Amiodaron Kullanımına Bağlı Gelişen Hipotiroidi Tablosu

Yıl 2018, Cilt: 10 Sayı: 2, 253 - 255, 15.08.2018

Rıdvan Sivritepe Sema Uçak Basat Ece Yiğit Hanife Şerife Aktaş

https://doi.org/10.18521/ktd.289236

Cited By: 2

Öz

Günümüzde ventriküler aritmi, paroksismal supraventriküler taşikardi,
atriyal fibrilasyon, atriyal flutter gibi aritmilerin tedavisinde sıklıkla
kullanılan bir antiaritmik olan amiodoronun en sık ve en önemli yan
etkilerinden biri tiroid disfonksiyonuna sebep olmasıdır. Hastaların büyük
çoğunluğu ötiroid kalmakla birlikte bazılarında tirotoksikoz bazılarında ise
hipotiroidi tablosu ortaya çıkmaktadır. Amiodorona bağlı tirotoksikoz insidansı
%1-23 arasında, hipotiroidi insidansı ise %1-32 arasında değişmektedir.
Vakamızda amiodoron kullanımına bağlı hipotiroidi gelişen bir hastayı sunduk.

Anahtar Kelimeler

Amiodaron, Tiroid Disfonksiyonu, Hipotiroidi

Hypothyroidism Secondary To Amiodarone Use

Öz

In recent years amiodarone is used in the
treatment of arrhythmias such as atrial flutter, ventricular arrhythmia,
paroxysmal supraventricular tachycardia, atrial fibrillation. The most common
and important side effect of amiodarone is to cause thyroid dysfunction.
Although the majority of patients are euthyroid, thyrotoxicosis or
hypothyroidism occurs in some patients. Amiodarone induced thyrotoxicosis
incidence of between 1-23%, and the incidence of hypothyroidism varies between
1-32%. In our case we present a patient with hypothyroidism secondary to
amiodarone use.

Anahtar Kelimeler

Amiodarone, Thyroid Dysfunction, Hypothyroidism

Kaynakça

• Salemo DM, Gillingham KJ, Berry DA, Hodges M A comparison of antiarrhythmic drugs for the suppression of ventricular ectopic depolarisations: A meta-analysis. Am Heart J 120,340-353 ( 1990)
• Basaria, S., & Cooper, D. S. (2005). Amiodarone and the thyroid. The American journal of medicine, 118(7), 706-714.
• Smyrk, T. C., Goellner, J. R., Brennan, M. D., & Carney, J. A. (1987). Pathology of the thyroid in amiodarone-associated thyrotoxicosis. The American journal of surgical pathology, 11(3), 197-204
• Broekhuysen, J.; Laruel, R. and Sion, R.: Recherches dans Ia série des benzofurannes. XXXVII. Étude comparée du transit et du métabolisme de l’amiodarone chez diverses espèces animales et chez l’homme. Archives Internationales de Pharmacodynamie et de Therapie 177: 340–359 (1969)
• Ünal, N., & Gürlek, A. (2005). Amiodaron ve tiroid. Hacettepe Tıp Dergisi, 36, 152-156.
• Haffajee CI, Love JC, Canada AT, Lesko LJ, Asdourian G, Alpert JS: Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias. Circularion 67,1347-1 355 ( 1983)
• Rotmensch HH, Belhassen B, Swanson BN, Shoshani D, Spielman SR, Greenspon kl, Greenspan AM, Vlasses PH, Horowitz LN: Steady-state serum amiodarone concentrations: Relationships with antiarrhythmic efficacy and toxicity. Ann Intern Med 101,462469 (1984)
• Iudica-Souza C, Burch HB 1999 Amiodarone-induced thyroid dysfunction. The Endocrinologist 9:216–227.
• Loh, K. C. (2000). Amiodarone-induced thyroid disorders: a clinical review. Postgraduate medical journal, 76(893), 133-140.
• Amiodaron Trials Meta-Analysis Investigators: Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: metaanalysis of individual data from 6500 patients in randomised trials. Lancet 1997;350:1417-1424.)
• Hohnloser SH, Singh BN. Proarrhythmia with class III antiarrhythmic drugs: definition, electrophysiological mechanisms, incidence, predisposing factors, and clinical implications. J Cardiovasc Electrophysiol 1995;6:920-936.
• Holt DW Tucker GT, Jackson PR, Storey GCA. Amiodarone pharmacokineticks. AM Heart J 1983;106:843-847.
• http://www.acilci.net/amiodaron
• Gopalan, M. (2009). Thyroid dysfunction induced by amiodarone therapy. Updated: Jul, 2.
• ERSOY, C. Ö. (2014). Hipotiroidizm tedavisi. Turkiye Klinikleri Journal of Endocrinology Special Topics, 7(3), 37-40.
• Martino E, Mariotto S, Aghini-Lombardi F, et al. Short term administration of potasyum perchlorate restores euthyroidism in amiodarone iodine induced hypothyroidism. J Clin Endocrinol Metab 1986; 63:1233-6