The Relationship between Hospital Mortality and Hematological Parameters in Acute Ischemic Stroke Patients

Abstract

In recent years there are many pieces of research about various haematologic parameters that were related to the prognosis of atherosclerosis and thromboembolic events. In our study we searched possible prognostic factors predicting hospital mortality in patients with acute ischemic stroke in neurology intensive care unit. We examined ninety-nine acute ischemic stroke patients which were followed in neurology intensive care unit, between January 01, 2019 and December 31, 2019. History, neurologic examination, computed tomography and diffusion weighted MRI of brain were applied for acute ischemic stroke diagnosis. Age, gender, ischemic lesions' localisation and hematologic parameters, (leukocyte, neutrophil, lymphocyte, monocyte, hemoglobin, platelet, mean platelet volume-MPV, red cell distribution width-RDW, neutrophil/lymphocyte ratio-NLO, platelet/lymphocyte ratio-PLO, lymphocyte / monocyte ratio-LMO) were compared to find possible prognostic factors which could be correlated with hospital mortality. In this study; age, gender, ischemic lesions indicated no difference for hospital mortality. In additional haematologic parameters indicated no significant difference except lymphocyte-to-monocyte ratio (LMR). Lymphocyte-to-monocyte ratio (LMR:2.06±1.46, p=0.011, sensitivity: 61.7%, specificity: 48.1%) was statistically lower in patients who died in the hospital. Based on the study results, lowe rlymphocyte-to-monocyte ratio (LMR) is a haematologic parameter for predicting hospital mortality for acute ischemic stroke patients. However, more detailed and prospective research should be carried out in this field.

Keywords

• Acute Ischemic Stroke,Hospital Mortality,Lymphocyte-Monocyte Ratio

Akut İskemik İnmeli Hastalarda Hastane Mortalitesi ile Hematolojik Parametrelerin İlişkisi

Abstract

Son yıllarda çeşitli hematolojik parametrelerin ateroskleroz ve tromboembolik olayların prognozu ile ilişkilendirildiği birçok çalışma mevcuttur. Biz bu çalışmada nöroloji yoğun bakım ünitesine akut iskemik inme tanısı ile yatırılan hastalarda, hastane mortalitesini ön görmeye katkı sağlayabilecek muhtemel prognostik faktörleri araştırdık. Bu çalışmaya 01.01.2019-31.12.2019 tarihleri arasında acil serviste akut iskemik inme tanısı aldıktan sonra nöroloji yoğun bakım ünitesine yatırılan 99 hasta dahil edildi. Akut iskemik inme tanısı için hastaların tıbbi öyküsü, nörolojik muayene bulguları, bilgisayarlı tomografi, difüzyon MR görüntüleri kullanıldı. Hastane mortalitesi ile ilişkili olabilecek olası prognostik faktörleri bulmak için yaş, cinsiyet, iskemik lezyonların lokalizasyonu ve hematolojik parametreler (lökosit, nötrofil, lenfosit, monosit, hemoglobin, platelet, mean platelet volume-MPV, red cell distrubition width-RDW, nötrofil/lenfosit oranı-NLO, platelet/lenfosit oranı-PLO, lenfosit/monosit oranı-LMO) karşılaştırıldı. Bu çalışmada; yaş, cinsiyet ve iskemik lezyonlar ile hastane mortalitesi arasında anlamlı farklılık saptanmadı. Ayrıca lenfosit-monosit oranı (LMO) dışındaki hematolojik parametrelerde de anlamlı bir farklılık saptanmadı. Lenfosit-monosit oranı (LMO:2.06±1.46, p=0.011, sensitivite: %61.7, spesifite: %48.1) hastanede eksitus olan hastalarda istatiksel anlamlı olarak daha düşük bulundu. Sonuç olarak, düşük lenfosit-monosit oranının erken dönem prognozu göstermede faydalı olabilecek bir hematolojik belirteç olduğu, ancak bu konuda daha kapsamlı ve prospektif çalışmaların gerektiği kanaatine varıldı.

Keywords

• Akut İskemik İnme,Hastane Mortalitesi,Lenfosit-Monosit Oranı

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