Investigation of the relationship between vitamin D and peripheral inflammatory parameters in children with attention deficit and hyperactivity disorder

Abstract

Objective: We aimed to investigate the effects of vitamin D and some nutritional factors such as vitamin B12, folate, homocysteine, and ferritin, which play a role in the pathogenesis of attention deficit and hyperactivity disorder (ADHD), on inflammation, which is also claimed to play a role in the pathogenesis of ADHD. Materials and methods: 39 ADHD and 39 healthy controls were compared with similar age, gender and BMI. The severity of the disease was evaluated with the Turgay ADHD scale. Inflammatory and nutritional parameters were measured routinely. Results: In the patient group, Vitamin D was found to be significantly lower (p<0.001), while homocysteine was found to be significantly higher (p=0.003). CRP and MPV values among inflammatory parameters were found to be significantly higher (p<0.001 for both). No significant correlations were found between nutritional factors and inflammatory parameters (p>0.05 for all). Conclusion: It can be suggested that low levels of vitamin D and high levels of homocysteine, which is related to single carbon metabolism, may play a role in the pathogenesis of ADHD. High levels of some inflammatory values may also indicate the role of inflammation in the pathogenesis of ADHD. No significant relationship was found between nutritional and inflammatory parameters. However, considering the limitations of the study, further research is needed on this subject.

Keywords

• vitamin D
• nutrition
• inflammation
• peripheral inflammatory markers
• attention deficit and hyperactivity disorder
• one-carbon metabolism

Dikkat Eksikliği ve Hiperaktivite Bozukluğu Bulunan Çocuklarda Vitamin D ile Periferal İnflamatuar Parametreler Arasındaki İlişkinin Araştırılması

Abstract

Amaç: Dikkat eksikliği ve hiperaktivite bozukluğu (DEHB) patogenezinde rol oynayan vitamin D ile vitamin B12, folat ve homosistein, ve ferritin gibi bazı nütrisyonel faktörlerin, yine DEHB patogenezinde rol oynadığı ileri sürülen inflamasyon üzerine olan etkileri araştırılmasını hedefledik. Gereç ve yöntemler: 39 DEHB bulunan ve 39 sağlıklı kontrol grubu yaş, cinsiyet ve BMI benzer olacak şekilde karşılaştırıldı. Turgay DEHB ölçeği ile hastalığın şiddeti değerlendirildi. Rutin olarak inflamatuar ve nütrisyonel parametreler ölçüldü. Bulgular: Hasta grubunda, Vitamin D anlamlı olarak düşük bulunurken (p<0.001), homosistein ise anlamlı olarak yüksek bulunmuştur (p=0.003). İnflamatuar parametreler içinde CRP ve MPV değerleri anlamlı olarak yüksek bulunmuştur (ikisi için p<0.001). Nütrisyonel faktörler ile inflamatuar parametreler arasında anlamlı korelasyonlar tespit edilmemiştir (hepsi için p>0.05). Sonuç: Vitamin D’nin ve tek karbon metabolizması ile ilgili olan homosistein yüksekliğinin DEHB patogenezinde rol oynayabileceği düşünülebilir. Bazı inflamatuar değerlerin yüksek olarak bulunması da DEHB patogenezinde inflamasyonun rolüne işaret edebiliri. Nütrisyonel ve inflamatuar parametreler arasında anlamlı bir ilişki bulunmamıştır. Fakat çalışmanın kısıtlılıkları göz önüne alındığında bu konuda ileri araştırmalara ihtiyaç duyulmaktadır.

Keywords

• vitamin D
• nütrisyon
• inflamasyon
• periferal inflamatuar belirteçler
• dikkat eksikliği ve hiperaktivite bozukluğu
• tek karbon metabolizması

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