Disseminated occult bone metastasis as shown by 18F Na-F Positron Emission Tomography-Computed Tomography: Diagnostic Challenge
Abstract
46 years old woman with diagnosis of breast carcinoma who had disseminated bone metastasis invisible in bone scingtraphy SPECT and 18F fluorodeoxyglucose PET-CT. The 18F Na-F PET-CT imaging demonstrated uptake related to the metastasis.
Keywords
References
- 1. Jadvar, H., Desai, B., Ji, L., Conti, P. S., Dorff, T. B., Groshen, S. G., Gross, M. E., Pinski, J. K., & Quinn, D. I. (2012). Prospective evaluation of 18F-NaF and 18F-FDG PET/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer. Clinical nuclear medicine, 37(7), 637–643. https://doi.org/10.1097/RLU.0b013e318252d829
- 2. Zhu, Y., Chen, Y., Huang, Z., & Liu, L. (2017). Unsuspected Metastatic Ovarian Cancer Revealed by 18F-NaF PET/CT Performed to Evaluate Lower-Back Pain. Clinical nuclear medicine, 42(2), 154–156. https://doi.org/10.1097/RLU.0000000000001483
- 3. Araz, M., Aras, G., & Küçük, Ö. N. (2015). The role of 18F-NaF PET/CT in metastatic bone disease. Journal of bone oncology, 4(3), 92–97. https://doi.org/10.1016/j.jbo.2015.08.002
- 4. Sampath, S. C., Sampath, S. C., Mosci, C., Lutz, A. M., Willmann, J. K., Mittra, E. S., Gambhir, S. S., & Iagaru, A. (2015). Detection of osseous metastasis by 18F-NaF/18F-FDG PET/CT versus CT alone. Clinical nuclear medicine, 40(3), e173–e177. https://doi.org/10.1097/RLU.0000000000000560
- 5. Iagaru, A., Mittra, E., Dick, D. W., & Gambhir, S. S. (2012). Prospective evaluation of (99m)Tc MDP scintigraphy, (18)F NaF PET/CT, and (18)F FDG PET/CT for detection of skeletal metastases. Molecular imaging and biology, 14(2), 252–259. https://doi.org/10.1007/s11307-011-0486-2
- 6. Broos, W. A. M., van der Zant, F. M., Wondergem, M., & Knol, R. J. J. (2018). Accuracy of 18F-NaF PET/CT in bone metastasis detection and its effect on patient management in patients with breast carcinoma. Nuclear medicine communications, 39(4), 325–333. https://doi.org/10.1097/MNM.0000000000000807
Details
Primary Language
English
Subjects
Nuclear Medicine
Journal Section
Case Report
Authors
Zehra Pınar Koç
*
0000-0002-3274-5790
Türkiye
Pınar Pelin Özcan
0000-0003-0147-2678
Türkiye
Ali İnal
0000-0001-9510-9858
Türkiye
Publication Date
April 30, 2026
Submission Date
April 7, 2026
Acceptance Date
April 15, 2026
Published in Issue
Year 2026 Volume: 6 Number: 1