The Relationship Between Thyroid Diseases and Irisin Hormone

Abstract

Introduction: The aim of this study is to investigate the relationship between irisin, a new test with similar effects on energy metabolism and thermogenesis, and thyroid hormones. Material and Methods: 86 subjects included in the study. The subjects were divided into three groups as euthyroid, hypothyroid and hyperthyroid group by evaluating their TSH and fT4 levels. For all subjects, gender, age, medical history and blood test results were examined. Irisin levels of all groups were measured. Statistical analysis was performed with the obtained data. Results: A total of 86 people; 30 patients with newly diagnosed hypothyroidism, 28 patients with newly diagnosed hyperthyroidism and 28 euthyroid individuals as the control group were included in the study.The mean irisin level was highest in the hyperthyroid group and lowest in the hypothyroid group. The mean irisin level was found to be significantly higher in the hyperthyroid group than in the hypothyroid and control group (p˂0.01).The irisin level was found to be significantly higher in the control group than in the hypothyroid group (p˂0.01). A statistically significant negative correlation was found between the irisin levels and TSH levels (p˂0.01). A statistically significant positive correlation was found between the irisin levels and fT4,fT3 levels (p˂0.01). Conclusion: A significant correlation has been found between the TSH,fT3,fT4 and irisin.It was found that as TSH levels increase, irisin levels decreased and that as fT3, fT4 levels increase, irisin levels increased.We believe that irisin can be used as a new test in the follow-up and diagnosis of thyroid diseases, with studies with larger sample size and long-term follow-up in future.

Keywords

• Irisin hormone
• Hypothyroidism
• Hyperthyroidism
• Thyroid diseases
• Thyroid function test

Tiroid Hastalıkları ve İrisin Hormonu Arasındaki İlişki

Abstract

Amaç: Bu çalışmanın amacı, enerji metabolizması ve termogenez üzerine benzer etkileri bulunan, yeni bir test olan irisin ile tiroid hormonları arasındaki ilişkiyi araştırmaktır. Yöntem: 86 kişi çalışmaya dahil edildi. Çalışmaya alınanlar, TSH ve sT4 düzeyleri değerlendirilerek ötiroid, hipotiroidi ve hipertiroidi grubu olarak üç gruba ayrıldı. Tüm olgularda cinsiyet, yaş, tıbbi öykü ve kan testi sonuçları incelendi. Tüm grupların irisin seviyeleri ölçüldü. Elde edilen verilerle istatistiksel analiz yapıldı. Bulgular: Yeni tanı almış 30 hipotiroidi hastası, 28 hipertiroidi hastası ve kontrol grubu olarak 28 ötiroid birey olmak üzere toplam 86 kişi çalışmaya alındı. Ortalama irisin düzeyi hipertiroidi grubunda en yüksek, hipotiroidi grubunda en düşüktü. Ortalama irisin düzeyi hipertiroidi grubunda, hipotiroidi ve kontrol grubuna göre anlamlı olarak daha yüksek bulundu (p˂0.01).İrisin düzeyi, kontrol grubunda hipotiroidi grubuna göre anlamlı olarak daha yüksek bulundu (p˂0.01). İrisin düzeyleri ile TSH düzeyleri arasında istatistiksel olarak anlamlı negatif korelasyon bulundu (p˂0.01). İrisin seviyeleri ile fT4, fT3 seviyeleri arasında istatistiksel olarak anlamlı pozitif korelasyon bulundu (p˂0.01). Sonuç: TSH, fT3, fT4 ve irisin arasında anlamlı bir korelasyon bulunmuştur. TSH düzeyi arttıkça irisin düzeyinin düştüğü ve fT3, fT4 düzeyi arttıkça irisin düzeyinin arttığı saptanmıştır. İrisinin, gelecekte yapılacak daha kapsamlı ve uzun süreli takipli çalışmalarla tiroid hastalıklarının takibinde ve tanısında yeni bir test olarak kullanılabileceğini düşünmekteyiz.

Keywords

• İrisin hormonu
• Hipotiroidi
• Hipertiroidi
• Ötiroidi
• Tiroid hastalıkları
• Tiroid fonksiyon testi

Supporting Institution

yok

References

1. Sawin CT, Castelli WP, Hershman JM, McNamara P, Bacharach P. The aging thyroid: thyroid deficiency in the Framingham study. Arch Intern Med 1985;145: 1386-1388.
2. Kologlu S. Endokrinoloji Temel ve Klinik. Medical Network & Nobel. 1.Baskı: s. 139-158,1996
3. Ozata M. Tiroid Hastalıkları Tanı ve Tedavisi. Tiroid hormonları ve tiroid hastalıklarının fizyopatolojisi. Gata Basımevi:1-15, 2003.
4. Boström P , Wu J, Jedrychowski MP, Korde A, Ye, L Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti M, Vind BF, Hua T, Saverio C, Højlund K, Gygi SP, Spiegelman BM. A PCG1-alphadependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481: 463-468.
5. Korta P, Pocheć E, Mazur-Biały A. Irisin as a Multifunctional Protein: Implications for Health and Certain Diseases. Medicina (Kaunas). 2019;55(8):485. Published 2019 Aug 15. doi:10.3390/medicina55080485
6. Vihang A N , Michael D, Ruth T Y, Emi E, Yong-Xu W, Ester B, Maria M M, Michael C N, Yuhua Z, Henry J, Heonjoong K, Reuben J S, Ronald M E., AMPK, and PPAR delta agonists are exercise mimetics. Cell, 2008. 134(3): p. 405-415.
7. Guardiola-Diaz HM, Rehnmark S, Usuda N, Albrektsen T, Feltkamp D, Gustafsson JA, Alexson SE. Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization. Journal of Biological Chemistry, 1999. 274 (33): p. 23368-23377.
8. Park KH, Zaichenko L, Brinkoetter M, et al. Circulating irisin in relation to insulin resistance and the metabolic syndrome [published correction appears in J Clin Endocrinol Metab. 2014 May;99(5):1910]. J Clin Endocrinol Metab. 2013;98(12):4899-4907. doi:10.1210/jc.2013-2373

9. Iwen KA, Oelkrug R, Brabant G. Effects of thyroid hormones on thermogenesis and energy partitioning. J Mol Endocrinol. 2018 Apr;60(3):R157-R170. doi: 10.1530/JME-17-0319. Epub 2018 Feb 6. PMID: 29434028.
10. Wei J , Takahide M, Tomoko K, Takahiro S, Shin-Ichi N, Teiji T, Satoru S, Kiyoshi H. Expression of thyroid hormone receptor alpha in 3T3-L1 adipocytes; triiodothyronine increases the expression of lipogenic enzyme and triglyceride accumulation. J Endocrinol, 2004. 182(2): p. 295-302.
11. Viguerie N , Millet L, Avizou S, Vidal H, Larrouy D, Langin D, Regulation of human adipocyte gene expression by thyroid hormone. J Clin Endocrinol Metab, 2002. 87(2): p. 630-634.
12. Liu, J., Li J, Li WJ, Wang CM. The role of uncoupling proteins in diabetes mellitus. J Diabetes Res, 2013. 2013: p. 585-597.
13. Rousset, S., Alves-Guerra MA, Mozo J, Miroux B, Cassard-Doulcier AM, Bouillaud F, Ricquier D., The biology of mitochondrial uncoupling proteins. Diabetes, 2004. 53 Suppl 1: p. 130-135.
14. Lee, J.Y., Takahashi N, Yasubuchi M, Kim Y, Hashizaki H, Kim MJ, Sakamoto T, Goto T, Kawada T. Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes. Am J Physiol Cell Physiol, 2012. 302(2): p. 463-472.
15. Ugur K, Aydin S, Kuloglu T, et al. Comparison of irisin hormone expression between thyroid cancer tissues and oncocytic variant cells. Cancer Manag Res. 2019;11:2595-2603. Published 2019 Mar 28. doi:10.2147/CMAR.S201979
16. Ruchala M, Zybek A, Szczepanek-Parulska E. Serum irisin levels and thyroid function-newly discovered association. Peptides 2014; 60: 51-55
17. Ateş I, Altay M, Topcuoglu C, Yılmaz FM. Circulating levels of irisin are elevated in hypothyroidism, a case-control study. Arch Endocrinol Metab. 2016 Apr;60(2):95-100.