A case of granulomatosis of polyangiitis presenting with COVID-19 infection: False-positivity or co-existence?

Year 2023, Volume: 36 Issue: 3, 373 - 376, 29.09.2023

Mehtap Kaya Ibrahim Gokce Sercin Guven Serim Pul Harika Alpay

https://doi.org/10.5472/marumj.1368360

Abstract

Coronavirus disease 2019 (COVID-19) was declared a global pandemic and a public health emergency worldwide in March 2020.
COVID-19 presents with non-specific symptoms of the upper airway and pulmonary system, which can overlap with other diseases
involving the respiratory system as granulomatosis with polyangiitis (GPA). Both diseases have high morbidity and mortality rates
and it is important to promptly differentiate and treat them. Real-time reverse transcriptase polymerase chain reaction (RT-PCR)
is currently the recommended method for diagnosing COVID-19. Antibody-based tests are used to diagnose both pat and current
COVID-19 infections.
We present a previously healthy thirteen-year-old girl who was admitted with upper airway symptoms and pulmonary involvement,
and progressed to acute kidney failure. Laboratory findings showed leukocytosis, anemia, elevated kidney function tests and 2+
proteinuria. Computed tomography (CT) of the lungs showed multiple nodules, cavities, and ground-glass opacities (GGOs). We
performed RT-PCR tests for COVID-19 for three times. Results were all negative, but the COVID-19 immunoglobulin (Ig)M test
sent simultaneously was positive. Based on the cytoplasmic antineutrophilic cytoplasmic antibody (c-ANCA) positivity, upper airway,
pulmonary, and renal involvement, she was diagnosed as GPA.
This report highlights that COVID-19 antibody tests can be false-positive in patients with autoimmune diseases including GPA.

Keywords

COVID-19, Granulomatosis with polyangiitis, False-positive antibody test

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