Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2019, Cilt: 7 Sayı: 1, 8 - 14, 30.06.2019
https://doi.org/10.24998/maeusabed.539891

Öz

Kaynakça

  • Aggarwal, B.B., 2010. Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals, Annu Rev Nutr., 21;30:173-99.Aggarwal, B.B., 2010. Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals, Annu Rev Nutr. 21;30:173-99.Aggarwal, B.B., 2013. Curcumin-free tumeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of tumeric. Mol Nutr Food Res;57,1529-42. Aggarwal, BB., Kumar, A., Bharti, AC., 2003. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Anticancer Research ; 23: 363-398.Aggarwal, BB., Sundaram, C., Malani, N., Ichikawa, H., 2007. Curcumin: The Indian solid gold. Adv Exp Med Biol; 595,1–75.Ak, T. and Gulcin, I., 2008. Antioxidant and radical scavenging properties of curcumin Chemico-Biological Interactions.;174, 27–37. Ammon, H. P. T., Anazoda, M. I., Safayhi, H., Dhawan, B. N. and Srimal R. C., 1992. Curcumin: A potent inhibitor of Leukotriene B4 formation in rat peritoneal polymorphonuclear neutrophils (PMNL), Planta Medica. 58, 26-28.Anand, P., Kunnumakkara, AB., Newman, RA., Aggarwal, BB.. 2007. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics 4: 807-818.Änderung L. Curcuma – Sechs Tipps zur richtigen Anwendung. (https://www.z entrum-der-gesundheit.de/curcuma-anwendung-ia.html). Accsess Date: 13.05.2018.Araújo, CC., Leon, LL., 2001. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz; 96(5):723-8.Aslan, R., Kutlu, R., Civi, S., Tasyurek, E., 2014. The correlation of the total antioxidant status (TAC), total oxidant status (TOC) and paraoxonase activity (PON1) with smoking. Clin Biochem; 47(6): 393-397. Auddy, B., Ferreira, M., Blasina, F., Lafon, L., Arredondo, F., Dajas, F., Tripathi, P.C., Seal, T. and Murkerjee, B., 2003. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases, Journal of Ethnopharmacology, 84, 131-138.Belviranlı, M., Okudan, N., Atalık, KEN., 2012. Effects of curcumin supplementation on oxidant/antioxidant status of heart tissue in aged rats, Genel Tıp Derg; 22(2):61-66.Delgado-Vargas, F., and Paredes-López, O., (Eds): 2003. Natural colorants for food and nutraceutical uses. CRC Press.Duan, W., Yang, Y., Yan, J., Yu, S., Liu, J., Zhou, J., et al,. 2012. The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway. Basic Res Cardiol. 107:263.Dündar, Y., Aslan, R., 1999. Hücre Moleküler Statüsünün Anlaşılması ve Fizyolojik Önem Açısından Radikaller, Antioksidanlar. İnsizyon Cerrahi Tıp Bilim Dergisi. 2(2): 134-142.Goel, A., Kunnumakkara, AB., Aggarwal, BB., 2008. Curcumin as “curecumin”: from kitchen to clinic. Biochem Pharmacol; 75(4):787- 809.Hatchera, R., Planalpb, J., Chob, F., M Tortia, Tortic, SV., 2008. Review Curcumin: From ancient medicine to current clinical trials H. Cell. Mol. Life Sci; (65), 1631 – 1652.Isik, A., 2007. The Efficiency of Curcumine in Streptozotocin induced experimental alzheimer disease in rats, Specialist Thesis. Gülhane Askeri Tıp Akademisi Askeri Tıp Fak. Ankara.Jayaprakasha, GK., Jagan, L., and Sakariah, K.K., 2005. Chemistry and biological activities of C. longa. Trends in Food Science & Technology;16, 533–548.Kavaklı, HŞ., Koca, C., Alıcı, O., 2011. Antioxidant effects of curcumin in spinal cord injury in rats, Turkish Journal of Trauma & Emergency Surgery, 17 (1):14-18.Khanna, NM., 1999. Turmeric – Nature’s precious gift. Curr. Sci.; 76: 1351–6.Kuhar, M., Imran, S., Singh, N., 2007. Curcumin and Quercetin Combined with Cisplatin to Induce Apoptosis in Human Laryngeal Carcinoma Hep-2 Cells through the Mitochondrial Pathway. Journal of Cancer Molecules; 3(4): 121-128.Kunnumakkara, AB., Anand, P., Aggarwal, BB., 2008. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Letters 269;199–225.Li, S., Yuan, W., Deng, G., Wang, P., Yang, P., & Aggarwal, BB., 2011. Chemical Composition and Product Quality Control of Turmeric (Curcuma longa L.). Pharmaceutical Crops; 5(1), 28-54.Maheshwari, RK., Singh, AK., 2006. Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci;78(18): 2081-7.Miquel, J., Bernd, A., Sempere, JM., Díaz-Alperi, J., Ramírez, A., 2002. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr; 34(1):37-46.Monograph; 2001. Curcuma longa . Altern Med Rev. Suppl:S62-S66. Naik, SR., Thakare, VN., Patil, SR., 2011. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property. Exp Toxicol Pathol. 63:419-31.Nazam Ansari, M., Bhandari, U., Pillai, KK., 2007. Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats. Hum Exp Toxicol. 26:933-8.Pari, L., Tewas, D., Eckel, J., 2008. Role of curcumin in health and disease. Arch Physiol Biochem;114(2):127-49.Pham-Huy, LA., He, H., Pham-Huy, C., 2008. Free Radicals, Antioxidants in Disease and Health. Int J Biomed Sci. 4(2): 89-96.Phillips, J., Moore-Medlin, T., Sonavane, K., Ekshyyan, O., McLarty, J., Nathan, CA., 2013. Curcumin Inhibits UV Radiation-Induced Skin Cancer in SKH-1 Mice. Otolaryngol Head Neck Surg. 148(5):797-803.Savcun, GY., Özkan, E., Dulundu, E., Topaloğlu, U., Sehirli, AO., Tok, OE., Ercan, F., Sharma, OP., 1976. Antioxidant activity of curcumin and related compounds. Biochemical Pharmacology, 25;1811–1812. Sharma, RA., Gescher, AJ., Steward, WP., 2005. Curcumin: the story so far. Eur J Cancer; 41(13):1955-68.Shinde, A., Ganu, J., Naik, P., 2012. Effect of free radicals & Antioxidants on oxidative stress: A Review. J Dent Allied Sci. 1(2): 63- 66.Sreejayan, Rao MN., 1994. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol; 46(12):1013-6.Şen, S., Chakraborty, R., Sridhar, C., Reddy, YSR., De, B., 2010. Free radicals, antioxidants, diseases and phytomedicines: Current status and future prospect. International Journal of Pharmaceutical Sciences and Research. 3(1): 91-100.Şener, G., Yeğen Berrak, C., 2009. İskemi Reperfüzyon Hasarı. Klinik Gelisim Dergisi; 22: 5-13. Şener, G., 2013. Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats, Ulus Travma Acil Cerrahi Derg. 19(6): 507-515.Tayyem, RF., Heath, DD., Al-Delaimy, WK., Rock, CL., 2006. Curcumin Content of Turmeric and Curry Powders. Nutrition and cancer; 55 (2): 126-31.Tewasb, D., Eckelb, J., 2008. Review Role of curcumin in health and disease. Archives of Physiology and Biochemistry, Volume 114, Issue 2, Leelavinothan Paria;127-149.Thiyagarajan, M., Sharma, SS., 2004. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci.;74:969-85.Zhao, J., Zhao, Y., Zheng, W., Lu, Y., Feng, G., Yu, S., 2008. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res.;1229:224-32.

Antioxidant effects of curcumin on the blood tissue in rats

Yıl 2019, Cilt: 7 Sayı: 1, 8 - 14, 30.06.2019
https://doi.org/10.24998/maeusabed.539891

Öz

Curcumin is a pigment found in Indian saffron
spices, also known as turmeric. The aim of this study is to investigate the
antioxidant effect of curcumin, a phytochemical, on the blood tissue of rats.
In the study, 24 Wistar rats were 8 weeks old,
randomly divided into 2 groups which were the control group and the
experimental group was fed with curcumin supplement. Curcumin supplemented group
was fed at 300mg/kg/day curcumin dissolved in corn oil by oral gavage for 12
days. 24 hours after the last feeding, TAC (Total Antioxidant Capacity) and TOC
(Total Oxidant Capacity)  were analyzed
in blood samples. In curcumin supplemented group TAC decreased significantly
than control group (p<0,05). When the TOC is examined, in curcumin
supplemented group TOC was evaluated statistically higher than in the control
group (p<0,05). Results of the study show that curcumin strengthens the
antioxidant defense system. 

Kaynakça

  • Aggarwal, B.B., 2010. Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals, Annu Rev Nutr., 21;30:173-99.Aggarwal, B.B., 2010. Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals, Annu Rev Nutr. 21;30:173-99.Aggarwal, B.B., 2013. Curcumin-free tumeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of tumeric. Mol Nutr Food Res;57,1529-42. Aggarwal, BB., Kumar, A., Bharti, AC., 2003. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Anticancer Research ; 23: 363-398.Aggarwal, BB., Sundaram, C., Malani, N., Ichikawa, H., 2007. Curcumin: The Indian solid gold. Adv Exp Med Biol; 595,1–75.Ak, T. and Gulcin, I., 2008. Antioxidant and radical scavenging properties of curcumin Chemico-Biological Interactions.;174, 27–37. Ammon, H. P. T., Anazoda, M. I., Safayhi, H., Dhawan, B. N. and Srimal R. C., 1992. Curcumin: A potent inhibitor of Leukotriene B4 formation in rat peritoneal polymorphonuclear neutrophils (PMNL), Planta Medica. 58, 26-28.Anand, P., Kunnumakkara, AB., Newman, RA., Aggarwal, BB.. 2007. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics 4: 807-818.Änderung L. Curcuma – Sechs Tipps zur richtigen Anwendung. (https://www.z entrum-der-gesundheit.de/curcuma-anwendung-ia.html). Accsess Date: 13.05.2018.Araújo, CC., Leon, LL., 2001. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz; 96(5):723-8.Aslan, R., Kutlu, R., Civi, S., Tasyurek, E., 2014. The correlation of the total antioxidant status (TAC), total oxidant status (TOC) and paraoxonase activity (PON1) with smoking. Clin Biochem; 47(6): 393-397. Auddy, B., Ferreira, M., Blasina, F., Lafon, L., Arredondo, F., Dajas, F., Tripathi, P.C., Seal, T. and Murkerjee, B., 2003. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases, Journal of Ethnopharmacology, 84, 131-138.Belviranlı, M., Okudan, N., Atalık, KEN., 2012. Effects of curcumin supplementation on oxidant/antioxidant status of heart tissue in aged rats, Genel Tıp Derg; 22(2):61-66.Delgado-Vargas, F., and Paredes-López, O., (Eds): 2003. Natural colorants for food and nutraceutical uses. CRC Press.Duan, W., Yang, Y., Yan, J., Yu, S., Liu, J., Zhou, J., et al,. 2012. The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway. Basic Res Cardiol. 107:263.Dündar, Y., Aslan, R., 1999. Hücre Moleküler Statüsünün Anlaşılması ve Fizyolojik Önem Açısından Radikaller, Antioksidanlar. İnsizyon Cerrahi Tıp Bilim Dergisi. 2(2): 134-142.Goel, A., Kunnumakkara, AB., Aggarwal, BB., 2008. Curcumin as “curecumin”: from kitchen to clinic. Biochem Pharmacol; 75(4):787- 809.Hatchera, R., Planalpb, J., Chob, F., M Tortia, Tortic, SV., 2008. Review Curcumin: From ancient medicine to current clinical trials H. Cell. Mol. Life Sci; (65), 1631 – 1652.Isik, A., 2007. The Efficiency of Curcumine in Streptozotocin induced experimental alzheimer disease in rats, Specialist Thesis. Gülhane Askeri Tıp Akademisi Askeri Tıp Fak. Ankara.Jayaprakasha, GK., Jagan, L., and Sakariah, K.K., 2005. Chemistry and biological activities of C. longa. Trends in Food Science & Technology;16, 533–548.Kavaklı, HŞ., Koca, C., Alıcı, O., 2011. Antioxidant effects of curcumin in spinal cord injury in rats, Turkish Journal of Trauma & Emergency Surgery, 17 (1):14-18.Khanna, NM., 1999. Turmeric – Nature’s precious gift. Curr. Sci.; 76: 1351–6.Kuhar, M., Imran, S., Singh, N., 2007. Curcumin and Quercetin Combined with Cisplatin to Induce Apoptosis in Human Laryngeal Carcinoma Hep-2 Cells through the Mitochondrial Pathway. Journal of Cancer Molecules; 3(4): 121-128.Kunnumakkara, AB., Anand, P., Aggarwal, BB., 2008. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Letters 269;199–225.Li, S., Yuan, W., Deng, G., Wang, P., Yang, P., & Aggarwal, BB., 2011. Chemical Composition and Product Quality Control of Turmeric (Curcuma longa L.). Pharmaceutical Crops; 5(1), 28-54.Maheshwari, RK., Singh, AK., 2006. Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci;78(18): 2081-7.Miquel, J., Bernd, A., Sempere, JM., Díaz-Alperi, J., Ramírez, A., 2002. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr; 34(1):37-46.Monograph; 2001. Curcuma longa . Altern Med Rev. Suppl:S62-S66. Naik, SR., Thakare, VN., Patil, SR., 2011. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property. Exp Toxicol Pathol. 63:419-31.Nazam Ansari, M., Bhandari, U., Pillai, KK., 2007. Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats. Hum Exp Toxicol. 26:933-8.Pari, L., Tewas, D., Eckel, J., 2008. Role of curcumin in health and disease. Arch Physiol Biochem;114(2):127-49.Pham-Huy, LA., He, H., Pham-Huy, C., 2008. Free Radicals, Antioxidants in Disease and Health. Int J Biomed Sci. 4(2): 89-96.Phillips, J., Moore-Medlin, T., Sonavane, K., Ekshyyan, O., McLarty, J., Nathan, CA., 2013. Curcumin Inhibits UV Radiation-Induced Skin Cancer in SKH-1 Mice. Otolaryngol Head Neck Surg. 148(5):797-803.Savcun, GY., Özkan, E., Dulundu, E., Topaloğlu, U., Sehirli, AO., Tok, OE., Ercan, F., Sharma, OP., 1976. Antioxidant activity of curcumin and related compounds. Biochemical Pharmacology, 25;1811–1812. Sharma, RA., Gescher, AJ., Steward, WP., 2005. Curcumin: the story so far. Eur J Cancer; 41(13):1955-68.Shinde, A., Ganu, J., Naik, P., 2012. Effect of free radicals & Antioxidants on oxidative stress: A Review. J Dent Allied Sci. 1(2): 63- 66.Sreejayan, Rao MN., 1994. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol; 46(12):1013-6.Şen, S., Chakraborty, R., Sridhar, C., Reddy, YSR., De, B., 2010. Free radicals, antioxidants, diseases and phytomedicines: Current status and future prospect. International Journal of Pharmaceutical Sciences and Research. 3(1): 91-100.Şener, G., Yeğen Berrak, C., 2009. İskemi Reperfüzyon Hasarı. Klinik Gelisim Dergisi; 22: 5-13. Şener, G., 2013. Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats, Ulus Travma Acil Cerrahi Derg. 19(6): 507-515.Tayyem, RF., Heath, DD., Al-Delaimy, WK., Rock, CL., 2006. Curcumin Content of Turmeric and Curry Powders. Nutrition and cancer; 55 (2): 126-31.Tewasb, D., Eckelb, J., 2008. Review Role of curcumin in health and disease. Archives of Physiology and Biochemistry, Volume 114, Issue 2, Leelavinothan Paria;127-149.Thiyagarajan, M., Sharma, SS., 2004. Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats. Life Sci.;74:969-85.Zhao, J., Zhao, Y., Zheng, W., Lu, Y., Feng, G., Yu, S., 2008. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res.;1229:224-32.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makalesi
Yazarlar

Şevkinaz Konak 0000-0001-6180-7586

Emine Hilal Şener 0000-0003-1303-3779

Yayımlanma Tarihi 30 Haziran 2019
Gönderilme Tarihi 14 Mart 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 7 Sayı: 1

Kaynak Göster

APA Konak, Ş., & Şener, E. H. (2019). Antioxidant effects of curcumin on the blood tissue in rats. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 7(1), 8-14. https://doi.org/10.24998/maeusabed.539891
AMA Konak Ş, Şener EH. Antioxidant effects of curcumin on the blood tissue in rats. Mehmet Akif Ersoy University Journal of Health Sciences Institute. Haziran 2019;7(1):8-14. doi:10.24998/maeusabed.539891
Chicago Konak, Şevkinaz, ve Emine Hilal Şener. “Antioxidant Effects of Curcumin on the Blood Tissue in Rats”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 7, sy. 1 (Haziran 2019): 8-14. https://doi.org/10.24998/maeusabed.539891.
EndNote Konak Ş, Şener EH (01 Haziran 2019) Antioxidant effects of curcumin on the blood tissue in rats. Mehmet Akif Ersoy University Journal of Health Sciences Institute 7 1 8–14.
IEEE Ş. Konak ve E. H. Şener, “Antioxidant effects of curcumin on the blood tissue in rats”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, c. 7, sy. 1, ss. 8–14, 2019, doi: 10.24998/maeusabed.539891.
ISNAD Konak, Şevkinaz - Şener, Emine Hilal. “Antioxidant Effects of Curcumin on the Blood Tissue in Rats”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 7/1 (Haziran 2019), 8-14. https://doi.org/10.24998/maeusabed.539891.
JAMA Konak Ş, Şener EH. Antioxidant effects of curcumin on the blood tissue in rats. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2019;7:8–14.
MLA Konak, Şevkinaz ve Emine Hilal Şener. “Antioxidant Effects of Curcumin on the Blood Tissue in Rats”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, c. 7, sy. 1, 2019, ss. 8-14, doi:10.24998/maeusabed.539891.
Vancouver Konak Ş, Şener EH. Antioxidant effects of curcumin on the blood tissue in rats. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2019;7(1):8-14.