The Relationship Between Hyperplastic Gastric Polyps And Helicobacter Pylori

Abstract

Objective Helicobacter pylori (H. pylori) is a gram-negative bacterium. It is urease positive, mobile, microaerophilic, and spiral-shaped, and it settles in the stomach and the proximal duodenum. It is associated with chronic gastritis, stomach ulcers, duodenal ulcers, stomach cancer, and MALT lymphoma. It can also cause premalignant lesions, such as metaplasia and gastric atrophy. Although several studies are investigating the correlation between H. pylori and hyperplastic polyps (HPs) of the stomach, uncertainty in this regard continues. Methods Data from 5378 patients who underwent esophagogastroduodenoscopy at the Department of Gastroenterology, Gülhane Training and Research Hospital, University Of Health Sciences between October 2016 and March 2019 were retrospectively analyzed, and patients with gastric polyps were evaluated for polyp pathologies and normal mucosa biopsies. Results Sixty-one stomach polyps were detected in 49 patients after the retrospective analysis of the data between October 2016 and March 2019. Of the polyps found, 36 were hyperplastic (73%). There was no statistically significant difference between HPs and the presence of H. pylori, age, gender, anatomical location of polyps in the stomach, size, number, presence of metaplasia, or atrophy. The mean age was statistically lower in H. pylori-positive cases. Conclusions No correlation was observed between HPs and the presence of H. pylori. There is a need for more extensive, multi-centered, and prospective studies evaluating the relationship between HPs and H. pylori.

Keywords

• Helicobacter pylori
• hyperplastic
• stomach
• polyp

Abstract

Amaç Helikobakter pilori (H. pilori), gram-negatif bakteridir. Üreaz pozitif, hareketli, mikroaerofilik, spiral şekilli olup mide ve proksimal duodenuma yerleşmektedir. Kronik gastrit, mide ülseri, duodenum ülseri, mide kanseri ve MALT Lenfoma gibi hastalıklarla ilişkilidir. Ayrıca metaplazi, gastrik atrofi gibi premalign lezyonlara neden olabilir. H. pilori ile midenin hiperplastik polipleri (HP) arasındaki ilişkiyi araştıran çalışmalar olmasına rağmen bu konudaki belirsizlik sürmektedir. Gereç ve Yöntem Sağlık Bilimleri Üniversitesi Gülhane Eğitim ve Araştırma Hastanesi Gastroenteroloji Kliniği Endoskopi Ünitesinde Ekim 2016 - Mart 2019 tarihleri arasında özofagogastroduodenoskopi yapılan 5378 hastanın verileri retrospektif olarak analiz edildi ve mide polibi saptanan olguların polip patolojileri ve normal mukoza biyopsileri değerlendirildi. Bulgular Ekim 2016 - Mart 2019 arasında verilerin retrospektif taramasında 49 hastada 61 adet mide polibi saptandı. Poliplerin 36’sı (%73) hiperplastik polipti. HP ile H. pilori varlığı, yaş, cinsiyet, polibin midedeki anatomik lokalizasyonu, boyutu, sayısı, metaplazi ve atrofi varlığı açısından istatistiksel olarak anlamlı fark gözlenmedi. H. pilori pozitif olgularda ortalama yaş ise istatistiksel olarak anlamlı şekilde daha düşük bulundu. Sonuç Sonuç olarak; hiperplastik polipler ile H. pilori varlığı arasında korelasyon gözlenmedi. HP ile H. pilori arasındaki ilişkiyi değerlendiren daha büyük sayıda, çok merkezli, prospektif çalışmalara ihtiyaç vardır.

Keywords

• Helikobakter pilori
• hiperplastik
• mide
• polip

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