Dental Stem Cells

Abstract

Recently, tooth tissue engineering has attracted more and more attention. Teeth exhibit limited repair in response to damage, and dental pulp stem cells provide a source of cells to replace those damaged and to facilitate repair. Mesenchymal stem cells (MSCs) are multipotent stem cells which can be differentiated into a variety of cell types. The potential sources of MSCs for tooth regeneration mainly include stem cells from human exfoliated deciduous teeth (SHEDs), dental pulp stem cells (DPSCs), and stem cells from the apical part of the papilla (SCAPs), stem cells from the dental follicle (DFSCs), and periodontal ligament stem cells (PDLSCs). As dental stem cells share similar properties with mesenchymal stem cells, there is also considerable interest in their wider potential to treat disorders involving mesenchymal cell derivatives. This review outlines the recent progress in the dental stem cells used in tooth regeneration.

Keywords

• Regeneration,Repair,Stem Cell,Tooth

Her Yönüyle Dental Kök Hücreler

Abstract

Son zamanlarda, diş ile alakalı doku mühendisliği giderek daha fazla dikkat çekmektedir. Dişler hasara yanıt olarak sınırlı onarım sergiler ve dental pulpa kök hücreleri hasarlı olanların yerini almak ve onarımı kolaylaştırmak için bir hücre kaynağı sağlar. Mezenkimal kök hücreler (MSCs), çeşitli hücre tiplerine farklılaşabilen kök hücrelerdir. Diş rejenerasyonu için potansiyel MSCs kaynakları; insan dökülen süt dişleri kök hücreleri (SHEDs), dental pulpa kök hücreleri (DPSCs), apikal papilla kök hücreleri (SCAPs), diş folikülü kök hücreleri (DFSCs) ve periodontal ligament kök hücreleri (PDLSCs)’dir. Dental kök hücreler mezenkimal kök hücrelerle benzer özellikleri paylaştığından, mezenkimal kök hücre hastalıklarının tedavisi için büyük ilgi görmektedir. Bu derleme, diş rejenerasyonunda kullanılan dental kök hücrelerdeki son ilerlemeleri anlatmaktadır.

Keywords

• Diş,Kök Hücre,Rejenerasyon,Yenilenme

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