çok önemli olduğunu gösteriyor.

Keywords

• D vitamini
• COVID-19
• klinik seyir
• yatan hastalar
• ayaktan hastalar

The Effect of Vitamin D Level on the Clinical Situation in COVID-19 Patients

Abstract

Objective: Vitamin D plays an important role in maintaining the integrity of mucosal barriers and in natural and acquired immunity. In the COVID-19 pandemic, the strength of personal immunity is very important in the severe or lightening of the disease, even if there are variants of the virus or if you are vaccinated. Methods: In this study, we investigated the relationship between the clinical course and vitamin D levels of outpatient and inpatient follow-up patients admitted to our hospital due to COVID-19. A total of 94 patients, 47 outpatients and 47 inpatients, were included in the study. Result: The mean age and gender distributions of both groups were similar. Vitamin D levels were found to be normal in only 7 of 94 patients who were followed up in our hospital due to COVID-19. Patients with vitamin D levels ≥30 were significantly lower than those with "<10" and "10-29.9" (p<0.01 for each). Hospitalized patients (71%) with vitamin D levels <10 were significantly higher than those (0%) with vitamin D levels ≥30. Additionally, the outpatients (29%) with vitamin D levels <10 were significantly lower than those (100%) with vitamin D levels ≥30. Conclusion: We showed that vitamin D deficiency may be associated with the severe clinical course of COVID-19, even in patients without comorbidities, and may also be one of the predisposing factors resulting in death in COVID-19. The data suggest that it is crucial to continue vitamin D supplements during the COVID-19 pandemic.

Keywords

• Vitamin D
• COVID-19
• clinical course
• inpatients
• outpatients

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