Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations

Year 2025, Volume: 38 Issue: 2, 179 - 181, 30.05.2025

Serkan Özben , Berna Özcanoğlu , Mert Van , Ecem Ağdak , Aylin Yaman

https://doi.org/10.5472/marumj.1709073

https://izlik.org/JA26DA55CL

Abstract

We present a case of a 66-year-old female patient with partially compromised immunity due to diabetes mellitus, exhibiting progressive
encephalopathy characterized by balance issues, cognitive decline, and hallucinations. Magnetic resonance imaging (MRI) revealed
widespread cerebral and cerebellar atrophy, and John Cunningham virus (JCV) – DNA was detected in the cerebrospinal fluid. This
case highlights JCV encephalopathy as a potential diagnosis even in patients with partially weakened immune systems, expanding the
recognized spectrum of JCV-associated neurological conditions beyond progressive multifocal leukoencephalopathy.

Keywords

JCV encephalopathy , Progressive encephalopathy , Cerebral atrophy

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