Bilateral Arteria Carotis Communis Ligasyonu Sonrası Arteria Basilaris’te Gözüken Morfohistopatolojik Değişikliklere Cinsiyetin Etkisi: Deneysel Çalışma

Yıl 2020, Cilt: 2 Sayı: 2, 28 - 33, 28.07.2020

Cengiz Öztürk , Kemal Alp Nalcı , Onur Ceylan , İsmail Malkoç , Mehmet Aydin

https://doi.org/10.37990/medr.760505

Öz

incelmesi, uzama, kıvrılma, vasküler remodelizasyon ve anevrizmalara sebep olabilir. Biz cinsiyetin bilateral arteria carotis communis
ligasyonu sonucu oluşan histomorfolojik değişikliklerin derecesine olan etkisini araştırdık.
Materyal ve Metot: Bu çalışma 7 dişi ve 7 erkek tavşan üzerinde yapılmıştır. Hem erkek hem de dişi tavşanlardan ikisi kontrol, diğerleriyse
deney grubu olarak kullanıldı. Arteria carotis communis bifurkasyonunun hemen proksimalinden uygulanan kalıcı ligasyon, steno-oklüziv
karotis arter hastalığını tekrarlamak için yapıldı. Hayvanlar üzerinde yapılan bu çalışmanın 3. haftasında baziler arter hacmi stereolojik
yöntemlerle ölçüldü. Sonuçlar Mann-Whitney U testi ile karşılaştırıldı.
Bulgular: Baziler arterlerde büyük oranda luminal genişleme, duvar incelmesi, uzaması, kıvrılması ve doligoektatik kümelenme tespit edildi.
Baziler arterlerin ortalama hacmi erkek kontrol grubu tavşanlarında 3,65 ± 0,35 mm3, erkek deney tavşanlarında ise 4.96 ± 0.99 mm3 olarak
değerlendirildi. Baziler arterlerin ortalama hacim değerleri dişi kontrol grubu tavşanlarında 3,97 ± 0,40 mm3, dişi deney tavşanlarında ise
6,32 ± 1,13 mm3 olduğu tespit edildi. Baziler arter genişlemesi dişi tavşanlarda erkeklerden gözle görülür derecede belirgindi (p<0.01).
Sonuç: Bilateral arteria carotis communis ligasyonu, dişi tavşanlarda erkek tavşanlara göre daha belirgin luminal genişleme, duvar
incelmesi, uzama, kıvrılma ve anevrizmalara sebep oluyor.

Anahtar Kelimeler

Bilateral arteria carotis communis ligasyonu, baziler arterler, stereolojik yöntem

Effect of Gender on Morphohistopathological changes of Basilar Arteries Following Bilateral Common Carotid artery Ligation: An Experimental Study

Öz

Aim: Steno-occlusive carotid artery disease causes increased pressure, retrograde blood flow, luminal enlargement, vascular wall
thinning, elongation, convolutions, vascular re-modelization, and aneurysm formation in basilar arteries. We investigated if gender affects
the severity of histomorphologic alterations of basilar arteries after bilateral common carotid artery ligation.
Material and Methods: This study was conducted on 7 male and 7 female rabbits. Two of both male and female rabbits were used as a
control group and the remaining were used as the study group. Permanent ligation of the common carotid arteries from just proximal of
bifurcation was performed to replicate steno-occlusive carotid artery disease. Basilar artery volumes were measured by stereological
methods after the sacrifice of the animals at the end of the 3rd week. Results were compared Mann-Witney U test between groups.
Results: Luminal enlargement, wall thinning, elongation, convolutions, and doligoectatic configurations were detected in the majority of
basilar arteries. The mean basilar arterial volume values were estimated as male rabbits were 3.65 ± 0.35 mm3 in control and 4.96 ± 0.99
mm3 in the study group. The mean basilar arterial volume values were estimated as female rabbits were 3.97 ± 0.40 mm3 in control and
6.32 ± 1.13 mm3 in the study group. The severity of basilar enlargement was significantly higher in the female rabbits compared with the
male rabbits (p < 0.01).
Conclusion: Bilateral common carotid artery ligation causes more severe luminal enlargement, wall thinning, elongation, convolution, and
aneurysm formation in female rabbits than males.
Keywords: Bilateral common carotid artery ligation (BCCAL), basilar artery (BA), stereological method

Anahtar Kelimeler

common carotid ligation,, basilar arteries, stereological method

Kaynakça

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