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The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer

Yıl 2022, Cilt: 35 Sayı: 1, 94 - 99, 31.01.2022
https://doi.org/10.5472/marumj.1065820

Öz

Objective: Systemic inflammatory markers and nutritional status of the patients can be helpful both in identifying high-risk cancer
patients and in showing the prognosis of the disease. In this study we aimed to determine the effects of nutritional status and systemic
inflammatory markers on prognosis in non-small cell lung cancer.
Patients and Methods: Patients diagnosed with lung cancer between 2015 and 2019 were analyzed retrospectively. The prognostic
nutritional index (PNI), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio(NLR) were calculated and Eastern
Cooperative Oncology Group performance status (ECOG PS), and the dates of death or last follow-up were recorded. Cox regression
analysis and Kaplan-Meier curves were used to analyze the effects of parameters on survival.
Results: In the study, a total of 219 patients were analyzed. 85.4% of the patients had died. At the third step Cox regression model,
ECOG 3-4 (HR:2.18), PLR (HR:1.20) and PNI (HR:1.12) predicted the survival times. Patients with PNI>45 had a higher median
survival (495 days) than patients with PNI<45 (314 days).
Conclusion: In order to determine the prognosis of the patients at the time of diagnosis, it is recommended to use PNI and PLR values,
which can be obtained through repeated tests and evaluated at low cost, together with performance scores.

Kaynakça

  • Bunn PA. Worldwide overview of the current status of lung cancer diagnosis and treatment. Arch Pathol Lab Med 2012 ;136:1478-1 doi:10.5858/arpa.2012-0295-SA
  • Jemal A, Murray T, Ward E, et al. Cancer Statistics 2005. CA: Cancer J Clin 2005;55:10-30 doi:10.3322/canjclin.55.1.10
  • Albain KS, Crowley JJ, Leblanc M, Livingston RB. Determinants of improved outcome in small-cell lung-cancer - an analysis of the 2,580-patient Southwest Oncology Group Data-Base. J Clin Oncol 1990;8:1563-74. doi: 10.1200/Jco.1990.8.9.1563
  • Buccheri G, Ferrigno D, Tamburini M. Karnofsky and ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution. European journal of cancer. 1996;32:1135-1141
  • Hussain SP, Harris CC. Inflammation and cancer: An ancient link with novel potentials. Int J Cancer 2007;121:2373-80. doi:10.1002/ijc.23173
  • Hayat MJ, Howlader N, Reichman ME, et al. Cancer statistics, trends, and multiple primary cancer analyses from the surveillance, epidemiology, and end results (SEER) program. Oncologist 2007 ;12:20-37. doi:10.1634/theoncologist.12-1-20
  • Onodera T, Goseki N, Kosaki G. [Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients]. Nihon Geka Gakkai Zasshi 1984 Sep;85:1001-5.
  • Pinato DJ, North BV, Sharma R. A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI). Brit J Cancer 2012; 10;106:1439-45. doi:10.1038/bjc.2012.92
  • Nozoe T, Kimura Y, Ishida M, et al. Correlation of pre-operative nutritional condition with post-operative complications in surgical treatment for oesophageal carcinoma. Eur J Surg Oncol 2002;28:396-400. doi:10.1053/ejso.2002.1257
  • Tokunaga R, Sakamoto Y, Nakagawa S, et al. Prognostic nutritional index predicts severe complications, recurrence, and poor prognosis in patients with colorectal cancer undergoing primary tumor resection. Dis Colon Rectum 2015;58:1048-57. doi:10.1097/Dcr.0000000000000458
  • Mohri T, Mohri Y, Shigemori T, et al. Impact of prognostic nutritional index on long-term outcomes in patients with breast cancer. World J Surg Oncol.2016 ;14:170. doi:ARTN 17010.1186/s12957-016-0920-7
  • Yasar HA, Bir Yucel K, Arslan C, et al. The relationship between prognostic nutritional index and treatment response in patients with metastatic renal cell cancer. J Oncol Pharm Pract 2019;26:1110-6. doi:10.1177/1078155219883004
  • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565-70. doi:10.1126/science.1203486
  • Zhang J, Huang SH, Li H, et al. Preoperative lymphocyte count is a favorable prognostic factor of disease-free survival in non-small-cell lung cancer. Med Oncol 2013 ;30:352 doi:ARTN 35210.1007/s12032-012-0352-3
  • Schmidt H, Bastholt L, Geertsen P, et al. Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Brit J Cancer 2005;93:273-8. doi:10.1038/sj.bjc.6602702
  • Atzpodien J, Royston P, Wandert T, et al. Metastatic renal carcinoma comprehensive prognostic system. Brit J Cancer 2003;88:348-53. doi:10.1038/sj.bjc.6600768
  • Fogar P, Sperti C, Basso D, et al. Decreased total lymphocyte counts in pancreatic cancer: An index of adverse outcome. Pancreas 2006;32:22-8. doi: 10.1097/01.mpa.0000188305.90290.50
  • Cedres S, Torrejon D, Martinez A, et al. Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer. Clin Transl Oncol 2012;14:864-9. doi:10.1007/s12094-012-0872-5
  • Brown KM, Domin C, Aranha GV, et al. Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. Am J Surg 2005;189:278-2. doi:10.1016/j.amjsurg.2004.11.014
  • Kwon HC, Kim SH, Oh SY, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers 2012;17:216-22. doi:10.3109/1354750x.2012.656705
  • Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982;5:649-56.
  • Gridelli C, Ardizzoni A, Le Chevalier T, et al. Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: results of an European Experts Panel. Ann Oncol 2004;15:419-26
  • Hong X, Cui BH, Wang M, et al. Systemic Immune-inflammation Index, based on Platelet Counts and Neutrophil-Lymphocyte Ratio, is useful for predicting prognosis in small cell lung cancer. Tohoku J Exp Med 2015 ;236:297-304. doi:10.1620/tjem.236.297
  • Ceze N, Thibault G, Goujon G, et al. Pre-treatment lymphopenia as a prognostic biomarker in colorectal cancer patients receiving chemotherapy. Cancer Chemoth Pharm 2011;68:1305-13. doi:10.1007/s00280-011-1610-3
  • Ray-Coquard I, Cropet C, Van Glabbeke M, et al. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res 2009;69:5383-91. doi:10.1158/0008-5472.Can-08-3845
  • Eatrides J, Thompson Z, Lee JH, et al. Serum albumin as a stable predictor of prognosis during initial treatment in patients with diffuse large B cell lymphoma. Ann Hematol 2015 ;94:357-8. doi:10.1007/s00277-014-2150-9
  • Wang ZT, Wang YJ, Zhang XM, et al. Pretreatment prognostic nutritional index as a prognostic factor in lung cancer: Review and meta-analysis. Clin Chim Acta 2018;486:303-10. doi:10.1016/j.cca.2018.08.030
  • Bekmez E. Küçük hücreli akciğer kanserinde prognostik nutrisyonel indeksin prognoz üzerine etkisi: Tek merkez deneyimi. Namık Kemal Tıp Dergisi 2020;8:158-162.
  • Foster NR, Mandrekar SJ, Schild SE, et al. Prognostic factors differ by tumor stage for small cell lung cancer a pooled analysis of North Central Cancer Treatment Group Trials. Cancer-Am Cancer Soc 2009 15;115:2721-31. doi:10.1002/cncr.24314
  • Johnson DH, Turrisi AT, Chang AY, et al. Alternating chemotherapy and twice-daily thoracic radiotherapy in limited-stage small-cell lung-cancer - a pilot-study of the Eastern Cooperative Oncology Group. J Clin Oncol 1993;11:879-84. doi:10.1200/Jco.1993.11.5.879
  • Torun E, Fidan A, Çağlayan B, et al. Küçük hücreli akciğer kanserinde prognostik faktörler. Tüberküloz ve Toraks Dergisi 2008;56:22-9.
  • Gu XB, Sun SQ, Gao XS, et al. Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: evidence from 3,430 patients. Sci Rep-Uk. 2016;6:23893. doi: doi: 10.1038/srep23893
  • Xie D, Marks R, Zhang MR, et al. Nomograms predict overall survival for patients with small-cell lung cancer incorporating pretreatment peripheral blood markers. J Thorac Oncol 2015;10:1213-20. doi:10.1097/Jto.0000000000000585
  • Wu GN, Yao YW, Bai CQ, et al. Combination of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio is a useful prognostic factor in advanced non-small cell lung cancer patients. Thorac Cancer 2015;6:275-87. doi:10.1111/1759-7714.12178
  • Öztürk AE, Kömürcüoğlu B, Karakurt G, et al. İleri evre akciğer kanserinde; Yaygın Kanser İnflamasyon İndeksi (ALI), serum nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranının (PLR) prognostik değeri. Journal of Izmir Chest Hospital 2021;35:134-9. doi:10.5222/igh.2021.83007
Yıl 2022, Cilt: 35 Sayı: 1, 94 - 99, 31.01.2022
https://doi.org/10.5472/marumj.1065820

Öz

Kaynakça

  • Bunn PA. Worldwide overview of the current status of lung cancer diagnosis and treatment. Arch Pathol Lab Med 2012 ;136:1478-1 doi:10.5858/arpa.2012-0295-SA
  • Jemal A, Murray T, Ward E, et al. Cancer Statistics 2005. CA: Cancer J Clin 2005;55:10-30 doi:10.3322/canjclin.55.1.10
  • Albain KS, Crowley JJ, Leblanc M, Livingston RB. Determinants of improved outcome in small-cell lung-cancer - an analysis of the 2,580-patient Southwest Oncology Group Data-Base. J Clin Oncol 1990;8:1563-74. doi: 10.1200/Jco.1990.8.9.1563
  • Buccheri G, Ferrigno D, Tamburini M. Karnofsky and ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution. European journal of cancer. 1996;32:1135-1141
  • Hussain SP, Harris CC. Inflammation and cancer: An ancient link with novel potentials. Int J Cancer 2007;121:2373-80. doi:10.1002/ijc.23173
  • Hayat MJ, Howlader N, Reichman ME, et al. Cancer statistics, trends, and multiple primary cancer analyses from the surveillance, epidemiology, and end results (SEER) program. Oncologist 2007 ;12:20-37. doi:10.1634/theoncologist.12-1-20
  • Onodera T, Goseki N, Kosaki G. [Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients]. Nihon Geka Gakkai Zasshi 1984 Sep;85:1001-5.
  • Pinato DJ, North BV, Sharma R. A novel, externally validated inflammation-based prognostic algorithm in hepatocellular carcinoma: the prognostic nutritional index (PNI). Brit J Cancer 2012; 10;106:1439-45. doi:10.1038/bjc.2012.92
  • Nozoe T, Kimura Y, Ishida M, et al. Correlation of pre-operative nutritional condition with post-operative complications in surgical treatment for oesophageal carcinoma. Eur J Surg Oncol 2002;28:396-400. doi:10.1053/ejso.2002.1257
  • Tokunaga R, Sakamoto Y, Nakagawa S, et al. Prognostic nutritional index predicts severe complications, recurrence, and poor prognosis in patients with colorectal cancer undergoing primary tumor resection. Dis Colon Rectum 2015;58:1048-57. doi:10.1097/Dcr.0000000000000458
  • Mohri T, Mohri Y, Shigemori T, et al. Impact of prognostic nutritional index on long-term outcomes in patients with breast cancer. World J Surg Oncol.2016 ;14:170. doi:ARTN 17010.1186/s12957-016-0920-7
  • Yasar HA, Bir Yucel K, Arslan C, et al. The relationship between prognostic nutritional index and treatment response in patients with metastatic renal cell cancer. J Oncol Pharm Pract 2019;26:1110-6. doi:10.1177/1078155219883004
  • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565-70. doi:10.1126/science.1203486
  • Zhang J, Huang SH, Li H, et al. Preoperative lymphocyte count is a favorable prognostic factor of disease-free survival in non-small-cell lung cancer. Med Oncol 2013 ;30:352 doi:ARTN 35210.1007/s12032-012-0352-3
  • Schmidt H, Bastholt L, Geertsen P, et al. Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Brit J Cancer 2005;93:273-8. doi:10.1038/sj.bjc.6602702
  • Atzpodien J, Royston P, Wandert T, et al. Metastatic renal carcinoma comprehensive prognostic system. Brit J Cancer 2003;88:348-53. doi:10.1038/sj.bjc.6600768
  • Fogar P, Sperti C, Basso D, et al. Decreased total lymphocyte counts in pancreatic cancer: An index of adverse outcome. Pancreas 2006;32:22-8. doi: 10.1097/01.mpa.0000188305.90290.50
  • Cedres S, Torrejon D, Martinez A, et al. Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer. Clin Transl Oncol 2012;14:864-9. doi:10.1007/s12094-012-0872-5
  • Brown KM, Domin C, Aranha GV, et al. Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. Am J Surg 2005;189:278-2. doi:10.1016/j.amjsurg.2004.11.014
  • Kwon HC, Kim SH, Oh SY, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers 2012;17:216-22. doi:10.3109/1354750x.2012.656705
  • Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982;5:649-56.
  • Gridelli C, Ardizzoni A, Le Chevalier T, et al. Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: results of an European Experts Panel. Ann Oncol 2004;15:419-26
  • Hong X, Cui BH, Wang M, et al. Systemic Immune-inflammation Index, based on Platelet Counts and Neutrophil-Lymphocyte Ratio, is useful for predicting prognosis in small cell lung cancer. Tohoku J Exp Med 2015 ;236:297-304. doi:10.1620/tjem.236.297
  • Ceze N, Thibault G, Goujon G, et al. Pre-treatment lymphopenia as a prognostic biomarker in colorectal cancer patients receiving chemotherapy. Cancer Chemoth Pharm 2011;68:1305-13. doi:10.1007/s00280-011-1610-3
  • Ray-Coquard I, Cropet C, Van Glabbeke M, et al. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res 2009;69:5383-91. doi:10.1158/0008-5472.Can-08-3845
  • Eatrides J, Thompson Z, Lee JH, et al. Serum albumin as a stable predictor of prognosis during initial treatment in patients with diffuse large B cell lymphoma. Ann Hematol 2015 ;94:357-8. doi:10.1007/s00277-014-2150-9
  • Wang ZT, Wang YJ, Zhang XM, et al. Pretreatment prognostic nutritional index as a prognostic factor in lung cancer: Review and meta-analysis. Clin Chim Acta 2018;486:303-10. doi:10.1016/j.cca.2018.08.030
  • Bekmez E. Küçük hücreli akciğer kanserinde prognostik nutrisyonel indeksin prognoz üzerine etkisi: Tek merkez deneyimi. Namık Kemal Tıp Dergisi 2020;8:158-162.
  • Foster NR, Mandrekar SJ, Schild SE, et al. Prognostic factors differ by tumor stage for small cell lung cancer a pooled analysis of North Central Cancer Treatment Group Trials. Cancer-Am Cancer Soc 2009 15;115:2721-31. doi:10.1002/cncr.24314
  • Johnson DH, Turrisi AT, Chang AY, et al. Alternating chemotherapy and twice-daily thoracic radiotherapy in limited-stage small-cell lung-cancer - a pilot-study of the Eastern Cooperative Oncology Group. J Clin Oncol 1993;11:879-84. doi:10.1200/Jco.1993.11.5.879
  • Torun E, Fidan A, Çağlayan B, et al. Küçük hücreli akciğer kanserinde prognostik faktörler. Tüberküloz ve Toraks Dergisi 2008;56:22-9.
  • Gu XB, Sun SQ, Gao XS, et al. Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: evidence from 3,430 patients. Sci Rep-Uk. 2016;6:23893. doi: doi: 10.1038/srep23893
  • Xie D, Marks R, Zhang MR, et al. Nomograms predict overall survival for patients with small-cell lung cancer incorporating pretreatment peripheral blood markers. J Thorac Oncol 2015;10:1213-20. doi:10.1097/Jto.0000000000000585
  • Wu GN, Yao YW, Bai CQ, et al. Combination of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio is a useful prognostic factor in advanced non-small cell lung cancer patients. Thorac Cancer 2015;6:275-87. doi:10.1111/1759-7714.12178
  • Öztürk AE, Kömürcüoğlu B, Karakurt G, et al. İleri evre akciğer kanserinde; Yaygın Kanser İnflamasyon İndeksi (ALI), serum nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranının (PLR) prognostik değeri. Journal of Izmir Chest Hospital 2021;35:134-9. doi:10.5222/igh.2021.83007
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Original Research
Yazarlar

Tibel Tuna Bu kişi benim 0000-0003-4386-8259

Yasemin Kemal Bu kişi benim 0000-0002-1175-9085

Yusuf Taha Gullu Bu kişi benim 0000-0001-8165-234X

Nurhan Koksal Bu kişi benim 0000-0001-9833-0304

Selen Ala Bu kişi benim 0000-0001-9070-9950

Yayımlanma Tarihi 31 Ocak 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 35 Sayı: 1

Kaynak Göster

APA Tuna, T., Kemal, Y., Gullu, Y. T., Koksal, N., vd. (2022). The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer. Marmara Medical Journal, 35(1), 94-99. https://doi.org/10.5472/marumj.1065820
AMA Tuna T, Kemal Y, Gullu YT, Koksal N, Ala S. The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer. Marmara Med J. Ocak 2022;35(1):94-99. doi:10.5472/marumj.1065820
Chicago Tuna, Tibel, Yasemin Kemal, Yusuf Taha Gullu, Nurhan Koksal, ve Selen Ala. “The Effect of Performance Score, Prognostic Nutritional Index, Serum Neutrophil-to-Lymphocyte Ratio, and Thrombocyte-to-Lymphocyte Ratio on Prognosis in Non-Small Cell Lung Cancer”. Marmara Medical Journal 35, sy. 1 (Ocak 2022): 94-99. https://doi.org/10.5472/marumj.1065820.
EndNote Tuna T, Kemal Y, Gullu YT, Koksal N, Ala S (01 Ocak 2022) The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer. Marmara Medical Journal 35 1 94–99.
IEEE T. Tuna, Y. Kemal, Y. T. Gullu, N. Koksal, ve S. Ala, “The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer”, Marmara Med J, c. 35, sy. 1, ss. 94–99, 2022, doi: 10.5472/marumj.1065820.
ISNAD Tuna, Tibel vd. “The Effect of Performance Score, Prognostic Nutritional Index, Serum Neutrophil-to-Lymphocyte Ratio, and Thrombocyte-to-Lymphocyte Ratio on Prognosis in Non-Small Cell Lung Cancer”. Marmara Medical Journal 35/1 (Ocak 2022), 94-99. https://doi.org/10.5472/marumj.1065820.
JAMA Tuna T, Kemal Y, Gullu YT, Koksal N, Ala S. The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer. Marmara Med J. 2022;35:94–99.
MLA Tuna, Tibel vd. “The Effect of Performance Score, Prognostic Nutritional Index, Serum Neutrophil-to-Lymphocyte Ratio, and Thrombocyte-to-Lymphocyte Ratio on Prognosis in Non-Small Cell Lung Cancer”. Marmara Medical Journal, c. 35, sy. 1, 2022, ss. 94-99, doi:10.5472/marumj.1065820.
Vancouver Tuna T, Kemal Y, Gullu YT, Koksal N, Ala S. The effect of performance score, prognostic nutritional index, serum neutrophil-to-lymphocyte ratio, and thrombocyte-to-lymphocyte ratio on prognosis in non-small cell lung cancer. Marmara Med J. 2022;35(1):94-9.