The Relationship Between Thyroid Diseases and Irisin Hormone

Öz

Introduction: The aim of this study is to investigate the relationship between irisin, a new test with similar effects on energy metabolism and thermogenesis, and thyroid hormones. Material and Methods: 86 subjects included in the study. The subjects were divided into three groups as euthyroid, hypothyroid and hyperthyroid group by evaluating their TSH and fT4 levels. For all subjects, gender, age, medical history and blood test results were examined. Irisin levels of all groups were measured. Statistical analysis was performed with the obtained data. Results: A total of 86 people; 30 patients with newly diagnosed hypothyroidism, 28 patients with newly diagnosed hyperthyroidism and 28 euthyroid individuals as the control group were included in the study.The mean irisin level was highest in the hyperthyroid group and lowest in the hypothyroid group. The mean irisin level was found to be significantly higher in the hyperthyroid group than in the hypothyroid and control group (p˂0.01).The irisin level was found to be significantly higher in the control group than in the hypothyroid group (p˂0.01). A statistically significant negative correlation was found between the irisin levels and TSH levels (p˂0.01). A statistically significant positive correlation was found between the irisin levels and fT4,fT3 levels (p˂0.01). Conclusion: A significant correlation has been found between the TSH,fT3,fT4 and irisin.It was found that as TSH levels increase, irisin levels decreased and that as fT3, fT4 levels increase, irisin levels increased.We believe that irisin can be used as a new test in the follow-up and diagnosis of thyroid diseases, with studies with larger sample size and long-term follow-up in future.

Anahtar Kelimeler

• Irisin hormone
• Hypothyroidism
• Hyperthyroidism
• Thyroid diseases
• Thyroid function test

Tiroid Hastalıkları ve İrisin Hormonu Arasındaki İlişki

Öz

Amaç: Bu çalışmanın amacı, enerji metabolizması ve termogenez üzerine benzer etkileri bulunan, yeni bir test olan irisin ile tiroid hormonları arasındaki ilişkiyi araştırmaktır. Yöntem: 86 kişi çalışmaya dahil edildi. Çalışmaya alınanlar, TSH ve sT4 düzeyleri değerlendirilerek ötiroid, hipotiroidi ve hipertiroidi grubu olarak üç gruba ayrıldı. Tüm olgularda cinsiyet, yaş, tıbbi öykü ve kan testi sonuçları incelendi. Tüm grupların irisin seviyeleri ölçüldü. Elde edilen verilerle istatistiksel analiz yapıldı. Bulgular: Yeni tanı almış 30 hipotiroidi hastası, 28 hipertiroidi hastası ve kontrol grubu olarak 28 ötiroid birey olmak üzere toplam 86 kişi çalışmaya alındı. Ortalama irisin düzeyi hipertiroidi grubunda en yüksek, hipotiroidi grubunda en düşüktü. Ortalama irisin düzeyi hipertiroidi grubunda, hipotiroidi ve kontrol grubuna göre anlamlı olarak daha yüksek bulundu (p˂0.01).İrisin düzeyi, kontrol grubunda hipotiroidi grubuna göre anlamlı olarak daha yüksek bulundu (p˂0.01). İrisin düzeyleri ile TSH düzeyleri arasında istatistiksel olarak anlamlı negatif korelasyon bulundu (p˂0.01). İrisin seviyeleri ile fT4, fT3 seviyeleri arasında istatistiksel olarak anlamlı pozitif korelasyon bulundu (p˂0.01). Sonuç: TSH, fT3, fT4 ve irisin arasında anlamlı bir korelasyon bulunmuştur. TSH düzeyi arttıkça irisin düzeyinin düştüğü ve fT3, fT4 düzeyi arttıkça irisin düzeyinin arttığı saptanmıştır. İrisinin, gelecekte yapılacak daha kapsamlı ve uzun süreli takipli çalışmalarla tiroid hastalıklarının takibinde ve tanısında yeni bir test olarak kullanılabileceğini düşünmekteyiz.

Anahtar Kelimeler

• İrisin hormonu
• Hipotiroidi
• Hipertiroidi
• Ötiroidi
• Tiroid hastalıkları
• Tiroid fonksiyon testi

Kaynakça

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