Determination of fosfomycin susceptibility in carbapenemaseproducing K. pneumoniae strains isolated prior to clinical use of the intravenous formulation in Turkey

Yıl 2021, Cilt: 34 Sayı: 2, 127 - 131, 31.05.2021

Gülsen Altınkanat Gelmez Barış Can Buket Erturk Sengel Volkan Korten Güner Soyletır

https://doi.org/10.5472/marumj.942784

Öz

Objectives: The incidence of infections caused by carbapenem-resistant Enterobacteriaceae has increased worldwide. Limitations
in the development of new antimicrobial agents have led clinicians to reconsider the clinical efficiency of old antibiotics, such as
intravenous formulation of fosfomycin, in the treatment of multidrug-resistant Gram-negative bacterial infections. We investigated
the fosfomycin susceptibility of carbapenemase-producing Klebsiella pneumoniae strains isolated prior to the clinical use of the
intravenous formulation of fosfomycin in Turkey.
Materials and Methods: A total of the 155 K. pneumoniae isolates which previously characterized at the molecular level for their
carbapenemase were included in this study. The minimum inhibitory concentration of fosfomycin was determined by the agar
dilution method.
Results: Overall, 65.1% of the isolates were susceptible to fosfomycin. The MIC50 and MIC90 values were 32 and 256 mg/L, respectively.
According to our results, at least two-third of carbapenemase-positive K. pneumoniae are susceptible to fosfomycin.
Conclusions: Although, the susceptibility of fosfomycin, which has just been put into the clinical use of intravenous formulation in
Turkey, is not very high, it can be considered as an alternative

Anahtar Kelimeler

Fosfomycin susceptibility, Carbapenemase-producing, Klebsiella pneumoniae

Kaynakça

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