BibTex RIS Kaynak Göster

Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi

Yıl 2016, Cilt: 29 Sayı: 1, 1 - 7, 04.03.2016
https://doi.org/10.5472/MMJoa.2901.01

Öz

Amaç: Bu çalışmada sıçanlarda stres ile uyarılan mide ülserinde
simvastatin’in (SİM) olası koruyucu etkisini değerlendirmek
amaçlanmıştır.
Gereç ve Yöntem: Sprague-Dawley sıçanlarda (250-300
gr) soğuk-kısıtlama stres uygulaması ile mide ülseri oluşturuldu.
Stres öncesi 21 gün süreyle SİM (10 mg/kg/day; oral yolla) veya
fizyolojik tuzlu su (1 ml; oral yolla) uygulandı. Bir grup sıçan
21. günde SİM öncesi selektif olmayan nitrik oksit sentaz (NOS)
inhibitörü L-NAME (50 mg/kg; intraperitoneal) veya selektif
olmayan siklooksijenaz (COX) inhibitörü indometazin (İndo; 5
mg/kg; subkutan) verildi. Mideler makroskopik ve mikroskopik
olarak incelendi ve biyokimyasal analizler için saklandı.
Bulgular: Stres grubunda lezyonların şiddeti SİM ile azaldı
ancak L-NAME veya İndo ile anlamlı bir değişiklik göstermedi.
Stres mide miyeloperoksidaz aktivitesini kontrol düzeyine kıyasla
artırdı (p

Kaynakça

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Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Elif Bahadır Bu kişi benim

Elif Bahadır Bu kişi benim

Muhammet Bulut Bu kişi benim

Beyza Kabayuka Bu kişi benim

Beyza Kabayuka Bu kişi benim

Ece Söylem Şenkal Bu kişi benim

Abdullah Avlaç Bu kişi benim

Meral Yüksel Bu kişi benim

Feriha Ercan Bu kişi benim

İnci Alican

İnci Alican

Yayımlanma Tarihi 4 Mart 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 29 Sayı: 1

Kaynak Göster

APA Bahadır, E., Bahadır, E., Bulut, M., Kabayuka, B., vd. (2016). Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Medical Journal, 29(1), 1-7. https://doi.org/10.5472/MMJoa.2901.01
AMA Bahadır E, Bahadır E, Bulut M, Kabayuka B, Kabayuka B, Şenkal ES, Avlaç A, Yüksel M, Ercan F, Alican İ, Alican İ. Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Med J. Mart 2016;29(1):1-7. doi:10.5472/MMJoa.2901.01
Chicago Bahadır, Elif, Elif Bahadır, Muhammet Bulut, Beyza Kabayuka, Beyza Kabayuka, Ece Söylem Şenkal, Abdullah Avlaç, Meral Yüksel, Feriha Ercan, İnci Alican, ve İnci Alican. “Sıçanda Stres Ile uyarılan Mide ülserinde simvastatin’in Etkisi”. Marmara Medical Journal 29, sy. 1 (Mart 2016): 1-7. https://doi.org/10.5472/MMJoa.2901.01.
EndNote Bahadır E, Bahadır E, Bulut M, Kabayuka B, Kabayuka B, Şenkal ES, Avlaç A, Yüksel M, Ercan F, Alican İ, Alican İ (01 Mart 2016) Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Medical Journal 29 1 1–7.
IEEE E. Bahadır, “Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi”, Marmara Med J, c. 29, sy. 1, ss. 1–7, 2016, doi: 10.5472/MMJoa.2901.01.
ISNAD Bahadır, Elif vd. “Sıçanda Stres Ile uyarılan Mide ülserinde simvastatin’in Etkisi”. Marmara Medical Journal 29/1 (Mart 2016), 1-7. https://doi.org/10.5472/MMJoa.2901.01.
JAMA Bahadır E, Bahadır E, Bulut M, Kabayuka B, Kabayuka B, Şenkal ES, Avlaç A, Yüksel M, Ercan F, Alican İ, Alican İ. Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Med J. 2016;29:1–7.
MLA Bahadır, Elif vd. “Sıçanda Stres Ile uyarılan Mide ülserinde simvastatin’in Etkisi”. Marmara Medical Journal, c. 29, sy. 1, 2016, ss. 1-7, doi:10.5472/MMJoa.2901.01.
Vancouver Bahadır E, Bahadır E, Bulut M, Kabayuka B, Kabayuka B, Şenkal ES, Avlaç A, Yüksel M, Ercan F, Alican İ, Alican İ. Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi. Marmara Med J. 2016;29(1):1-7.