Yıl 2019, Cilt 32 , Sayı 3, Sayfalar 112 - 117 2019-10-31

Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid

Zekeriya Okan KARADUMAN [1] , Yucel ISTEMI [2] , Elif Gulsah BAS [3] , Kazım SOLAK [4] , Ahmet MIDI [5]


Objectives: The main purpose of this study was to determine a comparison between the chondroprotective efficacy of intra-articular

administrations of glucosamine sulphate (GS) and hyaluronic acid (HA) in the experimental knee osteoarthritis model in rats.

Materials and Methods: Forty-five rats were assigned to the following three groups: GS group (Group 1), HA group (Group 2), control

group (Group 3). The knee joints of the rats were seen macroscopically and the anterior cruciate ligaments were resected. Two weeks

after surgery, an intra-articular injection was applied to each group for three weeks with 1 week interval. In the osteoarthritic rat knee

joints, the histopathological effects of tissue regeneration of GS and HA applications were compared with the control group.

Results: The total Mankin Scale was 2.64±2.56, 3.58±3.9, 8.12±2.80 for the GS group, HA group and control group respectively.

According to these results, the GS and HA were superior to the control group. The values of the total Mankin scale, cartilage structure,

cellular abnormality, matrix staining and tidemark integrity of the GS group were lower than the values of the HA group but this

difference was not statistically significant.

Conclusion: According to the results of this study, intra-articular administration of GS for the management of osteoarthritis may be

beneficial for patients with knee osteoarthritis.

Glucosamine sulphate, Hyaluronic acid, Rat, Osteoarthritis
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Birincil Dil en
Konular Tıp
Bölüm Original Research
Yazarlar

Orcid: 0000-0002-6719-3666
Yazar: Zekeriya Okan KARADUMAN

Orcid: 0000-0002-0074-4654
Yazar: Yucel ISTEMI

Orcid: 0000-0003-0193-6495
Yazar: Elif Gulsah BAS

Orcid: 0000-0001-9320-0973
Yazar: Kazım SOLAK

Orcid: 0000-0002-6197-7654
Yazar: Ahmet MIDI (Sorumlu Yazar)

Tarihler

Yayımlanma Tarihi : 31 Ekim 2019

Bibtex @araştırma makalesi { marumj637180, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara Üniversitesi}, year = {2019}, volume = {32}, pages = {112 - 117}, doi = {10.5472/marumj.637180}, title = {Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid}, key = {cite}, author = {KARADUMAN, Zekeriya Okan and ISTEMI, Yucel and BAS, Elif Gulsah and SOLAK, Kazım and MIDI, Ahmet} }
APA KARADUMAN, Z , ISTEMI, Y , BAS, E , SOLAK, K , MIDI, A . (2019). Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Medical Journal , 32 (3) , 112-117 . DOI: 10.5472/marumj.637180
MLA KARADUMAN, Z , ISTEMI, Y , BAS, E , SOLAK, K , MIDI, A . "Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid". Marmara Medical Journal 32 (2019 ): 112-117 <https://dergipark.org.tr/tr/pub/marumj/issue/49745/637180>
Chicago KARADUMAN, Z , ISTEMI, Y , BAS, E , SOLAK, K , MIDI, A . "Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid". Marmara Medical Journal 32 (2019 ): 112-117
RIS TY - JOUR T1 - Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid AU - Zekeriya Okan KARADUMAN , Yucel ISTEMI , Elif Gulsah BAS , Kazım SOLAK , Ahmet MIDI Y1 - 2019 PY - 2019 N1 - doi: 10.5472/marumj.637180 DO - 10.5472/marumj.637180 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 112 EP - 117 VL - 32 IS - 3 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/marumj.637180 UR - https://doi.org/10.5472/marumj.637180 Y2 - 2019 ER -
EndNote %0 Marmara Medical Journal Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid %A Zekeriya Okan KARADUMAN , Yucel ISTEMI , Elif Gulsah BAS , Kazım SOLAK , Ahmet MIDI %T Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid %D 2019 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 32 %N 3 %R doi: 10.5472/marumj.637180 %U 10.5472/marumj.637180
ISNAD KARADUMAN, Zekeriya Okan , ISTEMI, Yucel , BAS, Elif Gulsah , SOLAK, Kazım , MIDI, Ahmet . "Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid". Marmara Medical Journal 32 / 3 (Ekim 2019): 112-117 . https://doi.org/10.5472/marumj.637180
AMA KARADUMAN Z , ISTEMI Y , BAS E , SOLAK K , MIDI A . Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Med J. 2019; 32(3): 112-117.
Vancouver KARADUMAN Z , ISTEMI Y , BAS E , SOLAK K , MIDI A . Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Medical Journal. 2019; 32(3): 117-112.