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Year 2014, Volume: 6 Issue: 3, 38 - 43, 01.12.2014

İzgi E

https://doi.org/10.18521/ktd.93134

Abstract

Objective: It is previously emphasized that mean platelet volume (MPV) is a useful parameter in predicting coronary artery disease and related morbidity and mortality. The purpose of this study is to investigate the relationship between myocardial perfusion scintigraphic findings and mean platelet volume (MPV), which is a simple and reliable parameter of platelet function in patients with suspected coronary heart disease. Methods: In this retrospective study, 344 patients who underwent myocardial perfusion scintigraphy in our clinic between 2009 and 2012 were included. The study group consisted of 139 men and 205 women (mean age 56.67±11,16). Based on the scintigraphic findings, patients were divided into three groups as normal, suspicious for ischemia and significant ischemia. The results of MPV and the parameters obtained from GATED myocardial perfusion SPECT scintigraphy such as stress ejection fraction, end-systolic volumes and enddiastolic volumes were correlated. Results: 96 (27,9%) of the patients were normal, 98 (28,5%) were suspicious for ischemia and 150 (43,6%) showed significant ischemia. MPV values of patients were found to be 8,43±1,19 in normal group, 8,10±1,34 in suspicious ischemic group, 8,06±1,23 in significant ischemic group. There was no significant difference between scintigraphic findings and MPV results. (p=0,060) Conclusion: In our study, it was found that there was not relationship between MPV, which is considered as a risk factor for cardiovascular disease, parameters of GATED myocardial perfusion SPECT scintigraphy and myocardial ischemia

Keywords

Mean Platelet Volume Myocardial Perfusion Scintigraphy

References

  • Endler G, Klimesch A, Sunder-Plassmann H, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br JHaematol. 2002;117:399-404.
  • Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 1561–1571.
  • Grove EL, Orntoft TF, Lassen JF, Jensen HK, Kristensen SD. The platelet polymorphism PlA2 is a genetic risk factor for myocardial infarction. J Intern Med. 2004;255(6):637-44.
  • Demirin H, Ozhan H, Ucgun T, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011; 128(4):358-60.
  • Yang A, Pizzulli L, Lüderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thrombosis Research 2006; 117(4):371—7.
  • Aksu T, Karan A, Guray Y, Guray U, Demirkan B, Korkmaz S. Mean platelet volume and extent of coronary atherosclerosıs ın patıents wıth stable coronary artery dısease. PP-052 International Journal of Cardiology 2010;140(Suppl. 1): S1–S93.
  • Jung DH, Lee HR, Lee YJ, Kim JK, Park BJ, Shim JY. The association between coronary artery calcification and mean platelet volume in the general population. Platelets 2011;22(8):567-71.
  • Hendra TJ, Oswald GA, Yudkin JS. Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure. Diabetes Res Clin Pract 1988; 5: 63-9.
  • Sewell R, Ibbotson RM, Phillips R, Carson P. High mean platelet volume after myocardial infarction:is it due to consumption of small platelets? Br Med J (Clin Res Ed) 1984; 289: 1576-8.
  • Kalay N, Dogdu O, Koc F, et al. Hematologic parameters and angiographic progression of coronary atherosclerosis. Angiology. 2012; 63(3):213-7.
  • Korkmaz L, Korkmaz AA, Akyüz AR, et al. Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study. Anadolu Kardiyol Derg. 2012;12(1):35-9.
  • Murat SN, Duran M, Kalay N, et al. Relation Between Mean Platelet Volume and Severity of Atherosclerosis in Patients With Acute Coronary Syndromes. Angiology. 2012; 64(2):131-6.
  • Han JY, Choi DH, Choi SW, et al. Stroke or coronary artery disease prediction from mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2012 Aug 7. [Epub ahead of print]
  • Demirkol S, Balta S, Unlu M, et al. Evaluation of the mean platelet volume in patients with cardiac syndrome X. Clinics (Sao Paulo). 2012; 67(9):1019-22.
  • Sahin DY, Gür M, Elbasan Z, et al. Mean Platelet Volume and Extent and Complexity of Coronary Artery Disease in Diabetic and Nondiabetic Patients With ST Elevation Myocardial Infarction. Angiology. 2012 Oct 1. [Epub ahead of print].
  • Tavil Y, Sen N, Yazici HU, Hizal F, Abaci A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res. 2007;120(2):245-50.
  • De Luca G, Santagostino M, Secco GG, et al. Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Atherosclerosis. 2009; 206(1):292-7.
  • Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010; 8(1):148-56.
  • Varol E, Akcay S, Ozaydin M, Erdogan D, Dogan A, Altinbas A. Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease. J Cardiol. 2010; 56(2):154-8.
  • Tavil Y, Sen N, Yazici H, et al. Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients. Platelets. 2010; 21(5): 368-72.

Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi

Year 2014, Volume: 6 Issue: 3, 38 - 43, 01.12.2014

İzgi E

https://doi.org/10.18521/ktd.93134

Abstract

Amaç: Koroner arter hastalığını ve ilişkili mortalite ve morbiditeyi öngörmede ortalama platelet hacminin (MPV) kullanışlı bir parametre olduğu daha önce vurgulanmıştır. Bu çalışmanın amacı platelet fonksiyonlarının basit ve güvenilir bir parametresi olan MPV’nin koroner kalp hastalığı şüphesiyle miyokard perfüzyon sintigrafisi çekilen hastalarda sintigrafik bulgularla ilişkisini araştırmaktır. Yöntem: Retrospektif olarak yapılan çalışmamızda 2009-2012 yılları arasında kliniğimizde miyokard perfüzyon sintigrafi incelemesi yapılan 344 hasta alındı. 139 erkek, 205 kadın (ortalama yaş 56.67 ± 11.16) çalışma grubunu oluşturdu. Hastalar sintigrafik sonuçlarına göre normal, şüpheli ve belirgin iskemisi olanlar olarak üç gruba ayrıldı. Stres ejeksiyon fraksiyonu, sistol ve diyastol sonu hacimleri gibi GATED miyokard perfüzyon SPECT sintigrafisinden elde edilen parametreler ile MPV sonuçları istatistiksel olarak karşılaştırıldı. Bulgular: Hastaların 96 (%27,9)’ sı normal, 98 (%28,5)’ i şüpheli iskemik, 150 (%43,6)’ si belirgin iskemik olarak bulundu. Hastaların MPV değerleri normal grupta 8,43±1,19, şüpheli iskemik grupta 8,10±1,34, belirgin iskemik grupta 8,06±1,23 bulundu. Hastalar sintigrafik sonuçları ile MPV sonuçları arasında istatistiksel olarak anlamlı farklılık bulunamadı. (p=0,060) Sonuç: Çalışmamızda kardiyovasküler hastalık açısından risk faktörü olduğu düşünülen MPV’nin GATED miyokard perfüzyon SPECT sintigrafisi parametreleri ve miyokart iskemisi ile ilişkisinin olmadığı bulunmuştur

Keywords

Ortalama Platelet Hacmi Miyokard Perfüzyon Sintigrafisi

References

  • Endler G, Klimesch A, Sunder-Plassmann H, et al. Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br JHaematol. 2002;117:399-404.
  • Kamath S, Blann AD, Lip GY. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 1561–1571.
  • Grove EL, Orntoft TF, Lassen JF, Jensen HK, Kristensen SD. The platelet polymorphism PlA2 is a genetic risk factor for myocardial infarction. J Intern Med. 2004;255(6):637-44.
  • Demirin H, Ozhan H, Ucgun T, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res. 2011; 128(4):358-60.
  • Yang A, Pizzulli L, Lüderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thrombosis Research 2006; 117(4):371—7.
  • Aksu T, Karan A, Guray Y, Guray U, Demirkan B, Korkmaz S. Mean platelet volume and extent of coronary atherosclerosıs ın patıents wıth stable coronary artery dısease. PP-052 International Journal of Cardiology 2010;140(Suppl. 1): S1–S93.
  • Jung DH, Lee HR, Lee YJ, Kim JK, Park BJ, Shim JY. The association between coronary artery calcification and mean platelet volume in the general population. Platelets 2011;22(8):567-71.
  • Hendra TJ, Oswald GA, Yudkin JS. Increased mean platelet volume after acute myocardial infarction relates to diabetes and to cardiac failure. Diabetes Res Clin Pract 1988; 5: 63-9.
  • Sewell R, Ibbotson RM, Phillips R, Carson P. High mean platelet volume after myocardial infarction:is it due to consumption of small platelets? Br Med J (Clin Res Ed) 1984; 289: 1576-8.
  • Kalay N, Dogdu O, Koc F, et al. Hematologic parameters and angiographic progression of coronary atherosclerosis. Angiology. 2012; 63(3):213-7.
  • Korkmaz L, Korkmaz AA, Akyüz AR, et al. Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study. Anadolu Kardiyol Derg. 2012;12(1):35-9.
  • Murat SN, Duran M, Kalay N, et al. Relation Between Mean Platelet Volume and Severity of Atherosclerosis in Patients With Acute Coronary Syndromes. Angiology. 2012; 64(2):131-6.
  • Han JY, Choi DH, Choi SW, et al. Stroke or coronary artery disease prediction from mean platelet volume in patients with type 2 diabetes mellitus. Platelets. 2012 Aug 7. [Epub ahead of print]
  • Demirkol S, Balta S, Unlu M, et al. Evaluation of the mean platelet volume in patients with cardiac syndrome X. Clinics (Sao Paulo). 2012; 67(9):1019-22.
  • Sahin DY, Gür M, Elbasan Z, et al. Mean Platelet Volume and Extent and Complexity of Coronary Artery Disease in Diabetic and Nondiabetic Patients With ST Elevation Myocardial Infarction. Angiology. 2012 Oct 1. [Epub ahead of print].
  • Tavil Y, Sen N, Yazici HU, Hizal F, Abaci A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res. 2007;120(2):245-50.
  • De Luca G, Santagostino M, Secco GG, et al. Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Atherosclerosis. 2009; 206(1):292-7.
  • Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost. 2010; 8(1):148-56.
  • Varol E, Akcay S, Ozaydin M, Erdogan D, Dogan A, Altinbas A. Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease. J Cardiol. 2010; 56(2):154-8.
  • Tavil Y, Sen N, Yazici H, et al. Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients. Platelets. 2010; 21(5): 368-72.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

İzgi E This is me

Publication Date December 1, 2014
Published in Issue Year 2014 Volume: 6 Issue: 3

Cite

APA E, İ. (2014). Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi. Konuralp Medical Journal, 6(3), 38-43. https://doi.org/10.18521/ktd.93134
AMA E İ. Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi. Konuralp Medical Journal. December 2014;6(3):38-43. doi:10.18521/ktd.93134
Chicago E, İzgi. “Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi”. Konuralp Medical Journal 6, no. 3 (December 2014): 38-43. https://doi.org/10.18521/ktd.93134.
EndNote E İ (December 1, 2014) Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi. Konuralp Medical Journal 6 3 38–43.
IEEE İ. E, “Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi”, Konuralp Medical Journal, vol. 6, no. 3, pp. 38–43, 2014, doi: 10.18521/ktd.93134.
ISNAD E, İzgi. “Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi”. Konuralp Medical Journal 6/3 (December 2014), 38-43. https://doi.org/10.18521/ktd.93134.
JAMA E İ. Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi. Konuralp Medical Journal. 2014;6:38–43.
MLA E, İzgi. “Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi”. Konuralp Medical Journal, vol. 6, no. 3, 2014, pp. 38-43, doi:10.18521/ktd.93134.
Vancouver E İ. Ortalama Platelet Hacmi İle Gated Myokard Perfüzyon Spect Sintigrafisinden Elde Edilen Parametrelerin İlişkisi. Konuralp Medical Journal. 2014;6(3):38-43.