TEKRARLAYAN DÜŞÜK VE TAM KAN SAYIMI DEĞERLERİ ARASINDA HERHANGİ BİR İLİŞKİ VAR MI? BİR VAKA-KONTROL ÇALIŞMASI

Abstract

AMAÇ:Tam kan sayımı değerleri ile tekrarlayan düşük arasındaki ilişkinin incelenmesi amaçlanmıştır.

GEREÇ VE YÖNTEM:2010-2018 yılları arasında tekrarlayan düşük yapan hastalarda vaka-kontrol çalışması yaptık. Vaka grubunda dahil edilme kriterlerini karşılayan 50 hastanın verilerini, 60 kadından oluşan, en az bir canlı doğum yapmış aynı yaş grubundan kontrol grubu ile eşleştirdik. Tam kan sayımında kırmızı kan hücresi (RBC), hemoglobin (HB), hematokrit (HTC), ortalama korpüsküler hacim (MCV), ortalama korpüsküler hemoglobin (MCH), ortalama korpüsküler hemoglobin konsantrasyonu (MCHC), trombosit sayısı (PLT), trombosit dağılım genişliği (PDW), kan sayımında ortalama trombosit hacmi (MPV), kırmızı hücre dağılım genişliği (RDW) ve plateletkreit hesaplaması (PCT) incelendi. İstatistiksel analiz için SPSS 20.0.0 yazılımı kullanıldı. P<0,05 değeri istatistiksel olarak anlamlı kabul edildi.

BULGULAR: Katılımcıların yaş ortalaması 29,08±5,5 yıldı. Vaka grubunda MPV ve RDW değerleri ile PCT hesaplaması sağlıklı kontrol grubundan anlamlı olarak yüksek bulundu (p<0,05). Vaka grubunun MCHC düzeyleri kontrol grubundan düşüktü (p<0,05). Vaka ve kontrol grubu arasında RBC, HB, HCT, MCV, MCH, PLT ve PDW açısından anlamlı bir fark yoktu (p>0,05).

SONUÇLAR:Yüksek MPV, RDW, PCT ve düşük MCHC gibi tam kan sayımı parametreleri, tekrarlayan düşüklerin önemli bir belirleyicisi olarak düşünülebilir. Bulgularımız, bu kan hücresi fonksiyon belirteçleri ve tekrarlayan düşükler arasındaki ilişkiyi netleştirmek için daha fazla sayıda hasta içeren ileriye dönük çalışmalar ile desteklenmelidir.

Keywords

• ortalama trombosit hacmi,tekrarlayan düşük

Is There Any Relation Between Recurrent Miscarriage and Complete Blood Count Values? A Case-Control Study

Abstract

Objective: It was aimed to examine the relationship of complete blood count values with recurrent miscarriage.

Method: We carried out a case-control study of patients who had recurrent miscarriage between 2010-2018. Data were collected from 50 patients who were meeting the case group inclusion criteria, and age-matched healthy control group with at least one live birth who consisted of 60 women. Red blood cell (RBC), hemoglobin (HB), hematocrit (HTC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW) and plateletcrit count (PCT) were examined by complete blood count. SPSS 20.0.0 software was used for statistical analysis. P values <0.05 were regarded as statistically significant.

Results: The mean age of the case group was 29.8±5.8 years, and the mean age of the control group was 28.7±5.2 years (p>0,05). MPV and RDW values and PCT calculations were significantly higher than healthy control group (p<0.05). MCHC levels of case group were lower than control group (p<0.05). There were no significant differences between the case and control groups in terms of RBC, HB, HCT, MCV, MCH, PLT, and PDW (p>0.05).

Conclusion: Complete blood count parameters such as high MPV, RDW, PCT, and low MCHC could be considered as an important predictor of recurrent miscarriage. Our findings should be supported by further prospective studies involving a larger number of patients in order to clarify the relationship between these blood cell function markers and recurrent miscarriage.

Keywords

• mean platelet volume,recurrent miscarriage

References

1. 1. Cunningham F, Leveno K, Bloom S, Hauth G, Spong C, Dwight J. Text book of Williams' obstetrics-Hypertensive disorder inpregnancy. Text book of Williams' obstetrics-Hypertensive disorder inpregnancy. New York: McGraw-Hill; 2010. p. 292p.
2. 2. Laird SM, Tuckerman EM, Cork BA, Linjawi S, Blakemore AI, Li TC. A review of immune cells and molecules in women with recurrent miscarriage. Hum Reprod Update. 2003;9(2):163-74.
3. 3. Di Nisio M, Peters L, Middeldorp S. Anticoagulants for the treatment of recurrent pregnancy loss in women without antiphospholipid syndrome. Cochrane Database Syst Rev. 2005(2):CD004734.
4. 4. Van Dreden P, Woodhams B, Rousseau A, Favier M, Favier R. Comparative evaluation of Tissue factor and Thrombomodulin activity changes during normal and idiopathic early and late foetal loss: the cause of hypercoagulability? Thromb Res. 2012;129(6):787-92.
5. 5. Kosus N, Kosus A, Yildirim M, Duran M, Turhan NO. Mean platelet volume as a marker of thrombosis in patients with missed abortion. Acta Haematol. 2011;125(4):208-9.
6. 6. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28-32.
7. 7. Tygart SG, McRoyan DK, Spinnato JA, McRoyan CJ, Kitay DZ. Longitudinal study of platelet indices during normal pregnancy. Am J Obstet Gynecol. 1986;154(4):883-7.
8. 8. Uskul H, Kilicaslan O, Yildirmak ZY, Ozsan H. Evaluation of Blood Parameters in Attention Deficiency and Hyperactivity Disorder. Konuralp Tip Derg. 2017;9(3):207-12.

9. 9. Singh A, Varma R. Role of Platelet Distribution Width (PDW) and Plateletcrit in the Assessment of Nonthrombocytopenic Preeclampsia and Eclampsia. J Obstet Gynaecol India. 2018;68(4):289-93.
10. 10. Shahine L, Lathi R. Recurrent pregnancy loss: evaluation and treatment. Obstet Gynecol Clin North Am. 2015;42(1):117-34.
11. 11. Lee SK, Na BJ, Kim JY, Hur SE, Lee M, Gilman-Sachs A, et al. Determination of clinical cellular immune markers in women with recurrent pregnancy loss. Am J Reprod Immunol. 2013;70(5):398-411.
12. 12. Ege MR, Acikgoz S, Zorlu A, Sincer I, Guray Y, Guray U, et al. Mean platelet volume: an important predictor of coronary collateral development. Platelets. 2013;24(3):200-4.
13. 13. Acikgoz S, Ege MR, Guray U. Relationship between the elevated mean platelet volume and coronary microvascular function in patients with idiopathic dilated cardiomyopathy. Platelets. 2013;24(2):162-3.
14. 14. Temur I, Kucukgoz Gulec U, Paydas S, Guzel AB, Sucu M, Vardar MA. Prognostic value of pre-operative neutrophil/lymphocyte ratio, monocyte count, mean platelet volume, and platelet/lymphocyte ratio in endometrial cancer. Eur J Obstet Gynecol Reprod Biol. 2018;226:25-9.
15. 15. Lin WY, Lu X, Fan FJ, Hu Y. Predictive Effect of Mean Platelet Volume in Patients with Portal Vein Thrombosis: A Meta-analysis of Case-control Studies. Curr Med Sci. 2018;38(4):575-81.
16. 16. Vilchez G, Lagos M, Kumar K, Argoti P. Is mean platelet volume a better biomarker in pre-eclampsia? J Obstet Gynaecol Res. 2017;43(6):982-90.
17. 17. AlSheeha MA, Alaboudi RS, Alghasham MA, Iqbal J, Adam I. Platelet count and platelet indices in women with preeclampsia. Vasc Health Risk Manag. 2016;12:477-80.
18. 18. Cardinale C, Berbis J, Chau C, Bernard F, Arnoux D, Fratacci MF, et al. Two miscarriages, consecutive or non-consecutive, does it change something? J Gynecol Obstet Hum Reprod. 2017;46(10):721-5.
19. 19. Bocutoglu AC, Gumral N, Mungan MT. Comparison of platelet functions in the evaluation of hematological parameters in pregnant women. SDÜ Sağlık Bilimleri Enstitüsü Dergisi 2010;1(2):88-94.
20. 20. Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, et al. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets. 2010;21(2):122-5.
21. 21. Huang YL, Hu ZD. Lower mean corpuscular hemoglobin concentration is associated with poorer outcomes in intensive care unit admitted patients with acute myocardial infarction. Ann Transl Med. 2016;4(10):190.
22. 22. Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Arch Intern Med. 2009;169(6):588-94.
23. 23. Dundar O, Pektas MK, Bodur S, Bakir LV, Cetin A. Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width. J Obstet Gynaecol Res. 2015;41(4):551-8.
24. 24. Ural UM, Tekin YB, Balik G, Sahin FK, Colak S. Could platelet distribution width be a predictive marker for unexplained recurrent miscarriage? Arch Gynecol Obstet. 2014;290(2):233-6.
25. 25. Thompson CB. From precursor to product: how do megakaryocytes produce platelets? Prog Clin Biol Res. 1986;215:361-71.
26. 26. Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2014;175:107-11.