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Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations

Year 2025, Volume: 38 Issue: 2, 179 - 181, 30.05.2025

Serkan Özben , Berna Özcanoğlu , Mert Van , Ecem Ağdak , Aylin Yaman

https://doi.org/10.5472/marumj.1709073

Abstract

We present a case of a 66-year-old female patient with partially compromised immunity due to diabetes mellitus, exhibiting progressive
encephalopathy characterized by balance issues, cognitive decline, and hallucinations. Magnetic resonance imaging (MRI) revealed
widespread cerebral and cerebellar atrophy, and John Cunningham virus (JCV) – DNA was detected in the cerebrospinal fluid. This
case highlights JCV encephalopathy as a potential diagnosis even in patients with partially weakened immune systems, expanding the
recognized spectrum of JCV-associated neurological conditions beyond progressive multifocal leukoencephalopathy.

Keywords

JCV encephalopathy Progressive encephalopathy Cerebral atrophy

References

  • Wüthrich C, Dang X, Westmoreland S, et al. Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons. Ann Neurol 2009;65:742-8. doi:10.1002/ ana.21619
  • Reoma LB, Trindade CJ, Monaco MC, et al. Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy. Ann Neurol 2019;86:878-84. doi:10.1002/ana.25608
  • Dang X, Wüthrich C, Gordon J, Sawa H, Koralnik IJ. JC virus encephalopathy is associated with a novel agnoproteindeletion JCV variant. PLoS One 2012;7: e35793. doi:10.1371/ journal.pone.0035793
  • Agnihotri SP, Wuthrich C, Dang X, et al. A fatal case of JC virus meningitis presenting with hydrocephalus in an HIVseronegative patient. Ann Neurol 2014;76:140-7. doi:10.1002/ ana.24192
  • Corbridge SM, Rice RC, Bean LA, et al. JC virus infection of meningeal and choroid plexus cells in patients with progressive multifocal leukoencephalopathy. J Neurovirol 2019;25:520-4. doi:10.1007/s13365.019.00753-y

Year 2025, Volume: 38 Issue: 2, 179 - 181, 30.05.2025

Serkan Özben , Berna Özcanoğlu , Mert Van , Ecem Ağdak , Aylin Yaman

https://doi.org/10.5472/marumj.1709073

Abstract

References

  • Wüthrich C, Dang X, Westmoreland S, et al. Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons. Ann Neurol 2009;65:742-8. doi:10.1002/ ana.21619
  • Reoma LB, Trindade CJ, Monaco MC, et al. Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy. Ann Neurol 2019;86:878-84. doi:10.1002/ana.25608
  • Dang X, Wüthrich C, Gordon J, Sawa H, Koralnik IJ. JC virus encephalopathy is associated with a novel agnoproteindeletion JCV variant. PLoS One 2012;7: e35793. doi:10.1371/ journal.pone.0035793
  • Agnihotri SP, Wuthrich C, Dang X, et al. A fatal case of JC virus meningitis presenting with hydrocephalus in an HIVseronegative patient. Ann Neurol 2014;76:140-7. doi:10.1002/ ana.24192
  • Corbridge SM, Rice RC, Bean LA, et al. JC virus infection of meningeal and choroid plexus cells in patients with progressive multifocal leukoencephalopathy. J Neurovirol 2019;25:520-4. doi:10.1007/s13365.019.00753-y
There are 5 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Case Report
Authors

Serkan Özben 0000-0002-2227-4104

Berna Özcanoğlu 0009-0009-0256-1075

Mert Van 0000-0002-9957-3735

Ecem Ağdak 0000-0002-3700-0229

Aylin Yaman 0000-0002-4364-934X

Submission Date October 30, 2024
Acceptance Date December 12, 2024
Publication Date May 30, 2025
Published in Issue Year 2025 Volume: 38 Issue: 2

Cite

APA Özben, S., Özcanoğlu, B., Van, M., … Ağdak, E. (2025). Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations. Marmara Medical Journal, 38(2), 179-181. https://doi.org/10.5472/marumj.1709073
AMA Özben S, Özcanoğlu B, Van M, Ağdak E, Yaman A. Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations. Marmara Med J. May 2025;38(2):179-181. doi:10.5472/marumj.1709073
Chicago Özben, Serkan, Berna Özcanoğlu, Mert Van, Ecem Ağdak, and Aylin Yaman. “Progressive Encephalopathy in a Patient With Diabetes Mellitus: A Case Report and Review of JCV-Related Neurological Manifestations”. Marmara Medical Journal 38, no. 2 (May 2025): 179-81. https://doi.org/10.5472/marumj.1709073.
EndNote Özben S, Özcanoğlu B, Van M, Ağdak E, Yaman A (May 1, 2025) Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations. Marmara Medical Journal 38 2 179–181.
IEEE S. Özben, B. Özcanoğlu, M. Van, E. Ağdak, and A. Yaman, “Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations”, Marmara Med J, vol. 38, no. 2, pp. 179–181, 2025, doi: 10.5472/marumj.1709073.
ISNAD Özben, Serkan et al. “Progressive Encephalopathy in a Patient With Diabetes Mellitus: A Case Report and Review of JCV-Related Neurological Manifestations”. Marmara Medical Journal 38/2 (May2025), 179-181. https://doi.org/10.5472/marumj.1709073.
JAMA Özben S, Özcanoğlu B, Van M, Ağdak E, Yaman A. Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations. Marmara Med J. 2025;38:179–181.
MLA Özben, Serkan et al. “Progressive Encephalopathy in a Patient With Diabetes Mellitus: A Case Report and Review of JCV-Related Neurological Manifestations”. Marmara Medical Journal, vol. 38, no. 2, 2025, pp. 179-81, doi:10.5472/marumj.1709073.
Vancouver Özben S, Özcanoğlu B, Van M, Ağdak E, Yaman A. Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations. Marmara Med J. 2025;38(2):179-81.