Prematür Ejakülasyon Tanılı Bireylerde Karar Verme ve Dürtüselliğin Değerlendirilmesi
Year 2023,
, 422 - 428, 20.10.2023
Serkan Aksu
,
Harun Bal
,
İlker Akarken
,
Hasan Deliktaş
,
Hayrettin Şahin
Abstract
Amaç:
Yaşamboyu Prematür Ejakülasyon (PE) etiyolojisinde psikolojik, nörobiyolojik, otonomik ve genetik faktörler gibi farklı mekanizmalar rol oynayabilir. Kortikal aktivite değişiklikleri bildirilmiş olsa da, PE ile dürtüsellik/karar verme arasındaki ilişki bugüne kadar çok az çalışılmıştır. Bu çalışma, yaşam boyu PE'si olan bireylerde ilk kez dürtüsellik ve riskli karar vermeyi değerlendirmeyi amaçlamaktadır.
Gereç ve Yöntem:
Uluslararası Cinsel Tıp Derneği (ISSM-2014) kriterlerine göre 26 yaşamboyu PE hastası teşhis edildi ve 26 sağlıklı gönüllü çalışmaya alındı. Prematür Ejakülasyon Tanısal Aracı (PEDT), Uluslararası Erektil Fonksiyon İndeksi (IIEF), Barratt Dürtüsellik Ölçeği-11 (BIS-11), Hasta Sağlık Anketi-9 (PHQ-9), Balon Analog Risk Görevi (BART) ve Parasal Seçim Anketi-27 (MCQ-27) uygulandı.
Bulgular:
Örneklemin yaş ortalaması 37.28 (18-55) idi. Riskli karar verme ve dürtüsellik açısından gruplar arasında fark bulunmadı.
Sonuç:
Yaşam boyu PE hastalarında dürtüsellikte ve riskli karar vermede herhangi bir değişiklik bulunmadı. Dürtüsellik, yalnızca yaşamboyu PE'si olan bireylerin bir alt kümesinde mevcut olabilir veya yalnızca nöral seviyelerde veya belirli dürtüsellik alt tiplerinde belirgin olabilir.
References
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- 20. Joos L, Goudriaan AE, Schmaal L, Fransen E, Van Den Brink W, Sabbe BGC, et al. Effect of modafinil on impulsivity and relapse in alcohol dependent patients: a randomized, placebo-controlled trial. Eur Neuropsychopharmacol. 2013;23:948–55.
- 21. Schmaal L, Goudriaan AE, Joos L, Dom G, Pattij T, Van Den Brink W, et al. Neural substrates of impulsive decision making modulated by modafinil in alcohol-dependent patients. Psychol Med. 2014;44:2787–98.
- 22. Ayan ÜB, Ayhan MG. Lifelong Premature Ejaculation and Attention-Deficit Hyperactivity Disorder: A Controlled Study. Alpha Psychiatry. 2022;23:135–9.
- 23. Soydan H, Ates F, Adayener C, Akyol I, Semiz UB, Malkoc E, et al. Attention-deficit hyperactivity disorder in patients with premature ejaculation: a pilot study. Int Urol Nephrol. 2013;45:77–81.
- 24. Bijlenga D, Vroege JA, Stammen AJM, Breuk M, Boonstra AM, van der Rhee K, et al. Prevalence of sexual dysfunctions and other sexual disorders in adults with attention-deficit/hyperactivity disorder compared to the general population. Atten Defic Hyperact Disord. 2018;10:87–96.
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- 27. da Matta A, Gonçalves FL, Bizarro L. Delay discounting: Concepts and measures. Psychol Neurosci. 2012;5:135–46.
- 28. Moreira D, Barbosa F. Delay Discounting in Impulsive Behavior: A Systematic Review. Eur Psychol. 2019;24:312–21.
- 29. Altunoluk B, Baǧcioǧlu E, Efe E, Bahçeci B, Söylemez H. Temperament and Character Differences in Patients with Premature Ejaculation. Noro Psikiyatr Ars. 2013;50:332.
- 30. Garduño-Gutiérrez R, León-Olea M, Rodríguez-Manzo G. Different amounts of ejaculatory activity, a natural rewarding behavior, induce differential mu and delta opioid receptor internalization in the rat’s ventral tegmental area. Brain Res. 2013;1541:22–32.
- 31. Özdemir O. Is premature ejaculation an impulse control disorder? Med Hypotheses. 2012;79:59–62.
- 32. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.
- 33. Duke AA, Bègue L, Bell R, Eisenlohr-Moul T. Revisiting the serotonin-aggression relation in humans: a meta-analysis. Psychol Bull. 2013;139:1148–72.
- 34. Althof SE, Mcmahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, et al. An Update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). Sex Med. 2014;11:1392–422.
- 35. Zohdy W. Clinical Parameters that Predict Successful Outcome in Men with Premature Ejaculation and Inflammatory Prostatitis. J Sex Med. 2009;6:3139–46.
- 36. Barbonetti A, D’Andrea S, Cavallo F, Martorella A, Francavilla S, Francavilla F. Erectile Dysfunction and Premature Ejaculation in Homosexual and Heterosexual Men: A Systematic Review and Meta-Analysis of Comparative Studies. J Sex Med. 2019;16:624–32.
- 37. Pignatti R, Bertella L, Albani G, Mauro A, Molinari E, Semenza C. Decision-making in obesity: a study using the Gambling Task. Eat Weight Disord. 2006;11:126–32.
- 38. Navas JF, Vilar-López R, Perales JC, Steward T, Fernández-Aranda F, Verdejo-García A. Altered Decision-Making under Risk in Obesity. PLoS One. 2016;11: e0155600.
- 39. Wang C, Chan JSY, Ren L, Yan JH. Obesity Reduces Cognitive and Motor Functions across the Lifespan. Neural Plast. 2016;2016:2473081.
- 40. Salas-Venegas V, Flores-Torres RP, Rodríguez-Cortés YM, Rodríguez-Retana D, Ramírez-Carreto RJ, Concepción-Carrillo LE, et al. The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit. Front Integr Neurosci. 2022;16:798995.
- 41. Sari YE, Kokoglu B, Balcioglu H, Bilge U, Colak E, Unluoglu I. Turkish reliability of the patient health questionnaire-9. Biomedical Research. 2016;27:460–2.
- 42. Serefoglu EC, Cimen HI, Ozdemir AT, Symonds T, Berktas M, Balbay MD. Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. International Journal of Impotence Research 2009;21:139–44.
- 43. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49:822–30.
- 44. Güleç H, Tamam L, Güleç MY, Turhan M, Karakufl G, Zengin M, et al. Psychometric Properties of the Turkish Version of the Barratt Impulsiveness Scale-11. Psychiatry and Clinical Psychopharmacology. 2008;18:251–8.
- 45. Lejuez CW, Read JP, Kahler CW, Richards JB, Ramsey SE, Stuart GL, et al. Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task (BART). J Exp Psychol Appl. 2002;8:75–84.
- 46. Kocalevent RD, Hinz A, Brähler E. Standardization of the depression screener patient health questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry. 2013;35:551–5.
- 47. Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, et al. Development and validation of a premature ejaculation diagnostic tool. Eur Urol. 2007;52:565–73.
- 48. Daker-White G. Reliable and valid self-report outcome measures in sexual (dys)function: a systematic review. Arch Sex Behav. 2002; 31:197–209.
- 49. Hunt MK, Hopko DR, Bare R, Lejuez CW, Robinson E V. Construct Validity of the Balloon Analog Risk Task (BART). Assessment. 2016;12:416–28.
- 50. Lejuez CW, Aklin WM, Bornovalova MA, Moolchan ET. Differences in Risk-Taking Propensity Across Inner-City Adolescent Ever- and Never-Smokers. Nicotine & Tobacco Research. 2005;7:71–9.
- 51. Whiteside SP, Lynam DR, Miller JD, Reynolds SK. Validation of the UPPS impulsive behaviour scale: a four-factor model of impulsivity. Eur J Pers. 2005;19:559–74.
- 52. Tomko RL, Solhan MB, Carpenter RW, Brown WC, Jahng S, Wood PK, et al. Measuring Impulsivity in Daily Life: The Momentary Impulsivity Scale. Psychol Assess. 2014;26:339–49.
- 53. Johnson MW, Bruner NR. The Sexual Discounting Task: HIV Risk Behavior and the Discounting of Delayed Sexual Rewards in Cocaine Dependence. Drug Alcohol Depend. 2012;123(1–3):15–21.
- 54. Kalapatapu RK, Lewis DF, Vinogradov S, Batki SL, Winhusen T. Relationship of Age to Impulsivity and Decision-Making: A Baseline Secondary Analysis of a Behavioral Treatment Study in Stimulant Use Disorders. J Addict Dis. 2013;32:206–16.
- 55. Ziada KE, Becker D, Farah Bakhiet S, Dutton E, Ahmed Sayed Essa Y. Impulsivity among young adults: Differences between and within Western and Arabian populations in the BIS-11. Current Psychology. 2020;39:464–73.
Evaluation of risky decision-making and impulsivity in individuals with premature ejaculation
Year 2023,
, 422 - 428, 20.10.2023
Serkan Aksu
,
Harun Bal
,
İlker Akarken
,
Hasan Deliktaş
,
Hayrettin Şahin
Abstract
Objective
Different mechanisms such as psychological, neurobiological, autonomic, and genetic factors might be involved in the etiology of lifelong Premature Ejaculation (PE). Albeit cortical activity changes have been reported, the relationship between PE and impulsivity/decision-making is minimally studied to date. The present study aimed to assess impulsivity and risky decision-making in individuals with lifelong PE for the first time.
Method
26 lifelong PE patients were diagnosed by the International Society for Sexual Medicine (ISSM-2014) criteria and 26 healthy volunteers were recruited. The Premature Ejaculation Diagnostic Tool (PEDT), International Erectile Function Index (IIEF), Barratt Impulsiveness Scale-11 (BIS-11), Patient Health Questionnaire-9 (PHQ-9), Balloon Analogue Risk Task (BART), and Monetary Choice Questionnaire-27 (MCQ-27) were administered.
Results
The mean age was 37.28 (18-55). No differences were found between groups in risky decision-making and impulsivity.
Conclusion
No alterations of impulsivity and risky decision-making were found in lifelong PE patients. Impulsivity may only exist in a subset of individuals with lifelong PE or may only be evident in neural levels or specific subtypes of impulsivity.
References
- 1. Ciocanel O, Power K, Eriksen A. Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews. Sex Med. 2019;7:251–69.
- 2. Waldinger MD. The pathophysiology of lifelong premature ejaculation. Transl Androl Urol. 2016;5:424–33.
- 3. Silva H, Iturra P, Solari A, Villarroel J, Jerez S, Jiménez M, et al. Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder. Psychiatr Genet. 2010;20:25–30.
- 4. Butler T, Schofield PW, Knight L, Ton B, Greenberg D, Scott RJ, et al. Sertraline hydrochloride for reducing impulsive behaviour in male, repeat-violent offenders (ReINVEST): protocol for a phase IV, double-blind, placebo-controlled, randomised clinical trial. BMJ Open. 2021;11: e044656.
- 5. New AS, Buchsbaum MS, Hazlett EA, Goodman M, Koenigsberg HW, Lo J, et al. Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression. Psychopharmacology (Berl). 2004;176(3–4):451–8.
- 6. Kawashima T. The role of the serotonergic system in motor control. Neurosci Res. 2018;129:32–9.
- 7. Evenden J. Impulsivity: a discussion of clinical and experimental findings. J Psychopharmacol. 1999;13:180–92.
- 8. Puig MV, Gulledge AT. Serotonin and prefrontal cortex function: neurons, networks, and circuits. Mol Neurobiol. 2011;44:449–64.
- 9. Mavrogiorgou P, Enzi B, Klimm AK, Köhler E, Roser P, Norra C, et al. Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivity. Hum Brain Mapp. 2017;38:1507–17.
- 10. Skandali N, Rowe JB, Voon V, Deakin JB, Cardinal RN, Cormack F, et al. Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans. Neuropsychopharmacology 2018;43:2645–51.
- 11. Crockett MJ, Clark L, Robbins TW. Reconciling the Role of Serotonin in Behavioral Inhibition and Aversion: Acute Tryptophan Depletion Abolishes Punishment-Induced Inhibition in Humans. The Journal of Neuroscience. 2009;29:11993.
- 12. Kim S, Lee D. Prefrontal cortex and impulsive decision making. Biol Psychiatry. 2011;69:1140–6.
- 13. Wallis JD. Orbitofrontal cortex and its contribution to decision-making. Annu Rev Neurosci. 2007;30:31–56.
- 14. Rosenbloom MH, Schmahmann JD, Price BH. The functional neuroanatomy of decision-making. J Neuropsychiatry Clin Neurosci. 2012;24:266–77.
- 15. Ludwig VU, Nüsser C, Goschke T, Wittfoth-Schardt D, Wiers CE, Erk S, et al. Delay discounting without decision-making: Medial prefrontal cortex and amygdala activations reflect immediacy processing and correlate with impulsivity and anxious-depressive traits. Front Behav Neurosci. 2015;9:280.
- 16. Peters J. The Role of the Medial Orbitofrontal Cortex in Intertemporal Choice: Prospection or Valuation? Journal of Neuroscience. 2011;31:5889–90.
- 17. Yang X, Gao M, Zhang L, Liu L, Liu P, Sun J, et al. Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients. Front Hum Neurosci. 2018;12:206.
- 18. Haghighi M, Jahangard L, Meybodi AM, Shayganfard M, Ahmadpanah M, Faryadres M, et al. Influence of modafinil on early ejaculation – Results from a double-blind randomized clinical trial. J Psychiatr Res. 2022;146:264–71.
- 19. Gomez-Ordoñez D, Juárez J. Differential effect of modafinil on impulsivity, attention and motor activity in preadolescent rats prenatally treated with alcohol. Brain Res. 2019;1722:146395.
- 20. Joos L, Goudriaan AE, Schmaal L, Fransen E, Van Den Brink W, Sabbe BGC, et al. Effect of modafinil on impulsivity and relapse in alcohol dependent patients: a randomized, placebo-controlled trial. Eur Neuropsychopharmacol. 2013;23:948–55.
- 21. Schmaal L, Goudriaan AE, Joos L, Dom G, Pattij T, Van Den Brink W, et al. Neural substrates of impulsive decision making modulated by modafinil in alcohol-dependent patients. Psychol Med. 2014;44:2787–98.
- 22. Ayan ÜB, Ayhan MG. Lifelong Premature Ejaculation and Attention-Deficit Hyperactivity Disorder: A Controlled Study. Alpha Psychiatry. 2022;23:135–9.
- 23. Soydan H, Ates F, Adayener C, Akyol I, Semiz UB, Malkoc E, et al. Attention-deficit hyperactivity disorder in patients with premature ejaculation: a pilot study. Int Urol Nephrol. 2013;45:77–81.
- 24. Bijlenga D, Vroege JA, Stammen AJM, Breuk M, Boonstra AM, van der Rhee K, et al. Prevalence of sexual dysfunctions and other sexual disorders in adults with attention-deficit/hyperactivity disorder compared to the general population. Atten Defic Hyperact Disord. 2018;10:87–96.
- 25. Ainslie G. Specious reward: a behavioral theory of impulsiveness and impulse control. Psychol Bull. 1975;82:463–96.
- 26. Kaplan BA, Amlung M, Reed DD, Jarmolowicz DP, McKerchar TL, Lemley SM. Automating Scoring of Delay Discounting for the 21- and 27-Item Monetary Choice Questionnaires. Behavior Analyst. 2016;39:293–304.
- 27. da Matta A, Gonçalves FL, Bizarro L. Delay discounting: Concepts and measures. Psychol Neurosci. 2012;5:135–46.
- 28. Moreira D, Barbosa F. Delay Discounting in Impulsive Behavior: A Systematic Review. Eur Psychol. 2019;24:312–21.
- 29. Altunoluk B, Baǧcioǧlu E, Efe E, Bahçeci B, Söylemez H. Temperament and Character Differences in Patients with Premature Ejaculation. Noro Psikiyatr Ars. 2013;50:332.
- 30. Garduño-Gutiérrez R, León-Olea M, Rodríguez-Manzo G. Different amounts of ejaculatory activity, a natural rewarding behavior, induce differential mu and delta opioid receptor internalization in the rat’s ventral tegmental area. Brain Res. 2013;1541:22–32.
- 31. Özdemir O. Is premature ejaculation an impulse control disorder? Med Hypotheses. 2012;79:59–62.
- 32. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.
- 33. Duke AA, Bègue L, Bell R, Eisenlohr-Moul T. Revisiting the serotonin-aggression relation in humans: a meta-analysis. Psychol Bull. 2013;139:1148–72.
- 34. Althof SE, Mcmahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, et al. An Update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). Sex Med. 2014;11:1392–422.
- 35. Zohdy W. Clinical Parameters that Predict Successful Outcome in Men with Premature Ejaculation and Inflammatory Prostatitis. J Sex Med. 2009;6:3139–46.
- 36. Barbonetti A, D’Andrea S, Cavallo F, Martorella A, Francavilla S, Francavilla F. Erectile Dysfunction and Premature Ejaculation in Homosexual and Heterosexual Men: A Systematic Review and Meta-Analysis of Comparative Studies. J Sex Med. 2019;16:624–32.
- 37. Pignatti R, Bertella L, Albani G, Mauro A, Molinari E, Semenza C. Decision-making in obesity: a study using the Gambling Task. Eat Weight Disord. 2006;11:126–32.
- 38. Navas JF, Vilar-López R, Perales JC, Steward T, Fernández-Aranda F, Verdejo-García A. Altered Decision-Making under Risk in Obesity. PLoS One. 2016;11: e0155600.
- 39. Wang C, Chan JSY, Ren L, Yan JH. Obesity Reduces Cognitive and Motor Functions across the Lifespan. Neural Plast. 2016;2016:2473081.
- 40. Salas-Venegas V, Flores-Torres RP, Rodríguez-Cortés YM, Rodríguez-Retana D, Ramírez-Carreto RJ, Concepción-Carrillo LE, et al. The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit. Front Integr Neurosci. 2022;16:798995.
- 41. Sari YE, Kokoglu B, Balcioglu H, Bilge U, Colak E, Unluoglu I. Turkish reliability of the patient health questionnaire-9. Biomedical Research. 2016;27:460–2.
- 42. Serefoglu EC, Cimen HI, Ozdemir AT, Symonds T, Berktas M, Balbay MD. Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. International Journal of Impotence Research 2009;21:139–44.
- 43. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49:822–30.
- 44. Güleç H, Tamam L, Güleç MY, Turhan M, Karakufl G, Zengin M, et al. Psychometric Properties of the Turkish Version of the Barratt Impulsiveness Scale-11. Psychiatry and Clinical Psychopharmacology. 2008;18:251–8.
- 45. Lejuez CW, Read JP, Kahler CW, Richards JB, Ramsey SE, Stuart GL, et al. Evaluation of a behavioral measure of risk taking: the Balloon Analogue Risk Task (BART). J Exp Psychol Appl. 2002;8:75–84.
- 46. Kocalevent RD, Hinz A, Brähler E. Standardization of the depression screener patient health questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry. 2013;35:551–5.
- 47. Symonds T, Perelman MA, Althof S, Giuliano F, Martin M, May K, et al. Development and validation of a premature ejaculation diagnostic tool. Eur Urol. 2007;52:565–73.
- 48. Daker-White G. Reliable and valid self-report outcome measures in sexual (dys)function: a systematic review. Arch Sex Behav. 2002; 31:197–209.
- 49. Hunt MK, Hopko DR, Bare R, Lejuez CW, Robinson E V. Construct Validity of the Balloon Analog Risk Task (BART). Assessment. 2016;12:416–28.
- 50. Lejuez CW, Aklin WM, Bornovalova MA, Moolchan ET. Differences in Risk-Taking Propensity Across Inner-City Adolescent Ever- and Never-Smokers. Nicotine & Tobacco Research. 2005;7:71–9.
- 51. Whiteside SP, Lynam DR, Miller JD, Reynolds SK. Validation of the UPPS impulsive behaviour scale: a four-factor model of impulsivity. Eur J Pers. 2005;19:559–74.
- 52. Tomko RL, Solhan MB, Carpenter RW, Brown WC, Jahng S, Wood PK, et al. Measuring Impulsivity in Daily Life: The Momentary Impulsivity Scale. Psychol Assess. 2014;26:339–49.
- 53. Johnson MW, Bruner NR. The Sexual Discounting Task: HIV Risk Behavior and the Discounting of Delayed Sexual Rewards in Cocaine Dependence. Drug Alcohol Depend. 2012;123(1–3):15–21.
- 54. Kalapatapu RK, Lewis DF, Vinogradov S, Batki SL, Winhusen T. Relationship of Age to Impulsivity and Decision-Making: A Baseline Secondary Analysis of a Behavioral Treatment Study in Stimulant Use Disorders. J Addict Dis. 2013;32:206–16.
- 55. Ziada KE, Becker D, Farah Bakhiet S, Dutton E, Ahmed Sayed Essa Y. Impulsivity among young adults: Differences between and within Western and Arabian populations in the BIS-11. Current Psychology. 2020;39:464–73.