Perkütan Koroner İşlem Yapılan Hastalarda Klopidogrel Direncinin Klinik Belirteçleri

Year 2019, Volume: 11 Issue: 1, 55 - 61, 25.03.2019

Cem Özde Osman Kayapinar

https://doi.org/10.18521/ktd.444477

Abstract

Keywords

clopidogrel resistance, coronary artery disease, hemoglobin

Clinical Markers of Clopidogrel Resistance in Percutaneous Coronary-Treated Patients

Abstract

Abstart
Objective: Antiplatelet therapy is an indispensable part of current coronary
artery disease and resistance to ADP inhibitors leads to adverse cardiovascular
events in patients. In this study, it was aimed to detect clopidogrel
resistance markers in patients undergoing percutaneous coronary intervention.

METHODS: Eighty consecutive patients (38 clopidogrel
resistance, 42 controls) who underwent percutan intervention procedure due to
coronary artery disease and who had tested positive for clopidogrel resistance at
the end of the first week were included in the study. In the VerifyNow
test,> 208 platelet reactivity unit clopidogrel resistance and> 550
aspirin reaction unit were accepted as aspirin resistance. 28 patients were
treated with ST elevation MI, 18 patients without ST elevation MI, and the
other patients were treated for stable coronary disease. Demographic findings,
CV and family background variables, body mass index, injection fraction,
aspirin resistance and biochemical parameters were compared.

Findings: The mean age of the patients was 59 ± 12 and
15 were female. Subjects with clopidogrel resistance were significantly lower
in Hemoglobin values. Resistance was more frequent in hypertension, while
female sex and smokers were more frequent. Logistic regression analysis showed that
hemoglobin (odds ratio = 0.8; 95% safety interval (0.678-0.945), p = 0.008]
significantly predicted clopidogrel resistance.

Conclusion: Low hemoglobin level predicts clopidogrel
resistance independently of other clinical variables

Keywords

clopidogrel resistance, coronary artery disease, hemoglobin

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