The Effect of AGTR2 Gene A/C Polymorphism on Aerobic Endurance Performance in Female Athletes

Abstract

This study aimed to investigate the genotype and allele distributions of the AGTR2 rs11091046 A>C polymorphism in female athletes engaged in aerobic performance-based sports such as athletics and swimming. The research was conducted with a total of 50 participants: 13 athletes, 25 swimmers, and 12 sedentary individuals. DNA was extracted from blood samples, and genotyping was performed using Sanger sequencing. The results revealed that the AA genotype was significantly more prevalent among swimmers, while no significant difference was observed between athletes and sedentary individuals. Additionally, a statistically significant difference in genotype and allele distributions was found among the three groups (p<0.05). These findings suggest that endurance performance is shaped not only by genetic variants but also by environmental factors and training methodologies. The study concludes that the AGTR2 rs11091046 polymorphism may vary depending on the type of sport and proposes that genetic testing could serve as a complementary tool in personalized training planning.

Keywords

• AGTR2 gene
• genetic polymorphism
• aerobic endurance
• swimming
• athletics

Kadın Sporcularda AGTR2 Geni A/C Polimorfizminin Aerobik Dayanıklılık Performansı Üzerindeki Etkisi

Öz

Bu çalışma, AGTR2 genine ait rs11091046 A>C polimorfizminin aerobik performansa dayalı spor dallarında (atletizm ve yüzme) yer alan kadın sporculardaki genotip ve alel dağılımlarını incelemek amacıyla gerçekleştirilmiştir. Araştırma, 13 atlet, 25 yüzücü ve 12 sedanter birey olmak üzere toplam 50 katılımcı ile yürütülmüştür. Katılımcılardan alınan kan örneklerinden DNA izole edilmiş ve genotipleme işlemi Sanger dizileme yöntemi ile yapılmıştır. Yüzücülerde AA genotipinin anlamlı şekilde daha yaygın olduğunu, buna karşın atletizm sporcuları ile sedanter bireyler arasında anlamlı bir fark bulunmadığını ortaya koymuştur. Ayrıca, üç grup arasında genotip ve alel dağılımları açısından istatistiksel olarak anlamlı fark saptanmıştır (p<0.05). Bu sonuçlar, dayanıklılık performansının yalnızca genetik varyantlarla değil, aynı zamanda çevresel faktörler ve antrenman sistematiği ile şekillendiğini göstermektedir. Çalışma, AGTR2 rs11091046 polimorfizminin spor branşına bağlı olarak farklılık gösterebileceğini ve genetik analizlerin bireyselleştirilmiş antrenman planlamalarında tamamlayıcı bir unsur olabileceğini önermektedir.

Anahtar Kelimeler

• AGTR2 geni
• genetik polimorfizm
• aerobik dayanıklılık
• yüzme
• atletizm

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12. Mustafina, L. J., Naumov, V. A., Cieszczyk, P., Ahmetov, I. I., Zmijewski, P., Kostryukova, E. S., & Druzhevskaya, A. M. (2014). AGTR2 gene polymorphism is associated with muscle fibre composition, athlete status and aerobic performance. Experimental Physiology, 99(7), 1042–1052. https://doi.org/10.1113/expphysiol.2014.079335
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