Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac

Yıl 2017, Cilt: 21 Sayı: 4, 771 - 782, 01.12.2017

Kailas Krishnat Malı Shashikant C Dhawale Remeth J Dıas Vijay D Havaldar Pankaj R Kavıtake

Öz

The aim of present investigation was to characterize

carboxymethyl tamarind gum (CMTG) based interpenetrating

networks (IPNs) of aceclofenac for site specific sustained delivery.

The drug loaded IPNs were prepared by using chitosan and

CMTG as polymers and gluteraldehyde as crosslinking agent.

The IPNs were characterized by Attenuated total reflectance-

Fourier transform infrared (ATR-FTIR) spectroscopy, thermal

analysis, X-ray powder diffraction and solid state 13C-nuclear

magnetic resonance spectroscopy. The prepared IPNs were

evaluated for the drug entrapment efficiency and equilibrium

swelling. The drug release from IPNs was studied in 0.1NHCl

for 2h followed by phosphate buffer pH 6.8 for further 10h and

compared with commercial tablet. The results of ATR-FTIR

and thermal analysis for blank IPNs indicated intercalation

of polymeric chains of crosslinked CMTG and chitosan.

The results of solid state characterization revealed that the

aceclofenac is compatible with IPNs. Entrapment efficiency of

IPNs was found to be increased with increase in crosslinker

concentration as well as amount of CMTG. The equilibrium

swelling study indicated pH dependent swelling of IPNs. The

drug release by IPNs showed sustained release of aceclofenac

upto 12h while commercial formulation showed fast release

within 8h. From the results, it can be concluded that the IPNs

of CMTG and chitosan has potential in development of site

specific sustained drug delivery.

Anahtar Kelimeler

Interpenetrating networks, carboxymethyl tamarind gum, chitosan, aceclofenac, crosslinking

Kaynakça

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