Gated Miyokard Perfüzyon Spect Çalışmasındaki Stres Defekt Skorları İle Homosistein Düzeylerinin Karşılaştırılması

Yıl 2019, Cilt: 11 Sayı: 1, 69 - 75, 25.03.2019

Ayşe Yılmaz

https://doi.org/10.18521/ktd.432849

Öz

Amaç: Ülkemizde
Koroner Arter Hastalığı (KAH) prevalansı giderek artmakta ve önemli sağlık
sorunlarından biri haline gelmektedir. GATED miyokard perfüzyon SPECT
sintigrafisi KAH tanısı koymada ve prognozu öngörmede kullanılan non-invaziv,
basit ve kolay bir tekniktir. Bu çalışmanın amacı GATED Miyokard Perfüzyon
SPECT çalışmasında elde ettiğimiz stres defekt skorları ile homosistein (HCY)
düzeyini karşılaştırmaktır.

Yöntem:
Kasım/2012-Mart–2013
tarihleri arasında KAH ön tanısı ile MPS için bölümümüze başvuran 166 hasta
çalışmaya dahil edildi. 96 kadın, 70 erkek (ortalama yaş 56±11,6) çalışma
grubunu oluşturdu. Hastalardan alınan kan örneklerinde ELISA metodu ile HCY
seviyesi ölçüldü. Görsel olarak iskemi varlığı değerlendirildi. Sol ventriküle
ait sayısal parametreler kantitatif GATED SPECT (QGS) yazılımı ile otomatik
olarak elde edildi.

Bulgular:
Hastalar
sintigrafi sonuçlarına göre 60 (%57,1)’ı normal, 45 (%42,9)’i iskemik olarak
bulundu. Hastaların HCY düzeyleri normal olan grupta 16,36±9,7 μmol/L
bulunurken, iskemik olan grupta 16,6±8,5 μmol/L bulundu (p=0,895).

Sonuç: Çalışmamızda
HCY düzeyi ile GATED miyokard perfüzyon SPECT çalışmasından elde ettiğimiz
kardiyovasküler risk parametreleri arasında anlamlı bir ilişki bulunmamıştır. 

Anahtar Kelimeler

Koroner Arter Hastalığı, Homosistein, Myokard Perfüzyon Sintigrafisi

The Comparison of Homocysteine Levels with Stress Gated Myocardial Perfusion Defect Scores of the SPECT Study

Öz

Objective: In our country, the prevalence of Coronary Artery Disease (CAD) has been
increasing and becoming one of the most important health problems. GATED SPECT myocardial perfusion scintigraphy is a
non-invasive, simple and easy technique used in diagnosis and predicting
prognosis of CAD. The aim of this study was to compare the level of
Homocysteine (HCY) with stress defect scores that we obtained from GATED
Myocardial Perfusion SPECT study.

Methods: Between November 2012-March 2013,
166 patients with suspected coronary artery disease referred to our department
for the myocardial perfusion scintigraphy included in this study. The study
consisted of 96 women and 70 men (mean age 56±11,6).
HCY levels were measured in blood samples by ELISA. The presence of ischemia was evaluated visually. The
numerical parameters of the left ventricle was obtained automatically by the software
quantitative gated SPECT (QGS).

Results: According to the
scintigraphic results, 60(%57,1)
of the patients were normal and 45(%42,9) of the patients had ischemia. Mean HCY values of
patients were found to be 16,36±9,7 μmol/L in normal group and 16,6±8,5 μmol/L in the ischemic group (p=0,895).

Conclusion: We found no significant correlation between HCY
levels and cardiovascular risk parameters obtained from GATED myocardial
perfusion SPECT.

Anahtar Kelimeler

Coronary Artery Disease, Homocysteine, Myocardial Perfusion Scintigraphy

Kaynakça

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