Ailesel Akdeniz Ateşi Olan Hastalarda Nazal Mukosiliyer Aktivitenin Değerlendirilmesi

Abstract

Amaç: Bu çalışmanın amacı Ailesel Akdeniz Ateşi (AAA) hastalarında anterior rinomanometre ve sakarin test kullanılarak nazal hava yolu direncini ve nazal mukosiliyer aktiviteyi değerlendirmektir.

Gereç ve Yöntem: Bu prospektif, kesitsel çalışmaya AAA hastalığı olan 30 hasta ve 30 sağlıklı birey dahil edildi. Tüm katılımcılara nazal hava yolu direncini ölçmek için aktif anterior rinomanometre ve nazal mukosiliyer klerens zamanını ölçmek için sakarin test uygulandı.

Bulgular: AAA hasta grubu ve kontrol gruplarında ortalama nazal mukosiliyer klerens zamanı sırasıyla 14.6 ± 4.7 (aralık, 8-30) dk. ve 9,7 ± 2,3 (aralık, 6-14) dk. olarak saptandı. AAA hastalarında nazal mukosiliyer klerens zamanı sağlıklı kontrollere göre anlamlı olarak uzundu ( p <0.001). Nazal mukosiliyer klerens zamanı ile hastalık süresi arasında istatistiksel olarak anlamlı bir korelasyon tespit etmedik ( p <0.001, r=0.019). Her iki grubun ortalama nazal hava yolu direnci değerleri karşılaştırıldığında, anlamlı bir fark saptanmadı (p=0.371).

Sonuç: Çalışmamızın sonuçları, AAA hastalarında nazal mukosiliyer klerens zamanının sağlıklı kontrollere göre daha uzun olduğunu ortaya koymuştur. Bununla birlikte, nazal mukosiliyer klerens süresi ve hastalık süresi arasında istatistiksel olarak anlamlı bir korelasyon yoktu. Nazal mukosiliyer klerensin bozulması, üst ve alt solunum yollarında enfeksiyon riskini artırır. AAA hastalarında üst ve alt solunum yolu enfeksiyonlarına karşı dikkatli olunmalıdır.

Keywords

• Ailesel Akdeniz Ateşi
• Mukosiliyer temizlik
• Rinomanometre

Evaluation of Nasal Mucociliary Activity in Patients with Familial Mediterranean Fever

Abstract

Objective: The aim of this study was to evaluate nasal airway resistance and nasal mucociliary activity in Familial Mediterranean Fever (FMF) patients using anterior rhinomanometry and saccharin clearance test.

Methods: 30 patients with FMF disease and 30 healthy individuals were included in this prospective, cross-sectional study. Nasal airway resistance was measured via active anterior rhinomanometry and a saccharin test was carried out for the measurement of nasal mucociliary clearance (NMC) times of all participants.

Results: Mean values for NMC time in the FMF patient group and control group were found as 14.6 ± 4.7 (range, 8-30) min. and 9.7 ± 2.3 (range, 6-14) min. respectively. Nasal mucociliary clearance time in the FMF patients was significantly prolonged in comparison to that of healthy controls (p < 0.001). We identified no significant correlation between the disease duration and NMC time (p=0.921, r = 0.019). When the mean nasal airway resistance values of both groups were compared, there was no significant difference was detected (p = 0.371).

Conclusion: The results of our study have revealed that NMC time was longer in patients with FMF than healthy controls. However, there was no statistically significant correlation between nasal mucociliary clearance time and disease duration. Disruption of NMC increases the risk of infection in the upper and lower respiratory tract. Caution should be exercised against upper and lower respiratory infections in patients with FMF.

Keywords

• Familial Mediterranean Fever
• Mucociliary clearance
• Rhinomanometry

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