Gestasyonel Diyabetes Mellitus Patogenezinde AB0 Kan Grubu Fenotipleri ve Rhesus Faktörü
Yıl 2024,
Cilt: 16 Sayı: 3, 278 - 282, 29.10.2024
Adem Keskin
,
Recai Aci
,
Mukadder Erdem
,
Eda Türe
,
Mahcube Cubukcu
Öz
Amaç: Bazı AB0 kan grubu fenotipleri hem tip II diabetes mellitus (DM) hem de tip I DM'nin patogenezinde risk faktörü olarak kabul edilebilir. Bu çalışmanın amacı, bazı AB0 kan grubu fenotiplerinin ve Rhesus (Rh) faktörünün, gestasyonel diabetes mellitus (GDM) tanısı almış gebe kadınlarda hastalığın ortaya çıkması için risk faktörü olup olmadığını araştırmaktır.
Metod: Bu çalışma bir vaka-kontrol çalışması olup veriler retrospektif olarak analiz edildi. Bir eğitim ve araştırma hastanesine bir yıl süreyle başvuran ve 75 gram oral glukoz tolerans testi (OGTT) yaptıran gebe kadınlar çalışmaya dahil edildi. OGTT sonuçlarına göre GDM tanısı almış gebe kadınlar (vaka grubu) ve sağlıklı gebe kadınlar (kontrol grubu) iki gruba ayrıldı.
Bulgular: Bir yıllık veri taramasında GDM prevalansı %15,94 olarak bulundu. GDM'li gebelerin yaş ortalaması sağlıklı gebelere göre daha yüksek bulundu (p<0,001). GDM'li gebeler ile sağlıklı gebelerde AB0 kan grubunun yüzdelik frekans dağılımları arasında anlamlı bir fark yoktu (p>0,05). Her iki grubun Rh faktörü pozitifliği farklı değildi (p>0,05).
Sonuç: Sonuç olarak GDM patogenezi ve AB0 kan grubu fenotipleri ile Rh faktörü arasında bir ilişki bulunamadı.
Kaynakça
- Alejandro EU, Mamerto TP, Chung G, Villavieja A, Gaus NL, Morgan E, et al. Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes. Int J Mol Sci. 2020;21(14):5003.
- 2. Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications. Trends Endocrinol Metab. 2018;29(11):743-54.
- 3. Juan J, Yang H. Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China. Int J Environ Res Public Health. 2020;17(24):9517.
- 4. Gilmiyarova FN, Kolotyeva NA, Kuzmicheva VI, Gusyakova OA, Borodina IA, Baisheva GM, et al. [Blood group and human diseases (review of literature).]. Klin Lab Diagn. 2020;65(4):216-21. Russian.
- 5. Cendal IM, Krolak-Olejnik B. Relationship between AB0 blood groups and selected pregnancy conditions and neonatal diseases. Ginekol Pol. 2021;92(11):818-21.
- 6. Telesmanich NR, Konoval Chik MA, Mikashinovich ZI. [The analysis of level of total immunoglobulin E (IgE) in blood serum of patients with various types of disorders of carbohydrate metabolism and blood groups 0 (I), A (II) and B (III).]. Klin Lab Diagn. 2017;62(8):476-81. Russian.
- 7. Meo SA, Rouq FA, Suraya F, Zaidi SZ. Association of ABO and Rh blood groups with type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci. 2016;20(2):237-42.
- 8. Dahlquist GG, Patterson C, Soltesz G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diabetes Care. 1999;22(10):1698-702.
- 9. Franchini M, Mengoli C, Lippi G. Relationship between ABO blood group and pregnancy complications: a systematic literature analysis. Blood Transfus. 2016;14(5):441-8.
- 10. Chen QH, Chen Q, Zhang L, Hu YY. [Relationship Between ABO Blood Group and Pregnancy Complications]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2022;53(5):935-40. Chinese.
- 11. Karagoz H, Erden A, Ozer O, Esmeray K, Cetinkaya A, Avci D, Karahan S, Basak M, Bulut K, Mutlu H, Simsek Y. The role of blood groups in the development of diabetes mellitus after gestational diabetes mellitus. Ther Clin Risk Manag. 2015;11:1613-7.
- 12. Shibata-Hiraizumi Y, Suzuki S. Maternal ABO blood group and adverse pregnancy outcomes in Japanese population. J Perinatol. 2013;33(9):743.
- 13. Waters TP, Dyer AR, Scholtens DM, Dooley SL, Herer E, Lowe LP, et al. Maternal and Neonatal Morbidity for Women Who Would Be Added to the Diagnosis of GDM Using IADPSG Criteria: A Secondary Analysis of the Hyperglycemia and Adverse Pregnancy Outcome Study. Diabetes Care. 2016;39(12):2204-10.
- 14. Wang H, Li N, Chivese T, Werfalli M, Sun H, Yuen L, et al. IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group's Criteria. Diabetes Res Clin Pract. 2022;183:109050.
- 15. Dean L. Blood Groups and Red Cell Antigens [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2005. Chapter 5, The ABO blood group. [cited 20 Jun 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK2267/
- 16. Koenigbauer JT, Fangmann L, Rostin P, Balke S, Weid P, Henrich W, et al. Advanced maternal age (AMA) and 75 g oGTT glucose levels are pedictors for insulin therapy in women with gestational diabetes (GDM). J Perinat Med. 2023;51(9):1154-62.
- 17. Sun M, Luo M, Wang T, Wei J, Zhang S, Shu J, et al. Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China. BMJ Open Diabetes Res Care. 2023;11(2):e003324.
AB0 Blood Group Phenotypes and Rhesus Factor in The Pathogenesis of Gestational Diabetes Mellitus
Yıl 2024,
Cilt: 16 Sayı: 3, 278 - 282, 29.10.2024
Adem Keskin
,
Recai Aci
,
Mukadder Erdem
,
Eda Türe
,
Mahcube Cubukcu
Öz
Objective: Some AB0 blood group phenotypes may be considered as risk factors in the pathogenesis of both type II diabetes mellitus (DM) and type I DM. The aim of this research was to investigate whether there is a relation between AB0 blood group phenotypes and Rhesus (Rh) factor and the occurrence of the disease in pregnant female diagnosed with gestational diabetes mellitus (GDM).
Method: This research was case-control research, and the data were analyzed retrospectively. Pregnant women who were admitted to a research and teaching hospital for one year and underwent a 75 gram oral glucose tolerance test (OGTT) were included in the research. Pregnant females diagnosed with GDM according to OGTT results were separated into two groups as case group and healthy pregnant females as control group.
Result: The prevalence of GDM was found to be 15.94% in a one-year data review. The mean age of pregnant females with GDM was higher than healthy pregnant females (p<0.001). There was no important difference between the percentage frequency distribution of AB0 blood group in pregnant females with GDM and healthy pregnant females (p>0.05). Rh factor positivity of both groups was not different (p>0.05).
Conclusion: In conclusion, no association was found between the pathogenesis of GDM and AB0 blood group phenotypes and Rh factor.
Teşekkür
We would like to express our gratitude to the blood center and laboratory staff of the hospital where this study was conducted and to the hospital administration for providing us with all kinds of facilities during our study. We would also like to express our gratitude to Assoc. Prof. Dr. Canan Soyer Çalışkan, Chief of Gynecology and Obstetrics Clinic, who approved the conduct of our study.
Kaynakça
- Alejandro EU, Mamerto TP, Chung G, Villavieja A, Gaus NL, Morgan E, et al. Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes. Int J Mol Sci. 2020;21(14):5003.
- 2. Johns EC, Denison FC, Norman JE, Reynolds RM. Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications. Trends Endocrinol Metab. 2018;29(11):743-54.
- 3. Juan J, Yang H. Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China. Int J Environ Res Public Health. 2020;17(24):9517.
- 4. Gilmiyarova FN, Kolotyeva NA, Kuzmicheva VI, Gusyakova OA, Borodina IA, Baisheva GM, et al. [Blood group and human diseases (review of literature).]. Klin Lab Diagn. 2020;65(4):216-21. Russian.
- 5. Cendal IM, Krolak-Olejnik B. Relationship between AB0 blood groups and selected pregnancy conditions and neonatal diseases. Ginekol Pol. 2021;92(11):818-21.
- 6. Telesmanich NR, Konoval Chik MA, Mikashinovich ZI. [The analysis of level of total immunoglobulin E (IgE) in blood serum of patients with various types of disorders of carbohydrate metabolism and blood groups 0 (I), A (II) and B (III).]. Klin Lab Diagn. 2017;62(8):476-81. Russian.
- 7. Meo SA, Rouq FA, Suraya F, Zaidi SZ. Association of ABO and Rh blood groups with type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci. 2016;20(2):237-42.
- 8. Dahlquist GG, Patterson C, Soltesz G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diabetes Care. 1999;22(10):1698-702.
- 9. Franchini M, Mengoli C, Lippi G. Relationship between ABO blood group and pregnancy complications: a systematic literature analysis. Blood Transfus. 2016;14(5):441-8.
- 10. Chen QH, Chen Q, Zhang L, Hu YY. [Relationship Between ABO Blood Group and Pregnancy Complications]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2022;53(5):935-40. Chinese.
- 11. Karagoz H, Erden A, Ozer O, Esmeray K, Cetinkaya A, Avci D, Karahan S, Basak M, Bulut K, Mutlu H, Simsek Y. The role of blood groups in the development of diabetes mellitus after gestational diabetes mellitus. Ther Clin Risk Manag. 2015;11:1613-7.
- 12. Shibata-Hiraizumi Y, Suzuki S. Maternal ABO blood group and adverse pregnancy outcomes in Japanese population. J Perinatol. 2013;33(9):743.
- 13. Waters TP, Dyer AR, Scholtens DM, Dooley SL, Herer E, Lowe LP, et al. Maternal and Neonatal Morbidity for Women Who Would Be Added to the Diagnosis of GDM Using IADPSG Criteria: A Secondary Analysis of the Hyperglycemia and Adverse Pregnancy Outcome Study. Diabetes Care. 2016;39(12):2204-10.
- 14. Wang H, Li N, Chivese T, Werfalli M, Sun H, Yuen L, et al. IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group's Criteria. Diabetes Res Clin Pract. 2022;183:109050.
- 15. Dean L. Blood Groups and Red Cell Antigens [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2005. Chapter 5, The ABO blood group. [cited 20 Jun 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK2267/
- 16. Koenigbauer JT, Fangmann L, Rostin P, Balke S, Weid P, Henrich W, et al. Advanced maternal age (AMA) and 75 g oGTT glucose levels are pedictors for insulin therapy in women with gestational diabetes (GDM). J Perinat Med. 2023;51(9):1154-62.
- 17. Sun M, Luo M, Wang T, Wei J, Zhang S, Shu J, et al. Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China. BMJ Open Diabetes Res Care. 2023;11(2):e003324.