Diagnostic Comparison Of Troponin and Scube 1 Levels In Patients Diagnosed with Stemi and Nstemi In The Emergency Department

Abstract

Objective: In the present study we aimed to compare the levels of troponin and SCUBE1 markers to determine the diagnostic role of SCUBE1 in patients with STEMI-NSTEMI. Method: This study was prospectively conducted with 119 patients diagnosed with acute myocardial infarction at the emergency department and 30 control subjects between 01.10.2016 and 01.02.2017. The relationship between age, sex, acute myocardial infarction (AMI)type, white blood cell(WBC), lymphocyte, neutrophil, neutrophil/lymphocyte ratio, red cell distribution width(RDW), thrombocyte count, aspartate aminotransferase(AST), alanine aminotransferase(ALT), CK, CK-MB, troponin, and SCUBE 1 level was examined. Age, sex, and SCUBE 1 level were compared between the patient and control groups. Results: The patients had a mean age of 61.5±14.5 years, and 68.9% of them were male. The patients had a SCUBE 1 level of 79.7 ng/mL and the control group 53.2 ng/ml.SCUBE1 level was comparable between the patients with acute myocardial infarction and the control group. A correlation was found between the SCUBE1 level and age. Women in the patient group had a significantly higher SCUBE1 level. There was a positive correlation between the WBC, CKMB, and troponin levels, and SCUBE 1 level in the patient group. No correlation was found between SCUBE 1 level and neutrophil, lymphocyte, neutrophil/lymphocyte ratio, RDW, platelet, AST, ALT, and CK levels. There was no significant correlation between infarction type and SCUBE 1 level. Conclusion: SCUBE1 level did not significantly rise in patients with acute myocardial infarction. As the test had lower sensitivity and specificity compared to the other markers, we believe that it is not suitable for practical use.

Keywords

• SCUBE 1
• acute myocardial infarction
• Troponin

Acil Serviste Tanı Alan Stmı ve Nstmı Hastalarda Troponin Değerleri ve Scube 1 Değerlerinin Tanısal Karşılaştırılması

Abstract

Amaç: Bu çalışmada ST elevasyonlu miyokard ifarktüsü (STEMI) ve ST elevasyonu olmayan miyokard ifarktüsü (NSTEMI) hastalarında troponin ve serum signal peptide-CUB-EGF domain-containing protein 1 (SCUBE 1) markerlarını karşılaştırıp erken tanıdaki SCUBE 1 değerinin tanısal önemini saptamayı amaçladık. Gereç ve Yöntem: Çalışma 01.10.2016 ve 01.02.2017 tarihleri arasında Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi acil servisinde, akut miyokard infaktüsü tanısı konan 119 hasta ve 30 kontrol grubu ile prospektif olarak gerçekleştirildi. Hastaların yaş, cinsiyet, white blood cell (WBC), nötrofil, lenfosit, nötrofil/lenfosit, red cell distribution width (RDW), trombosit, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK) , CK-MB, troponin ve AMİ alt tipinin SCUBE 1 düzeyleri olan ilişkisi incelendi. Veriler SPSS Windows 22 versiyonunda analiz edildi. Bulgular: Hastaların yaş ortalaması 61,5±14,5 yıl olup, %68,9’u erkekti. Hastaların SCUBE 1 düzeyi 79,7ng/mL, kontrol grubunun SCUBE 1 düzeyi 63,2 ng/ml olarak saptandı. AMI’li hastalar ve kontrol grubu arasında SCUBE 1 düzeyi benzerdi (p>0,05). SCUBE 1 düzeyi ve yaş arasında korelasyon saptanmadı (p>0,05). Hasta gruptaki kadınlarda SCUBE 1 düzeyi anlamlı olarak yüksekti (p<0,05).Hastalarda WBC, CK-MB ve troponin düzeyleri SCUBE 1 arasında pozitif yönlü korelasyon saptandı. Nötrofil, lenfosit, nötrofil/lenfosit oranı RDW, platelet, AST, ALT ve CK düzeylerinin SCUBE 1 ile arasında korelasyon saptanmadı (p>0,05). İnfaktüs tipi ve SCUBE 1 düzeyi arasında ilişki saptanmadı (p>0,05). Sonuç: AMI’li hastalarda SCUBE 1 düzeyindeki artış anlamlı değildi. Testin spesifitesi ve sensitivitesinin diğer markerlara göre düşük olması sebebiyle, pratik kullanım için yetersiz olduğu kanısı doğmaktadır.

Keywords

• SCUBE 1
• Akut miyokard infarktüsü
• Troponin

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