FATAL CIPROFLOXACIN-INDUCED TOXIC EPIDERMAL NECROLYSIS (LYELL SYNDROME): A CASE REPORT AND REVIEW OF THE LITERATURE

Yıl 2002, Cilt: 15 Sayı: 3, 189 - 193, 03.12.2016

Cengiz Açıkel Ersin Ülkür Bahattin Çeliköz

Öz

Toxic epidermal necrolysis (TEN) is one of the most dramatic and severe adverse cutaneous drug reactions. Ciprofloxacin is a frequently prescribed fluoroquinolone and can induce TEN occasionally. A review of the English literature revealed 7 ciprofloxacin-associated TEN cases in the past 10 years. A well-documented fatal case of ciprofloxacin induced TEN is presented. This case report adds to the evidence that ciprofloxacin is associated with TEN in rare cases. All healthcare practitioners should be alert for signs of TEN in patients taking ciprofloxacin and discontinue the drug immediately. Because of the similarity of TEN to an extensive partialthickness burn besides multiorgan involvement or complications, transfer of the patient to a burn unit in the shortest time is vital.
Key Words : Toxic epidermal necrolysis, Ciprofloxacin, Quinolones, Adverse drug reactions.

Kaynakça

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