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The seasonality in the diagnosis of acute leukemia: A single center data from Turkey

Yıl 2018, Cilt: 31 Sayı: 3, 112 - 115, 31.10.2018
https://doi.org/10.5472/marumj.474176

Öz

Objectives: The seasonality in the diagnosis of acute leukemias
(ALs) has been conceived ever since and the results have been
confounding between summer and winter peaks since those times.
To our knowledge, the seasonality in the diagnosis ALs has not
been explored in our region and we aimed to investigate for a
seasonal accumulation in the diagnosis of AL patients.
Materials and Methods: A hundred and sixty-two patients
who were diagnosed with either acute myeloid leukemia (AML)
or acute lymphocytic leukemia (ALL) between November 2012
and October 2017 were included in the study. The data regarding
the gender, age, type of leukemia and the time of admission were
noted from files of the patients.
Results: The median age of the patients was 51.5 years (range,
17-85) with 64 (39.5%) female, 98 (60.5%) male. Most of AL
patients were diagnosed in August (21,13%) and the least in June
with 6 (3.7%) patients. According to the seasons; 39 (24.1%)
patients were diagnosed in winter, 40 (24.7%) patients in spring,
40 (24.7%) patients in summer and 43 (26.5%) patients in autumn
(P>0.05).
Conclusion: We could not determine any seasonality in the
diagnosis of ALs, both AML and ALL, in our study.

Kaynakça

  • 1. Fey MF, Buske C. ESMO Guidelines Working Group. Acute myeloblastic leukaemias in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24 Suppl 6:vi138-43. doi: 10.1093/annonc/ mdt320. Epub 2013 Aug 22.
  • 2. De Kouchkovsky I, Abdul-Hay M. Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J 2016 Jul 1;6:e441. doi: 10.1038/bcj.2016.50.
  • 3. Hoelzer D, Bassan R, Dombret H, Fielding A, Ribera JM, Buske C. ESMO Guidelines Committee. Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2016;27 Suppl 5:v69-v82. doi:10.1093/annonc/ mdw025 Epub 2016 Apr 7.
  • 4. Hayes DM. The seasonal incidence of acute leukemia. A contribution to the epidemiology of the disease. Cancer 1961;14:1301-5.
  • 5. Lee JA. Seasonal variation in the clinical onset of leukemia in young people. Br Med J 1962;1(5294):1737-8.
  • 6. Lee JA. Seasonal variations in the incidence of the clinical onset of leukemia. Pathol Microbiol (Basel). 1964;27:772-6.
  • 7. Allan TM.Seasonal onset of acute leukemia. Br Med J 1964;2(5409):630.
  • 8. Gunz FW, Spears GF. Distribution of acute leukaemia in time and space. Studies in New Zealand. Br Med J 1968;4(5631):604-8.
  • 9. Gao F, Nordin P, Krantz I, Chia KS, Machin D. Variation in the seasonal diagnosis of acute lymphoblastic leukemia: evidence from Singapore, the United States, and Sweden. Am J Epidemiol 2005;162:753-63. doi: 10.1093/aje/kwi272 Epub 2005 Aug 31.
  • 10. Timonen TT. A hypothesis concerning deficiency of sunlight, cold temperature, and influenza epidemics associated with the onset of acute lymphoblastic leukemia in northern Finland. Ann Hematol 1999;78:408-14.
  • 11. Eatough JP. Evidence of seasonality in the diagnosis of monocytic leukaemia. Br J Cancer 2002;87:509-10. doi: 10.1038/sj.bjc.6600497
  • 12. Calip GS, McDougall JA, Wheldon MC, Li CI, De Roos AJ. Evaluation of seasonality in the diagnosis of acute myeloid leukaemia among adults in the United States, 1992-2008. Br J Haematol 2013;160:343-50. doi: 10.1111/bjh.12137. Epub 2012 Nov 28.
  • 13. Badrinath P, Day NE, Stockton D. Seasonality in the diagnosis of acute lymphocytic leukaemia. Br J Cancer 1997;75:1711-3.
  • 14. Ross JA, Severson RK, Swensen AR, Pollock BH, Gurney JG, Robison LL. Seasonal variations in the diagnosis of childhood cancer in the United States. Br J Cancer 1999 Oct;81(3):549-53. doi: 10.1038/sj.bjc.6690729r
  • 15. Richardson RB. Promotional etiology for common childhood acute lymphoblastic leukemia: the infective lymphoid recovery hypothesis. Leuk Res 2011;35:1425-31. doi:10.1016/j.leukres.2011.07.023.
  • 16. Smith M. Considerations on a possible viral etiology for B-precursor acute lymphoblastic leukemia of childhood. J Immunother 1997;20:89-100.
  • 17. Morales-Sánchez A, Pompa-Mera EN, Fajardo-Gutiérrez A, et al. EBV, HCMV, HHV6, and HHV7 screening in bone marrow samples from children with acute lymphoblastic leukemia. Biomed Res Int 2014;2014:548097. doi: 10.1155/2014/548097.
  • 18. Kerr JR, Mattey DL. The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia. Rev Med Virol 2015;25:133-55. doi: 10.1002/rmv.1830.
  • 19. Deschler B, Lübbert M. Acute myeloid leukemia: epidemiology and etiology. Cancer 2006;107:2099-107. doi:10.1002/cncr.22233
  • 20. Gao F, Chia KS, Machin D. On the evidence for seasonal variation in the onset of acute lymphoblastic leukemia (ALL). Leuk Res 2007;31:1327-38. doi:10.1016/j. leukres.2007.03.003

Akut lösemi tanısında mevsimsel dağılım: Türkiye’den tek merkez verisi

Yıl 2018, Cilt: 31 Sayı: 3, 112 - 115, 31.10.2018
https://doi.org/10.5472/marumj.474176

Öz

Amaç: Akut lösemilerin (AL) tanısında mevsimsel değişkenlik
olabileceği uzun süredir düşünülüyor olsa da yapılan çalışmaların
sonuçları yaz ve kış pikleri arasında çelişkilidir. Bilindiği kadarıyla
bölgemizde AL tanısında mevsimsel değişkenlik incelenmemiştir.
Bu çalışmada AL hastalarının tanısında mevsimsel bir birikim olup
olmadığını araştırmayı amaçladık.
Yöntemler ve Gereçler: Kasım 2012 ile Ekim 2017 tarihleri
arasında akut myeloid lösemi (AML) veya akut lenfositik lösemi
(ALL) tanısı alan 162 hasta çalışmaya dâhil edildi. Cinsiyet, yaş,
lösemi tipi ve hastaneye yatış bilgileri hasta dosyalarından edinildi.
Bulgular: Hastaların medyan yaşı 51,5 idi (aralık: 17-85). 64
hasta (%39,5) kadın, 98’i ise (%60,5) erkekti. AL tanısı alan 21
hasta (%13) ile en sık Ağustos ayında iken, 6 hasta (%3,7) ile en
nadir Haziran ayındaydı. Mevsimlere göre incelendiğinde, 39 hasta
(%24,1) kış, 40 hasta (%24,7) ilkbahar, 40 hasta (%24,7) yaz ve 43
hasta (%26,5) ise sonbahar mevsiminde tanı almıştı (P>0,05).
Sonuç: Hem AML hem de ALL açısından bakıldığında,
çalışmamızda AL tanısında herhangi bir mevsimsel değişkenlik
belirleyemedik.

Kaynakça

  • 1. Fey MF, Buske C. ESMO Guidelines Working Group. Acute myeloblastic leukaemias in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24 Suppl 6:vi138-43. doi: 10.1093/annonc/ mdt320. Epub 2013 Aug 22.
  • 2. De Kouchkovsky I, Abdul-Hay M. Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J 2016 Jul 1;6:e441. doi: 10.1038/bcj.2016.50.
  • 3. Hoelzer D, Bassan R, Dombret H, Fielding A, Ribera JM, Buske C. ESMO Guidelines Committee. Acute lymphoblastic leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2016;27 Suppl 5:v69-v82. doi:10.1093/annonc/ mdw025 Epub 2016 Apr 7.
  • 4. Hayes DM. The seasonal incidence of acute leukemia. A contribution to the epidemiology of the disease. Cancer 1961;14:1301-5.
  • 5. Lee JA. Seasonal variation in the clinical onset of leukemia in young people. Br Med J 1962;1(5294):1737-8.
  • 6. Lee JA. Seasonal variations in the incidence of the clinical onset of leukemia. Pathol Microbiol (Basel). 1964;27:772-6.
  • 7. Allan TM.Seasonal onset of acute leukemia. Br Med J 1964;2(5409):630.
  • 8. Gunz FW, Spears GF. Distribution of acute leukaemia in time and space. Studies in New Zealand. Br Med J 1968;4(5631):604-8.
  • 9. Gao F, Nordin P, Krantz I, Chia KS, Machin D. Variation in the seasonal diagnosis of acute lymphoblastic leukemia: evidence from Singapore, the United States, and Sweden. Am J Epidemiol 2005;162:753-63. doi: 10.1093/aje/kwi272 Epub 2005 Aug 31.
  • 10. Timonen TT. A hypothesis concerning deficiency of sunlight, cold temperature, and influenza epidemics associated with the onset of acute lymphoblastic leukemia in northern Finland. Ann Hematol 1999;78:408-14.
  • 11. Eatough JP. Evidence of seasonality in the diagnosis of monocytic leukaemia. Br J Cancer 2002;87:509-10. doi: 10.1038/sj.bjc.6600497
  • 12. Calip GS, McDougall JA, Wheldon MC, Li CI, De Roos AJ. Evaluation of seasonality in the diagnosis of acute myeloid leukaemia among adults in the United States, 1992-2008. Br J Haematol 2013;160:343-50. doi: 10.1111/bjh.12137. Epub 2012 Nov 28.
  • 13. Badrinath P, Day NE, Stockton D. Seasonality in the diagnosis of acute lymphocytic leukaemia. Br J Cancer 1997;75:1711-3.
  • 14. Ross JA, Severson RK, Swensen AR, Pollock BH, Gurney JG, Robison LL. Seasonal variations in the diagnosis of childhood cancer in the United States. Br J Cancer 1999 Oct;81(3):549-53. doi: 10.1038/sj.bjc.6690729r
  • 15. Richardson RB. Promotional etiology for common childhood acute lymphoblastic leukemia: the infective lymphoid recovery hypothesis. Leuk Res 2011;35:1425-31. doi:10.1016/j.leukres.2011.07.023.
  • 16. Smith M. Considerations on a possible viral etiology for B-precursor acute lymphoblastic leukemia of childhood. J Immunother 1997;20:89-100.
  • 17. Morales-Sánchez A, Pompa-Mera EN, Fajardo-Gutiérrez A, et al. EBV, HCMV, HHV6, and HHV7 screening in bone marrow samples from children with acute lymphoblastic leukemia. Biomed Res Int 2014;2014:548097. doi: 10.1155/2014/548097.
  • 18. Kerr JR, Mattey DL. The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia. Rev Med Virol 2015;25:133-55. doi: 10.1002/rmv.1830.
  • 19. Deschler B, Lübbert M. Acute myeloid leukemia: epidemiology and etiology. Cancer 2006;107:2099-107. doi:10.1002/cncr.22233
  • 20. Gao F, Chia KS, Machin D. On the evidence for seasonal variation in the onset of acute lymphoblastic leukemia (ALL). Leuk Res 2007;31:1327-38. doi:10.1016/j. leukres.2007.03.003
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Makaleler
Yazarlar

Rafet Eren

Mehmet Hilmi Doğu Bu kişi benim

Şermin Altındal Bu kişi benim

Osman Yokuş Bu kişi benim

Elif Suyanı Bu kişi benim

Yayımlanma Tarihi 31 Ekim 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 31 Sayı: 3

Kaynak Göster

APA Eren, R., Doğu, M. H., Altındal, Ş., Yokuş, O., vd. (2018). The seasonality in the diagnosis of acute leukemia: A single center data from Turkey. Marmara Medical Journal, 31(3), 112-115. https://doi.org/10.5472/marumj.474176
AMA Eren R, Doğu MH, Altındal Ş, Yokuş O, Suyanı E. The seasonality in the diagnosis of acute leukemia: A single center data from Turkey. Marmara Med J. Ekim 2018;31(3):112-115. doi:10.5472/marumj.474176
Chicago Eren, Rafet, Mehmet Hilmi Doğu, Şermin Altındal, Osman Yokuş, ve Elif Suyanı. “The Seasonality in the Diagnosis of Acute Leukemia: A Single Center Data from Turkey”. Marmara Medical Journal 31, sy. 3 (Ekim 2018): 112-15. https://doi.org/10.5472/marumj.474176.
EndNote Eren R, Doğu MH, Altındal Ş, Yokuş O, Suyanı E (01 Ekim 2018) The seasonality in the diagnosis of acute leukemia: A single center data from Turkey. Marmara Medical Journal 31 3 112–115.
IEEE R. Eren, M. H. Doğu, Ş. Altındal, O. Yokuş, ve E. Suyanı, “The seasonality in the diagnosis of acute leukemia: A single center data from Turkey”, Marmara Med J, c. 31, sy. 3, ss. 112–115, 2018, doi: 10.5472/marumj.474176.
ISNAD Eren, Rafet vd. “The Seasonality in the Diagnosis of Acute Leukemia: A Single Center Data from Turkey”. Marmara Medical Journal 31/3 (Ekim 2018), 112-115. https://doi.org/10.5472/marumj.474176.
JAMA Eren R, Doğu MH, Altındal Ş, Yokuş O, Suyanı E. The seasonality in the diagnosis of acute leukemia: A single center data from Turkey. Marmara Med J. 2018;31:112–115.
MLA Eren, Rafet vd. “The Seasonality in the Diagnosis of Acute Leukemia: A Single Center Data from Turkey”. Marmara Medical Journal, c. 31, sy. 3, 2018, ss. 112-5, doi:10.5472/marumj.474176.
Vancouver Eren R, Doğu MH, Altındal Ş, Yokuş O, Suyanı E. The seasonality in the diagnosis of acute leukemia: A single center data from Turkey. Marmara Med J. 2018;31(3):112-5.