The alterations of blood-testis barrier in experimental testicular injury models

Yıl 2022, Cilt: 35 Sayı: 2, 249 - 253, 30.05.2022

Feriha Ercan Merve Acıkel Elmas

https://doi.org/10.5472/marumj.1114971

Cited By: 1

Öz

The blood-testis barrier is found between the Sertoli cells and divides the seminiferous tubule epithelium into basal and adluminal
compartments. The germinal cell renewal, differentiation and cell cycle progression up to the preleptotene spermatocytes stage
take place in the basal compartment, however, meiosis, spermiogenesis and spermiation take place in the adluminal compertment.
The blood-testis barrier consists of tight junctions as well as ectoplasmic specialisations, desmosomes and gap junctions to create
specific microenvironment for the completion of spermatogenesis to form spermatozoa. The blood-testis barrier is not a static
ultrastructure, it undergoes extensive restructuring during the seminiferous tubule epithelial cycle of spermatogenesis to allow the
transit of preleptotene spermotocytes at the blood-testis barrier from basal compartment towards the adluminal compartment.
The functions of the blood-testis barrier include preventing the transport of biomolecules into the paracellular space, forming an
immunological barrier, separating cellular processes during the spermatogenic epithelial cycle, and establishing the cellular polarity
of the seminiferous tubule. However, various environmental conditions, chemotherapeutic agents, toxic substances and lifestyle have
degenerative effects on blood-testis barrier, resulting in testicular damage, altered sperm parameters and ultimately male infertility.
The alterations in morphological and molecular organization of blood-testis barrier in different experimentally induced testis injury
models are reviewed in this article.

Anahtar Kelimeler

Blood-testis barrier, Sertoli cells, Tight junction, Testicular injury models

Kaynakça

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