The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication

Year 2017, , 196 - 201, 22.09.2017

Mucahit Gunaydin , Suha Turkmen Yunus Karaca , Ozgur Tatli , Furkan Yildirim Buket Akcan Altinkaynak Abdulkadir Gunduz

https://doi.org/10.18521/ktd.331426

Abstract

Objective: Carbon monoxide (CO) is the main cause of
intoxication-related mortality and morbidity in developed countries. It is
responsible for more than half of fatal intoxications in many countries. The purpose of this study
was to determine the diagnostic value of protein carbonyl (PC), a good marker
of oxidative stress, in association with oxidative stress resulting from
hypoxia emerging in patients with acute CO intoxication.

Methods: Thirty-four patients diagnosed with acute
CO intoxication at the Emergency Department and 38 healthy volunteers were
included in the study. Patients’ PC levels at time of admission and after
treatment were compared with those of a control group.

Results: No statistically significant difference
was observed among PC levels at time of admission in the patient and control
groups (p =0.305, patient
group 0.025 ± 0.01, control group 0.026 ±
0.01). A significant decrease was determined in post-treatment PC levels in the
patient group compared to those at time of admission (p
= 0.006, admission 0.025 ± 0.01,
post-treatment 0.017 ± 0.008). No significant correlation was determined
between patients’ carboxyhemoglobin (CO-Hb) levels and PC levels at time of
admission (Correlation coefficient = -0.006, p= 0.971).

Conclusion: We think that PC is not suitable for use as
a biomarker in the acute period in patients with CO intoxication.

Keywords

Carbon monoxide poisoning, Oxidative stress, Protein carbonyl

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