An Experimental Study on the Effectiveness of Hyperbaric Oxygen and Thymoquinone Treatment in Blunt Duedonal Injury

Abstract

Objective: In duodenum injuries, despite being in a well-preserved area of abdomen, the duodenum is injured due to the presence of behind structures and good fixation lumbar vertebrae. HBO2 treatment reduces ischemia, one of the major causes of secondary damage. HBO2 treatment given serially after trauma, provide clinical, histopathological and biochemical recovery. Thymoquinone(TQ) has been shown to accelerate wound healing in topical or systemic use. We think that Grade 1-2 blunt duodenal traumas will benefit from HBO2 and oral TQ treatment.

Methods: 32 Wistar Albino rats were randomly assigned 4 groups. Surgical procedures were applied to rats outside Sham group. The first group was selected as sham, the second group was control, the third group was HBO2 treatment and the fourth group was HBO2 + TQ treatment. The results were examined histo-pathologically and biochemically in duodenum and serum.

Results: Therapy added TQ therapy increased the healing success while HBO2 treatment accelerated healing in histo-pathological findings. Although the parameters studied in the duodenum and serum were partially parallel to histo-pathologic changes, biochemical values were not found statistically significant in generally.

Conclusion: In this study, blunt trauma damage was simulated in the 2nd part of the duodenum. HBO2 and TQ treatment improved healing compared to the other groups in Grade 1-2 injuries. We believe that patients with Grade 1 and 2 duodenal injuries, if a successful HBO2 program and a treatment with TQ is added to the conservative therapy will benefit better than the existing treatment methods.

Keywords

• hyperbaric oxygenation,thymoquinone,blunts injuries,surgical traumatology,Recovery of Function

Deneysel Künt Duodenum Yaralanmalarında Hiperbarik Oksijen Tedavisi ve Timokinon’un Etkisi

Abstract

Amaç: Duodenumun abdomenin iyi korunmuş bir alanında olmasına rağmen, duodenum arkasında lomber vertebralar bulunmasından ve iyi fikse olmasından dolayı özellikle künt travmalarda yaralanabilmektedir. Hiperbarik Oksijen (HBO2) tedavisi, sekonder hasarın en önemli nedenlerinden biri olan iskemiyi azaltır. Travmadan sonra seri olarak verilen HBO2 tedavileri klinik, histopatolojik ve biyokimyasal fayda sağlar. Timokinon’un (TQ) topikal veya sistemik kullanımda yara iyileşmesini hızlandırdığı gösterilmiştir. Çalışmamızda deneysel oluşturulmuş Grade 1-2 künt duodenal travmalarda HBO2 ve oral TQ tedavisinin yararlı olabileceği yönünde sonuçlar elde edilmiştir.

Gereç ve Yöntem: 32 adet Wistar Albino cinsi rat rastgele 4 gruba ayıldı. Birinci grup dışındaki ratlara cerrahi işlem uygulanmıştır. İlk grup sham olarak seçilirken 2. grup kontrol, 3. grup HBO2 tedavisi, 4. grup ise HBO2+TQ tedavisi almıştır. Sonuçlar duodenum ve serumda histopatolojik ve biyokimyasal olarak incelenmiştir.

Bulgular: Histopatolojik bulgularda HBO2 tedavisi iyileşmeyi hızlandırırken tedaviye eklenen TQ tedavisi iyileşmedeki başarıyı artırmıştır. Duodenum dokusunda ve serumda çalışılan parametreler histopatolojik değişikliklere kısmen paralel olsa bile biyokimyasal değerler genel olarak istatistiksel olarak anlamlı bulunmamıştır.

Sonuç:  Bu çalışmada duodenumun 2. kısmına künt hasar taklit edilmiş ve HBO2 ve TQ tedavisinin Grade 1-2 hasarlarda diğer gruplara göre iyileşme sağladığı gösterilmiştir. Grade 1 ve 2 duodenal hasarlarda, konservatif tedavinin yanında belirlenecek bir HBO2 programı ve bu programa TQ eklenerek tedavide başarılı yanıtlar alınabileceğini düşünüyoruz.

Keywords

• hiperbarik oksijenasyon,timokinon,künt yaralanmalar,cerrahi travmatoloji,Cerrahi Travmatoloji,fonksiyonun geri kazanılması

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