Are the conventional risk factors still valid for acute myeloid leukemia patients?

Year 2020, Volume: 12 Issue: 1, 5 - 11, 02.03.2020

Abdulkerim Yıldız , Senem Maral , Murat Albayrak , Çiğdem Pala Pınar Cömert Hacer Berna Afacan Öztürk , Osman Şahin

https://doi.org/10.18521/ktd.549666

Abstract

Objective: The
aim of this study was to investigate the survival data of patients with acute
myeloid leukemia (AML) and to determine the risk factors that can be easily evaluated.

Method: A
retrospective analysis  was made of the AML patients admitted to our center between
2009-2018. Demographic data and disease data were analyzed and response rates,
overall survival (OS) and progression-free survival (PFS) rates were
calculated. Factors affecting survival were determined using Cox-regression
analysis.

Results: A
total of 119 patients were included in the study during the 9-year study
period. Of these, 21 patients had secondary AML and 11 had acute promyelocytic
leukemia (APL). The mean follow-up period was 12.43 ± 15.63 months. OS of all
patients was 9.20 months and PFS was 7.23 months. Age and leukocyte count at
the time of diagnosis were found to have a significant impact on both OS and
PFS (p <0.05).

Conclusion:
In addition to genetic and molecular features, which are expensive and not
easily available, the age and leukocyte count of AML patients remain important as
prognostic factors.

Keywords

leukemia , survival , age

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