Yıl 2020, Cilt 12 , Sayı 3, Sayfalar 486 - 491 2020-10-20

Amaç: Diyabet Mellitus(DM) en yaygın metabolik hastalıklardan biridir. DM' nin en sık görülen komplikasyonu diyabetik polinöropatidir. Diyabetik polinöropati (DPN) yüksek mortalite, morbidite, hastaneye yatış oranı ve ciddi ekonomik yük ile ilişkilidir. Biz çalışmada DPN patolojisini etkileyen risk faktörlerini belirlemeyi amaçladık.

Yöntem: Sinir iletim çalışmasında anormalliği olan hastalar polinöropati grubunu, anormalliği olmayan hastalar kontrol grubunu oluşturdu. Hastaların laboratuvar değerleri incelendiğinde 202 hastanın 168'inin kan testlerine ulaşıldı. Bu hastaların 117'sinde DPNvarken, 51'inde DPN yoktu.

Bulgular: DPN olan hastalarda glikolize hemoglobin A1c (HbA1c)oranı, açlık kan şekeri DPN olmayan hastalara göre anlamlı olarak yüksek bulundu (p <0,001). DPN’si olan hastalarda HDL oranı DPN’si olamayan hastalara göre düşük saptanırken (p < 0,01), TG/HDL-K oranı daha yüksek saptandı (p < 0,05). DPN olan hastalarda glikolize üre (p < 0,001) ve kreatinin (p < 0,01), DPN olmayan hastalara göre anlamlı olarak yüksek saptandı. DPN olan hastalarda 25(OH) vitamin D düzeyi DPN olmayan hastalara göre anlamlı olarak düşüktü (p < 0,05). DPN olan hastalarda ferritin, olmayan hastalara göre anlamlı olarak daha yüksek saptandı (p <0 ,01).

Sonuç: Diyabetik polinöropati açısından risk faktörlerinin bilinmesi ve önlenmesi ile tedavi yaklaşımlarımıza yeni bir yön vererek erken önlemler alabiriz. Açlık kan şekeri, HbA1ckontrolü, lipid profilinin düzenlenmesi, 25(OH) vitamin D düzeyive ferritin düzeylerinin takibi özellikle korunma açısından önemlidir.

Objective: Diabetes Mellitus is one of the most common metabolic diseases. The most frequent complication of DM is diabetic polyneuropathy.Diabetic polyneuropathy is related to high mortality, morbidity, hospitalization rate and serious level of economic burden. We aimed in this study to determine the risk factors that affect DPN pathology.

Method: Patients with abnormalities in the nerve conduction study constituted the polyneuropathy group, and patients without abnormalities formed the control group When the laboratuary values of the patients were analyzed, blood tests of 168 of 202 patients were reached. 117 of these patients had PNP and 51 did not have PNP.

Results: In patients with PNP, glycolyzed hba1c ratio and fasting blood sugar were significantly higher than patients without PNP. (p <.001) While HDL rate was lower in patients with PNP than those without PNP (p <0.01), TG / HDL ratio was higher (p <0.05). In patients with PNP, glycolyzed urea (p <0.001) and creatinine (p <0.01) were significantly higher than those without PNP. The serum level of 25 (OH) vitamin D was significantly lower in patients with PNP than in patients without PNP (p <0.05). Ferritin was significantly higher in patients with PNP than patients without (P <0 .01).

Conclusion: Knowing and preventing risk factors for diabetic polyneuropathy, we can take a new direction to our treatment approaches and take early measures. Fasting blood sugar and hba1c control, regulation of lipid profile, monitoring of vitamin d and ferritin levels are particularly necessary for protection of polyneuropathy.

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Orcid: 0000-0002-1444-5022
Yazar: Esra ACİMAN DEMİREL (Sorumlu Yazar)
Kurum: BULENT ECEVIT UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY
Ülke: Turkey


Orcid: 0000-0003-3171-1123
Yazar: Burcu KARPUZ
Kurum: BULENT ECEVIT UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY
Ülke: Turkey


Orcid: 0000-0001-5785-3379
Yazar: Ulufer ÇELEBİ
Kurum: BULENT ECEVIT UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY
Ülke: Turkey


Orcid: 0000-0002-0645-5765
Yazar: Mustafa AÇIKGÖZ
Kurum: BULENT ECEVIT UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY
Ülke: Turkey


Orcid: 0000-0003-1631-7400
Yazar: Hüsyin Tuğrul ATASOY
Kurum: BULENT ECEVIT UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF NEUROLOGY
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 20 Ekim 2020

Bibtex @araştırma makalesi { ktd744679, journal = {Konuralp Medical Journal}, issn = {1309-3878}, eissn = {1309-3878}, address = {}, publisher = {Düzce Üniversitesi}, year = {2020}, volume = {12}, pages = {486 - 491}, doi = {10.18521/ktd.744679}, title = {Risk Factors For Diabetic Polyneuropathy}, key = {cite}, author = {Aciman Demirel, Esra and Karpuz, Burcu and Çelebi, Ulufer and Açıkgöz, Mustafa and Atasoy, Hüsyin Tuğrul} }
APA Aciman Demirel, E , Karpuz, B , Çelebi, U , Açıkgöz, M , Atasoy, H . (2020). Risk Factors For Diabetic Polyneuropathy . Konuralp Medical Journal , 12 (3) , 486-491 . DOI: 10.18521/ktd.744679
MLA Aciman Demirel, E , Karpuz, B , Çelebi, U , Açıkgöz, M , Atasoy, H . "Risk Factors For Diabetic Polyneuropathy" . Konuralp Medical Journal 12 (2020 ): 486-491 <https://dergipark.org.tr/tr/pub/ktd/issue/57326/744679>
Chicago Aciman Demirel, E , Karpuz, B , Çelebi, U , Açıkgöz, M , Atasoy, H . "Risk Factors For Diabetic Polyneuropathy". Konuralp Medical Journal 12 (2020 ): 486-491
RIS TY - JOUR T1 - Risk Factors For Diabetic Polyneuropathy AU - Esra Aciman Demirel , Burcu Karpuz , Ulufer Çelebi , Mustafa Açıkgöz , Hüsyin Tuğrul Atasoy Y1 - 2020 PY - 2020 N1 - doi: 10.18521/ktd.744679 DO - 10.18521/ktd.744679 T2 - Konuralp Medical Journal JF - Journal JO - JOR SP - 486 EP - 491 VL - 12 IS - 3 SN - 1309-3878-1309-3878 M3 - doi: 10.18521/ktd.744679 UR - https://doi.org/10.18521/ktd.744679 Y2 - 2020 ER -
EndNote %0 Konuralp Tıp Dergisi Risk Factors For Diabetic Polyneuropathy %A Esra Aciman Demirel , Burcu Karpuz , Ulufer Çelebi , Mustafa Açıkgöz , Hüsyin Tuğrul Atasoy %T Risk Factors For Diabetic Polyneuropathy %D 2020 %J Konuralp Medical Journal %P 1309-3878-1309-3878 %V 12 %N 3 %R doi: 10.18521/ktd.744679 %U 10.18521/ktd.744679
ISNAD Aciman Demirel, Esra , Karpuz, Burcu , Çelebi, Ulufer , Açıkgöz, Mustafa , Atasoy, Hüsyin Tuğrul . "Risk Factors For Diabetic Polyneuropathy". Konuralp Medical Journal 12 / 3 (Ekim 2020): 486-491 . https://doi.org/10.18521/ktd.744679
AMA Aciman Demirel E , Karpuz B , Çelebi U , Açıkgöz M , Atasoy H . Risk Factors For Diabetic Polyneuropathy. Konuralp Medical Journal. 2020; 12(3): 486-491.
Vancouver Aciman Demirel E , Karpuz B , Çelebi U , Açıkgöz M , Atasoy H . Risk Factors For Diabetic Polyneuropathy. Konuralp Medical Journal. 2020; 12(3): 486-491.
IEEE E. Aciman Demirel , B. Karpuz , U. Çelebi , M. Açıkgöz ve H. Atasoy , "Risk Factors For Diabetic Polyneuropathy", Konuralp Medical Journal, c. 12, sayı. 3, ss. 486-491, Eki. 2020, doi:10.18521/ktd.744679