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Antinociceptive effects of morphine and physostigmine in different inbred strains of mice

Yıl 1996, Cilt: 9 Sayı: 1, 7 - 10, 01.01.1996

A.n. Aslan K. Berkman B. Çırakoğlu Ş. Oktay

Öz

Antinociceptive effects of morphine and physostigmine, alone or in combination were investigated in mice of BALB/C, C57BL/6 and CB6F1 strains. Morphine and physostigmine increased pain treshold in BALB/C and CB6F1 mice at a dose of 5 mg/kg and 0.1 mg/kg, respectively, whereas C57BL/6 mice were found to be less responsive to both agents. When a nonanalgesic dose of physostigmine (0.05 mg/kg) was combined with a nonanalgesic dose of morphine (2.5 mg/kg), a significant antinociceptive effect was observed in BALB/C and CB6F1 mice, but not in C57BL/6 strain. These results suggest that there is a significant influence of strain on cholinergic and opioid antinociception, and synergistic interaction between cholinergic and opioidergic systems also occur strain-dependently.

Anahtar Kelimeler

Analgesia tail-flick morphine physostigmine BALB/C C57BL76 CB6F1

Kaynakça

  • Mam RJ, Rnisely JS. Development of differences in the analgesia produced by the central cholinergic system. Develop Psychobiol 1986;20:345-354.

Yıl 1996, Cilt: 9 Sayı: 1, 7 - 10, 01.01.1996

A.n. Aslan K. Berkman B. Çırakoğlu Ş. Oktay

Öz

Kaynakça

  • Mam RJ, Rnisely JS. Development of differences in the analgesia produced by the central cholinergic system. Develop Psychobiol 1986;20:345-354.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Konular Klinik Tıp Bilimleri
Bölüm Derleme
Yazarlar

A.n. Aslan Bu kişi benim

K. Berkman Bu kişi benim

B. Çırakoğlu Bu kişi benim

Ş. Oktay Bu kişi benim

Yayımlanma Tarihi 1 Ocak 1996
Yayımlandığı Sayı Yıl 1996 Cilt: 9 Sayı: 1

Kaynak Göster

APA Aslan, A., Berkman, K., Çırakoğlu, B., Oktay, Ş. (1996). Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Medical Journal, 9(1), 7-10.
AMA Aslan A, Berkman K, Çırakoğlu B, Oktay Ş. Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Med J. Ocak 1996;9(1):7-10.
Chicago Aslan, A.n., K. Berkman, B. Çırakoğlu, ve Ş. Oktay. “Antinociceptive Effects of Morphine and Physostigmine in Different Inbred Strains of Mice”. Marmara Medical Journal 9, sy. 1 (Ocak 1996): 7-10.
EndNote Aslan A, Berkman K, Çırakoğlu B, Oktay Ş (01 Ocak 1996) Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Medical Journal 9 1 7–10.
IEEE A. Aslan, K. Berkman, B. Çırakoğlu, ve Ş. Oktay, “Antinociceptive effects of morphine and physostigmine in different inbred strains of mice”, Marmara Med J, c. 9, sy. 1, ss. 7–10, 1996.
ISNAD Aslan, A.n. vd. “Antinociceptive Effects of Morphine and Physostigmine in Different Inbred Strains of Mice”. Marmara Medical Journal 9/1 (Ocak 1996), 7-10.
JAMA Aslan A, Berkman K, Çırakoğlu B, Oktay Ş. Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Med J. 1996;9:7–10.
MLA Aslan, A.n. vd. “Antinociceptive Effects of Morphine and Physostigmine in Different Inbred Strains of Mice”. Marmara Medical Journal, c. 9, sy. 1, 1996, ss. 7-10.
Vancouver Aslan A, Berkman K, Çırakoğlu B, Oktay Ş. Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Med J. 1996;9(1):7-10.