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COVID-19 Pandemisi Öncesi ve Sonrası Alt Ekstremite Venöz Doppler Ultrasonografi Sonuçlarının Değerlendirilmesi; Retrospektif Bir Çalışma

Year 2024, Volume: 16 Issue: 3, 273 - 277, 29.10.2024
https://doi.org/10.18521/ktd.1439434

Abstract

Amaç: COVID-19 testi pozitifliği asemptomatik bireyler arasında bildirilmiştir ve asemptomatik kişilerin de tromboembolik olaylar için risk altında olduğu düşünülmektedir. Bu çalışmanın amacı, COVID-19 testinden bağımsız olarak, pandemi öncesi ve sonrasında derin ven trombozu (DVT) ön tanısıyla alt ekstremite Doppler ultrasonografisi (DUS) yapılan hastaların sonuçlarını karşılaştırmaktır.
Yöntem: Toplam 35 aylık süre boyunca (01/08/2018 - 01/07/2021) Radyoloji Bölümünde RDUS yapılan hastalar analiz edildi. Çalışma dönemi boyunca toplam 599 hastaya RDUS yapılmıştır.
Bulgular: Pandemi sonrasında daha fazla pozitif DVT bulgusu gözlenmiştir (n=43, %18,3, p=0,005) (bu hastaların yalnızca ikisinde pozitif COVID-19 sonucu vardı). Son üç ay içinde hastaneye yatış öyküsü, D-dimer, platelet (PLT), ortalama platelet hacmi (MPV), (lökosit sayısı) WBC, nötrofil sayısı, lenfosit sayısı, nötrofil/ lenfosit oranı (NLR) değerleri, komorbidite ve antiagregan kullanımı farklı değildi (p>0.05).
Sonuç: Pandemi sırasında virüse maruz kalan ancak semptom göstermeyen bireyler (özellikle yaşlı bireyler) bile DVT riski altındadır.

References

  • 1. Altınsoy HB, Çalışkan E, Şahin İE, Naldemir İ, Karadağ M, Boğan M. Acil Pandemi Polikliniğine Başvuran ve COVID-19 Şüphesiyle Değerlendirilen Hastaların Retrospektif Analizi. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2021;11(2):171-5.
  • 2. Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, et al. Presumed asymptomatic carrier transmission of COVID-19. Jama. 2020;323(14):1406-7.
  • 3. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. In: Statpearls [internet]. Treasure Island (FL): StatPearls Publishing; 2020 [Last updated 20/10/2020; Accessed 15/06/2020]. Accessed on https://www.ncbi.nlm.nih.gov/books/NBK554776/.
  • 4. Tersalvi G, Vicenzi M, Calabretta D, Biasco L, Pedrazzini G, Winterton D. Elevated troponin in patients with Coronavirus Disease 2019 (COVID-19): possible mechanisms. J Card Fail. 2020;26(6):470-5.
  • 5. Suh YJ, Hong H, Ohana M, Bompard F, Revel MP, Valle C, et al. Pulmonary embolism and deep vein thrombosis in COVID-19: a systematic review and meta-analysis. Radiology. 2021;298(2):E70-80.
  • 6. Jung J, Kim J, Lim JS, Kim EO, Kim MN, Kim SH. Pitfall of universal pre-admission screening for SARS-CoV-2 in a low prevalence country. Viruses. 2021;13(5):804.
  • 7. Ford JS, Parikh A, Sandhu R, Turnipseed S, Morris B, May L, et al. Testing Asymptomatic Emergency Department Patients for Coronavirus Disease 2019 (COVID‐19) in a Low‐prevalence Region. Academic Emergency Medicine. 2020;27(8):771.
  • 8. Boccatonda A, Campello E, Simion C, Simioni P. Long-term hypercoagulability, endotheliopathy and inflammation following acute SARS-CoV-2 infection. Expert Rev Hematol. 2023;16(12):1035-48.
  • 9. Waheed SM, Kudaravalli P, Hotwagner DT. Deep Vein Thrombosis. [Updated 2023 Jan 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507708/.
  • 10. Bagheri B, Alipour A, Yousefi M, Jalalian R, Moghimi M, Mohammadi M, Hassanpour N, Iranian M. Prevalence of Thromboembolic Events, Including Venous Thromboembolism and Arterial Thrombosis, in Patients with COVID-19: A Systematic Review with Meta-Analysis. J Tehran Heart Cent. 2023;18(3):154-69.
  • 11. Saliba OA, Alves AFJ, Matarazzo C, Gonçalves GT, Sobreira ML. Deep vein thrombosis of lower limbs in patients with COVID-19. J Vasc Bras. 2023;22:e20230027.
  • 12. Mosevoll KA, Johansen S, Wendelbo Ø, Nepstad I, Bruserud Ø, Reikvam H. Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis. Front Med (Lausanne). 2018;5:147.
  • 13. Kurtuluş M, Pirim İ. Covid-19 ve Sitokin fırtınası. Forbes J Med. 2020;1(3):55-60.
  • 14. Jing H, Wu X, Xiang M, Liu L, Novakovic VA, Shi J. Pathophysiological mechanisms of thrombosis in acute and long COVID-19. Front Immunol. 2022;13:992384.
  • 15. Fenyves BG, Mehta A, Kays KR. MGH COVID-19 collection & processing team, Goldberg MB, hacohen n, filbin MR. plasma p-selectin is an early marker of thromboembolism in COVID-19. Am J Hematol. 2021; 96(12):E468-E471.
  • 16. Barrett TJ, Bilaloglu S, Cornwell M, Burgess HM, Virginio VW, Drenkova K, et al. Platelets contribute to disease severity in COVID-19. J Thromb Haemost. 2021;19(12):3139–53.
  • 17. Yamamoto C, Nukui Y, Furukawa K, Taniguchi M, Yamano T, Inaba T, Kikai R, Tanino Y, Yamada Y, Teramukai S, Takayama K. SARS-CoV-2 RT-PCR as a universal screening on planned admission in asymptomatic patients. J Infect Chemother. 2023:S1341-321X(23)00314-8.
  • 18. Sangal RB, Peaper DR, Rothenberg C, Landry ML, Sussman LS, Martinello RA, et al. Universal SARS-CoV-2 testing of emergency department admissions increases emergency department length of stay. Annals of Emergency Medicine. 2022;79(2):182-6.

Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study

Year 2024, Volume: 16 Issue: 3, 273 - 277, 29.10.2024
https://doi.org/10.18521/ktd.1439434

Abstract

Objectives: COVID-19 PCR positivity has been reported among asymptomatic individuals and asymptomatic people are also considered to be at risk for thromboembolic events. The aim of this study was to compare the results of patients who underwent lower extremity Doppler ultrasonography (DUS) with a preliminary diagnosis of deep vein thrombosis (DVT) before and after the pandemic, regardless of COVID-19 PCR testing.
Methods: Patients who underwent RDUS in the Department of Radiology during a total period of 35 months (01/08/2018 - 01/07/2021) were analyzed. A total of 599 patients underwent RDUS during the study period.
Results: More pozitif DVT findings were observed after the pandemic (n=43, 18.3%, p=0.005) (only two of these patients had a positive COVID-19 PCR result). History of hospitalization in the last three months, D-dimer, PLT, MPV, WBC, neutrophil count, lymphocyte count, NLR values, comorbidity and antiaggregant use were not different (p>0.05).
Conclusion: Even individuals (especially elderly individuals) who have been exposed to the virus during the pandemic but who do not show symptoms are at risk of DVT.

References

  • 1. Altınsoy HB, Çalışkan E, Şahin İE, Naldemir İ, Karadağ M, Boğan M. Acil Pandemi Polikliniğine Başvuran ve COVID-19 Şüphesiyle Değerlendirilen Hastaların Retrospektif Analizi. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2021;11(2):171-5.
  • 2. Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, et al. Presumed asymptomatic carrier transmission of COVID-19. Jama. 2020;323(14):1406-7.
  • 3. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. In: Statpearls [internet]. Treasure Island (FL): StatPearls Publishing; 2020 [Last updated 20/10/2020; Accessed 15/06/2020]. Accessed on https://www.ncbi.nlm.nih.gov/books/NBK554776/.
  • 4. Tersalvi G, Vicenzi M, Calabretta D, Biasco L, Pedrazzini G, Winterton D. Elevated troponin in patients with Coronavirus Disease 2019 (COVID-19): possible mechanisms. J Card Fail. 2020;26(6):470-5.
  • 5. Suh YJ, Hong H, Ohana M, Bompard F, Revel MP, Valle C, et al. Pulmonary embolism and deep vein thrombosis in COVID-19: a systematic review and meta-analysis. Radiology. 2021;298(2):E70-80.
  • 6. Jung J, Kim J, Lim JS, Kim EO, Kim MN, Kim SH. Pitfall of universal pre-admission screening for SARS-CoV-2 in a low prevalence country. Viruses. 2021;13(5):804.
  • 7. Ford JS, Parikh A, Sandhu R, Turnipseed S, Morris B, May L, et al. Testing Asymptomatic Emergency Department Patients for Coronavirus Disease 2019 (COVID‐19) in a Low‐prevalence Region. Academic Emergency Medicine. 2020;27(8):771.
  • 8. Boccatonda A, Campello E, Simion C, Simioni P. Long-term hypercoagulability, endotheliopathy and inflammation following acute SARS-CoV-2 infection. Expert Rev Hematol. 2023;16(12):1035-48.
  • 9. Waheed SM, Kudaravalli P, Hotwagner DT. Deep Vein Thrombosis. [Updated 2023 Jan 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507708/.
  • 10. Bagheri B, Alipour A, Yousefi M, Jalalian R, Moghimi M, Mohammadi M, Hassanpour N, Iranian M. Prevalence of Thromboembolic Events, Including Venous Thromboembolism and Arterial Thrombosis, in Patients with COVID-19: A Systematic Review with Meta-Analysis. J Tehran Heart Cent. 2023;18(3):154-69.
  • 11. Saliba OA, Alves AFJ, Matarazzo C, Gonçalves GT, Sobreira ML. Deep vein thrombosis of lower limbs in patients with COVID-19. J Vasc Bras. 2023;22:e20230027.
  • 12. Mosevoll KA, Johansen S, Wendelbo Ø, Nepstad I, Bruserud Ø, Reikvam H. Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis. Front Med (Lausanne). 2018;5:147.
  • 13. Kurtuluş M, Pirim İ. Covid-19 ve Sitokin fırtınası. Forbes J Med. 2020;1(3):55-60.
  • 14. Jing H, Wu X, Xiang M, Liu L, Novakovic VA, Shi J. Pathophysiological mechanisms of thrombosis in acute and long COVID-19. Front Immunol. 2022;13:992384.
  • 15. Fenyves BG, Mehta A, Kays KR. MGH COVID-19 collection & processing team, Goldberg MB, hacohen n, filbin MR. plasma p-selectin is an early marker of thromboembolism in COVID-19. Am J Hematol. 2021; 96(12):E468-E471.
  • 16. Barrett TJ, Bilaloglu S, Cornwell M, Burgess HM, Virginio VW, Drenkova K, et al. Platelets contribute to disease severity in COVID-19. J Thromb Haemost. 2021;19(12):3139–53.
  • 17. Yamamoto C, Nukui Y, Furukawa K, Taniguchi M, Yamano T, Inaba T, Kikai R, Tanino Y, Yamada Y, Teramukai S, Takayama K. SARS-CoV-2 RT-PCR as a universal screening on planned admission in asymptomatic patients. J Infect Chemother. 2023:S1341-321X(23)00314-8.
  • 18. Sangal RB, Peaper DR, Rothenberg C, Landry ML, Sussman LS, Martinello RA, et al. Universal SARS-CoV-2 testing of emergency department admissions increases emergency department length of stay. Annals of Emergency Medicine. 2022;79(2):182-6.
There are 18 citations in total.

Details

Primary Language English
Subjects Health Services and Systems (Other)
Journal Section Articles
Authors

Mustafa Boğan 0000-0002-3238-1827

Melih Bal 0000-0002-5593-3540

Tarık Gürdal 0009-0005-7273-2627

Kudret Selki 0000-0002-3495-4991

Abdulkadir Kaya 0000-0003-1725-1220

Özkan Kömürcü 0009-0002-4444-3244

Hasan Baki Altınsoy 0000-0003-0934-3600

Publication Date October 29, 2024
Submission Date February 19, 2024
Acceptance Date July 4, 2024
Published in Issue Year 2024 Volume: 16 Issue: 3

Cite

APA Boğan, M., Bal, M., Gürdal, T., Selki, K., et al. (2024). Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study. Konuralp Medical Journal, 16(3), 273-277. https://doi.org/10.18521/ktd.1439434
AMA Boğan M, Bal M, Gürdal T, Selki K, Kaya A, Kömürcü Ö, Altınsoy HB. Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study. Konuralp Medical Journal. October 2024;16(3):273-277. doi:10.18521/ktd.1439434
Chicago Boğan, Mustafa, Melih Bal, Tarık Gürdal, Kudret Selki, Abdulkadir Kaya, Özkan Kömürcü, and Hasan Baki Altınsoy. “Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study”. Konuralp Medical Journal 16, no. 3 (October 2024): 273-77. https://doi.org/10.18521/ktd.1439434.
EndNote Boğan M, Bal M, Gürdal T, Selki K, Kaya A, Kömürcü Ö, Altınsoy HB (October 1, 2024) Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study. Konuralp Medical Journal 16 3 273–277.
IEEE M. Boğan, M. Bal, T. Gürdal, K. Selki, A. Kaya, Ö. Kömürcü, and H. B. Altınsoy, “Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study”, Konuralp Medical Journal, vol. 16, no. 3, pp. 273–277, 2024, doi: 10.18521/ktd.1439434.
ISNAD Boğan, Mustafa et al. “Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study”. Konuralp Medical Journal 16/3 (October 2024), 273-277. https://doi.org/10.18521/ktd.1439434.
JAMA Boğan M, Bal M, Gürdal T, Selki K, Kaya A, Kömürcü Ö, Altınsoy HB. Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study. Konuralp Medical Journal. 2024;16:273–277.
MLA Boğan, Mustafa et al. “Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study”. Konuralp Medical Journal, vol. 16, no. 3, 2024, pp. 273-7, doi:10.18521/ktd.1439434.
Vancouver Boğan M, Bal M, Gürdal T, Selki K, Kaya A, Kömürcü Ö, Altınsoy HB. Evaluation of Lower Extremity Venous Doppler Ultrasonography Outcomes Before And After The COVID-19 Pandemic; A Retrospective Study. Konuralp Medical Journal. 2024;16(3):273-7.