Case Report

Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings

Volume: 6 Number: 2 July 30, 2026

Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings

Abstract

Primary laryngeal lymphoma is an extremely rare extranodal manifestation of non-Hodgkin lymphoma, accounting for less than 1% of all laryngeal neoplasms. We report a case of isolated primary B-cell lymphoma of the larynx evaluated with 18F-FDG PET/CT imaging. PET/CT demonstrated intense FDG uptake (SUVmax: 16.3) in the laryngeal lesion, while mild FDG uptake (SUVmax: 5.5) was observed in the right palatine tonsil, likely of inflammatory origin. The patient underwent R-CHOP therapy, and both interim and post-treatment PET/CT scans showed complete metabolic and anatomic response. This case highlights the critical role of 18F-FDG PET/CT in the staging and management of rare primary laryngeal lymphomas.

Keywords

References

  1. 1. Vannata, B., & Zucca, E. (2015). Primary extranodal B-cell lymphoma: current concepts and treatment strategies. Chinese clinical oncology, 4(1), 10. https://doi.org/10.3978/j.issn.2304-3865.2014.12.01
  2. 2. Vega, F., Lin, P., & Medeiros, L. J. (2005). Extranodal lymphomas of the head and neck. Annals of diagnostic pathology, 9(6), 340–350. https://doi.org/10.1016/j.anndiagpath.2005.09.020
  3. 3. Markou, K., Goudakos, J., Constantinidis, J., Kostopoulos, I., Vital, V., & Nikolaou, A. (2010). Primary laryngeal lymphoma: report of 3 cases and review of the literature. Head & neck, 32(4), 541–549. https://doi.org/10.1002/hed.21104
  4. 4. S, H., Sudarsan, S. S., Anbarasan, S., & Sankar, S. (2024). Unusual Presentation of Non-Hodgkin Lymphoma of Two Cases: Case Report. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 76(4), 3717–3721. https://doi.org/10.1007/s12070-024-04719-3
  5. 5. Cavalot, A. L., Preti, G., Vione, N., Nazionale, G., Palonta, F., & Fadda, G. L. (2001). Isolated primary non-Hodgkin's malignant lymphoma of the larynx. The Journal of laryngology and otology, 115(4), 324–326. https://doi.org/10.1258/0022215011907325
  6. 6. Issa CP, Nunez A, Mualla R, et al. Imaging of extranodal lymphomas in the head and neck: case series. Case Rep Clin Radiol. 2024;2:72–80.
  7. 7. Arslan, E., Nişli, S., Baydemir, İ., Yilmaz Bildik, B., Tosunoglu, Z., Şahin, Ö. F., Öztürk, A. E., Alçin, G., Akgün, E., Yokuş, O., Erdem Huq, G., & Çermik, T. F. (2026). Diagnostic and prognostic importance of 18 F-fluorodeoxyglucose PET/computed tomography in primary extranodal and atypically presenting lymphomas. Nuclear medicine communications, 47(3), 335–343. https://doi.org/10.1097/MNM.0000000000002096
  8. 8. Coşkun, Ç., Kurucu, N., Kutluk, T., Yılmaz, T., Bulut, E., & Üner, A. (2025). Primary B-cell non-Hodgkin lymphoma of the larynx in children: report of two cases and a review of the literature. The Turkish journal of pediatrics, 67(5), 765–771. https://doi.org/10.24953/turkjpediatr.2025.6042

Details

Primary Language

English

Subjects

Nuclear Medicine

Journal Section

Case Report

Publication Date

July 30, 2026

Submission Date

April 21, 2026

Acceptance Date

June 20, 2026

Published in Issue

Year 2026 Volume: 6 Number: 2

APA
Tosunoğlu, Z., & Şahin, Ö. F. (2026). Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings. Molecular Oncologic Imaging, 6(2). https://doi.org/10.71286/moi.1928922
AMA
1.Tosunoğlu Z, Şahin ÖF. Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings. Molecular Oncologic Imaging. 2026;6(2). doi:10.71286/moi.1928922
Chicago
Tosunoğlu, Zehranur, and Ömer Faruk Şahin. 2026. “Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET CT Findings”. Molecular Oncologic Imaging 6 (2). https://doi.org/10.71286/moi.1928922.
EndNote
Tosunoğlu Z, Şahin ÖF (July 1, 2026) Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings. Molecular Oncologic Imaging 6 2
IEEE
[1]Z. Tosunoğlu and Ö. F. Şahin, “Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings”, Molecular Oncologic Imaging, vol. 6, no. 2, July 2026, doi: 10.71286/moi.1928922.
ISNAD
Tosunoğlu, Zehranur - Şahin, Ömer Faruk. “Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET CT Findings”. Molecular Oncologic Imaging 6/2 (July 1, 2026). https://doi.org/10.71286/moi.1928922.
JAMA
1.Tosunoğlu Z, Şahin ÖF. Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings. Molecular Oncologic Imaging. 2026;6. doi:10.71286/moi.1928922.
MLA
Tosunoğlu, Zehranur, and Ömer Faruk Şahin. “Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET CT Findings”. Molecular Oncologic Imaging, vol. 6, no. 2, July 2026, doi:10.71286/moi.1928922.
Vancouver
1.Zehranur Tosunoğlu, Ömer Faruk Şahin. Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings. Molecular Oncologic Imaging. 2026 Jul. 1;6(2). doi:10.71286/moi.1928922